Endocrine Abstracts

Cushing’s syndrome is a condition characterized by hypercortisolism (endogenous and exogenous) regardless of its etiology. Hypercortisolism caused by an adrenocorticotropin secreting pituitary adenoma is defined as Cushing’s disease. These tumors represent 10-12% of all pituitary adenomas. ACTH-secreting macroadenomas occur in only 4-23% of all patients with Cushing’s disease. We present the case of 56-year-old female patient with hypercortisolism and stigmata o...

Soy isoflavone daidzein exerts some beneficial effects in different ageing-related, chronic diseases and may represent a promising alternative to classical estrogenization of the prostate cancer suffering subjects. The aim of this study was to examine the effects of daidzein on the adrenocortical vascular network and hormonal output in a rat model of the mild andropause. Adult (3 months old) Wistar rats were divided into sham-operated (SO; n=7), orchi...

Introduction: Acromegaly is a chronic disease that occurs as a result of excessive growth hormone secretion, caused by somatotropin-secreting tumors of the pituitary gland in 98% of cases. The first line of treatment for these patients is operative via transsphenoidal approach, however, absolute remission is not achieved in 50% of patients and pharmacological therapy is indicated.Case report: We will present the case of a 43-year-old patient who was hosp...

Objective: A great number of patients are self-referred to endocrinologist. Most of these patients had some research of their symptoms and have a specific diagnosis that they want to investigate.Methods: A retrospective chart review of 628 new consults conducted in one outpatient endocrine office at University of California, Los Angeles was conducted.Results: Of the 628 new patients 326 were referred by another physician and were e...

Background: Moderate hypophosphatemia is not an uncommon finding. As usually requiring no specific intervention, it might be neglected and serum phosphate measurements are sometimes skipped. Only 1% of phosphorus is in extracellular fluid so it is not a reliable marker of body phosphorus reserve and refractory chronic hypophosphatemia might be a sign of severe phosphorus depletion.Case presentation: A fifty-two-year-old male patient presented with a 12-m...

Introduction: CAH is among the most common inherited metabolic disturbances, caused by Ar mutations of genes that encode enzymes involved in the adrenal steroids synthesis. Male hypogonadism and CKD can complicate the course of CAH. Additionally, HD can influence the CAH management by unpredictable effects of ultrafiltration on the levels of administered drugs. The aim of our study is to demonstrate the influence of HD on LH/T levels of eugonadal male as well hypogonadal male ...

Graves’ disease (GD) is an autoimmune disease that can affect other tissues in addition to the thyroid gland. Depending on the intensity of the immune response, in addition to hyperthyroidism, orbitopathy, dermatopathy and acropachy can also occur. Extrathyroidal manifestations of GD are most often the result of a more pronounced immune response. Thyroid dermatopathy (TD) is a rare extrathyroidal manifestation of GD, almost always associated with Graves’ orbitopathy ...

Previous studies suggest that individuals characterized by high trait hostility may be more sensitive to stress and that this may contribute to their greater vulnerability to alcohol abuse. To characterize the stress reactivity of hostile individuals and to evaluate the possibility that serotonergic dysfunction may underlie their susceptibility to stress, we examined the effects of acute dietary tryptophan enhancement and stress on mood and physiological reactivity in low (LoH...

Serum calcitonin (CT) screening of thyroid nodules is a highly sensitive test for early diagnosis of medullary thyroid carcinoma (MTC) and is used for initial diagnosis and post-surgical follow-up. MTC is neuroendocrine tumor derived from parafollicular C cells which produce calcitonin. It is a rare tumor, accounting for 5-10% of all thyroid carcinomas, with a favorable prognosis if diagnosed early. A 74-year-old patient was referred to our clinic due to elevated basal CT leve...

Background: Thyroid hormones have regulatory effect on serotonin and noradrenaline and thyroid dysfunction is closely linked to some mental disorders. Besides depression and anxiety, and increased risk for suicide is demonstrated in patients with Graves’ disease (GD).The aim: of our research was to determine the symptomatology of depression in patients with hyperthyroidism and Graves’ orbitopathy (GO) and compare it with hyperthyroid patients w...