Endocrine Abstracts

Introduction: The limit of quantification (LOQ) is defined as the lowest analyte concentration that can be reproducibly measured with defined imprecision expressed as CV (coefficient of variation). Low concentrations of hormones estradiol, LH, FSH and testosterone are essential in diagnosis and monitoring of various endocrine disorders. Automated immunoassays have well known advantages, but still limited in achieving necessary analytical sensitivity. The major concern is to pr...

Introduction: Biological variation (BV) data describe the variability of clinically important measurands around homeostatic set points within subjects (CVI) and between subjects (CVG). The availability of well characterized data enables the interpretation of laboratory results in clinical settings and can also be used to define analytical performance specifications. The aim of this study was to deliver BV estimates for anti-Müllerian hormone (AMH) and androstenedione amon...

Adrenal incidentalomas (AIs) are tumours accidentally detected by various imaging methods applied without suspecting adrenal pathology, indicating that most of them are nonfunctional. The most frequent hormonal alteration in AIs is autonomous cortisol secretion (ACS), a condition of altered hypothalamic-pituitary-adrenal axis activity, established on the biochemical parameters of hypercortisolism, without phenotype expression of Cushing’s syndrome. Since mild hypercortiso...

Impaired growth hormone (GH) secretion occurs in patients with Cushing’s disease (CD) as a result of cortisol excess. After a surgical treatment, eventually accompanied with radiation therapy, recovery of GH secretion is seen in only variable proportion of patients. According to some studies, it is recommended to perform assessment of GH secretion one to two years after surgical cure of CD. We report a case of a 40-years-old male admitted to the hospital because of sudden...

Sheehan syndrome (SS) caused by postpartum hemorrhage leads to varying degrees of pituitary insufficiency. With improved obstetrical care, ischemic pituitary necrosis is less common and, as a consequence, most cases of SS are being overlooked and diagnosis is delayed for years due to its nonspecific signs and symptoms. Data regarding the relationship between hypopituitarism and increased risk of venous thrombosis are inconsistent and need to be elucidated further. A 41-years-o...

The incidence of well differentiated thyroid carcinoma (TC), mostly papillary, is higher among patients with primary hyperparathyroidism (PHPT) compared to the general population, despite the similar frequency of thyroid nodules. The link between TC and Hashimoto thyroiditis (HT) is attributed to chronic inflammation, but the molecular association is poorly undestood. Herein, we explore the possible interplay between HT, PHPT and papillary TC through a case report and a litera...

Background: Functional studies demonstrate that Armadillo repeat-containing 5 (ARMC5) gene, controls apoptosis and steroid synthesis. A germline mutations in ARMC5 are recently been associated with Cushing syndrome and possibly can be responsible for a broader tumor predisposition.Case presentation: A 51-year-old woman presented with intermittent rectal bleeding. A colonoscopy revealed multiple colonic polyps, histopathological analysis showed tubular ad...

Cushing’s disease (CD) is a rare disorder caused by an increased secretion of adrenocorticotropin hormone (ACTH) from the anterior pituitary gland, usually as a result of pituitary adenoma. Transsphenoidal tumour resection is the best first line therapy option for these patients but 10–30% of them fail to achieve remission and need further treatment modalities to eliminate hypercortisolemia. Long-term outcomes and possible impacts on quality of life in these patients...

Introduction: Polyglandular autoimmune syndrome type II (PGA-II) is the most common immunoendocrinopathy syndrome, characterized by the obligatory occurrence of Addison disease in combination with thyroid autoimmune diseases and/or type 1 diabetes mellitus. This case report presents coexistence of mosaic Turner syndrome and pituitary micoradenoma in patient with PGA-II.Case report: A 30-year-old women underwent IVF for four times, with no success (always...

Autoimmune polyglandular syndromes (APS) are a rare group of autoimmune disorders that affect more than one endocrine gland, although non-endocrine organs can be involved. Concerning the variable evolution of this clinical entity over time, our case aims to emphasise the importance of regular follow-up and screening for polyglandular autoimmunity in selected patients in order to decrease a possibility of future complications consistent with APS. We report the case of a 20-year...