Endocrine Abstracts

The aim of this study was to assess thyroid homeostasis in patients with liver cirrhosis (LC) of non-viral etiology and analyze the association between serum thyroid parameters and A/C polymorphism in the deiodinase type 1 (DIO1) gene in these patients.Material and Methods: The study was conducted on 70 subjects: 50 patients with (LC) and 20 healthy controls. The thyroid homeostasis was evaluated by using «thyroid function tests», measurement o...

Muscle symptoms are the most common side effects of statin therapy and reasons for its discontinuation. Low serum vitamin D may contribute to statin-associated muscle symptoms (SAMS). The aim was to investigate the relationship between occurrence of SAMS and level of vitamin D (D), determine predictors of SAMS.Methods: 84 statin-treated patients were included in the study: 41 with SAMS (intolerant to ≥2 statins) and 43 patients without SAMS. We use...

Obesity is independently associated with poor control of blood pressure (BP) and weight reduction is generally recommended as the first line of treatment. However, the challenge remains to find the appropriate approach for weight reduction to influence BP status. The aim was to investigate the effect of non-pharmacologically and pharmacologically (metformin) induced weight loss on BP in obese hypertensive patients (HP). Methods: 100 HP (mean body mass in...

BackgroundVitamin D deficiency is a global health problem. Nowadays is intensively studied the influence of vitamin D on the course of autoimmune diseases of the thyroid gland.ObjectiveTo study the relationship between vitamin D status and metabolic parameters in premenopausal women with autoimmune hypothyroidism.Methods146 premenopausal women with autoimmune hypo...

Introduction: One of the objectives of weight loss in obesity is to prevent metabolic disorders. An important component in the maintenance of the achieved results is a change of eating behavior.Goal: To study the effect of liraglutide 3.0 mg on the dynamics of metabolic parameters and eating behavior in patients with obesity.Materials and methods: The study enrolled 42 obese patients in whom anthropometric parameters, metabolic par...

Introduction: Liraglutide 3.0 mg could be effective option for obesity management. It is known that patients who have ≥5% weight loss in 16 weeks (‘early responders’ (ERs)) will have ≥10% weight loss in 56 weeks [1]. Predictors of this early response (ER) in 16 weeks are unknown.Methods: 22 obese patients (30% men; median age 40.0 [33.0; 48.5]) were recruited. The exclusion criteria were diabetes, psychotic disorders, obesity due ...

Aim: Study the correlation between leptin and renal malfunction in patients with primary hypothyroidism (PH).Methods: 161 patients suffering from PH took part in the investigation. Criteria of choice were as follows: patients’ age from 36 to 60 and presence of PH. Presence of any acute or chronic renal disease or ischemic heart disease was the criteria of exclusion. The diagnosis was made on the basis of complaints, family history, typical clinical...

AimStudy the efficacy of empagliflozin effects on main cardiovascular risk factors in non-insulin-dependent diabetic patients with normal and excessive body weight.Objectives60 patients with type 2 diabetes who have been taking metformin for at least 6 months but haven’t reached the target level of glycated haemoglobin (HbA1c), as well as 10 healthy individuals were examined. Depending on the prescribed ...

The purpose of the work: to compare the changes in the global longitudinal strain of the left ventricle in obese patients with and without COPD.Material and methods of research: group I consisted of obese patients without COPD (n=50; 21 - males, mean age - 48.8±9.1 years). Group II – 40 patients with obesity and COPD, comparable in age, gender. Group III – 37 patients with COPD without obesity, comparable in age, gender and risk g...

The objective is to assess the presence of possible correlation between the calculated body fat percentage (BFP) indicator and indicators of metabolic control in women of reproductive age with polycystic ovarian syndrome (PCOS).Materials and Methods: The study included 80 women with a diagnosed PCOS according to the Rotterdam criteria. All study participants underwent standard general clinical studies with the determination of body mass index (BMI), wais...