Endocrine Abstracts

Introduction: The malignancy of the thyroglossal duct cyst is infrequent, 0.7 to 1% of the thyroglossal duct cysts, predominantly in women and euthyroid subjects, some associated with Hashimoto’s Thyroiditis. Clinical case: Male, 42 years old, with a 5-year history of a large anterior cervical tumor, diagnosed with Graves’ disease and thyroid orbitopathy. Cervical ultrasound reports right submandibular region mixed tumor mass 36 x30. mm with no...

The USMBDPCP is unique that it is the first study to consider the whole US- Mexico Border as one epidemiological unit. The project goal is to reduce the burden of diabetes among persons with type 2 diabetes living in the U.S.-Mexico border region. I Development of a Prevalence Study and identification of risk factors. II Implementation an intervention pilot study for diabetes prevention and control.Phase IThe diabetes prevalence su...

Identifying effective strategies and underneath molecular signatures is crucial to combat certain metabolic diseases with increasing incidence such as obesity and MASLD (metabolic dysfunction-associated steatotic liver disease). The hepatic secretome plays a crucial role at controlling global energy metabolism and inflammation in MASLD. However, the interplay between diet composition and the eating architecture on the dynamic response of secretome as a tool to improve disease ...

Adipose tissue is a highly active metabolic organ which, together with its role as an energy storage depot, produces a wide variety of bioactive molecules (i.e. adipokines) with important roles in the regulation of energy metabolism and homeostasis, immunity and inflammation. Alterations in lipid metabolism and/or in adipokine production associated to the excess of adipose tissue that defines obesity or to adipose tissue deficiency, as occurs in lipodystrophy, are linked to in...

Several Rab proteins control secretory granule trafficking and, hence, hormone release, by regulating the activity of different components of the secretory granule transport machinery. Particularly, Rab18 inhibits secretory granule movement, which leads to reduced neuropeptide and hormone secretion in PC12 pheochromocytoma cells and ACTH-secreting ATt20 cells, respectively, but how this GTPase accomplishes its role and the identity of the proteins that regulate Rab18 activity ...

Spanish Scientific Societies involved in diabetic patient care produced a consensus document with recommendations and quality indicators for hospital discharge reports (HDR).Objective: To analyse adequacy of HDR in diabetic patients from an Internal Medicine Service according to these recommendations (Med Clin (Bar) 2012 138 666.e1–666.e10).Methods: Study based on a programme continuity of care among ...

Psoriasis (PS) is a skin disease of immune T-cell mediated. It is well known that obesity is a risk factor for severity PS and PS is associated with the degree of overweight. In addition, patients with PS have increased risk of metabolic disorders such as diabetes mellitus (DM) and dyslipidaemia. All these processes are characterised by the presence of systemic chronic inflammation. Liraglutide, an agonist receptor GLP-1, is being used in the treatment of obesity and diabetes ...

Objective: 6% of people with diabetes present with diabetic foot as a complication, which means greater morbidity and mortality compared to those who do not. Its diagnosis and management by multidisciplinary teams including surgeons can improve these patients’ care. The objective was to analyze the main characteristics of patients and health results obtained, as well as to evaluate the impact of PAD (peripheral artery disease) existence in patients cared for in our multid...

Objectives: To determine the habits and lifestyle of the morbidly obese before and after bariatric surgery.Material and methods: Transversal study of two groups of morbidly obese patients attending the Endocrinology Unit of Puerta del Mar, Cádiz: one group before and the other after bariatric surgery. Clinical and analytical data of the patients was collected: socio-demographic and lifestyle characteristics, Bulit-R Questionnaire (Bulimia), BIS (imp...

Introduction: Hereditary phaeochromocytoma (PCC) and paraganglioma (PGL) account for 30–35% of cases and have some clinically relevant peculiarities.Material and methods: Retrospective, unicentric cohort study that included all genotyped patients (n=36, 27 with PCC and 9 with PGL) diagnosed at Hospital Clínico San Carlos (Madrid) between 1984 and 2013; 33% were germline mutation carriers (25% pseudohypoxic [PH] phenotype, 75% MAP-kinas...