Endocrine Abstracts

Introduction: A rare cause of hyperparathyroidism in pediatric is parathyroid carcinoma. The variety of clinical manifestations of hyperparathyroidism and the associated hypercalcemia slows down the verification of its primary nature. Material and methods: Medical records of an inpatient 13y.o child.Results: Child from 5 pregnancies, 1 delivery. Pregnancy was accompanied by endemic goiter. Delivery at 39-40weeks, physiological. Pre...

Target: To study the incidence of postoperative complications in patients with transsphenoidal pituitary adenoectomy.Materials and research methods: 180 cases of PA subjected to TРА for the period from 2018 to 2020 were analyzed. Of these, 102 (56.6) women, 78 (43.3) men, patients were divided into two alternative groups: the first group - 93 (51.6%) patients with macroadenomas - 42 (45.2%) men, women 51 (54.8%), the second (comparison group) - 8...

Target.: To study the incidence of postoperative complications in patients with transsphenoidal pituitary adenoectomy.Materials and research methods: 180 cases of PA subjected to TРА for the period from 2018 to 2020 were analyzed. Of these, 102 (56.6) women, 78 (43.3) men, patients were divided into two alternative groups: the first group - 93 (51.6%) patients with macroadenomas - 42 (45.2%) men, women 51 (54.8%), the second (comparison group) - ...

Introduction: Neurodegeneration is one of the most common condition accompanied Diabetes Mellitus, Parkinson’s and Alzheimer’s diseases. Although its mechanisms intensively studied for many years, some questions of pathogenesis remain unclear. The aim of the study was investigate the effects of thyroid hormones and some neurotransmitters on the cerebral cortex of rats with experimental neurodegeneration. Materials and methods: Series of experim...

Three phenotypes of prediabetes are known: impaired fasting glucose (IFG), Impaired glucose tolerance (IGT), and combined IFG/IGT. IFG is associated with impaired early phase and normal second-phase of insulin secretion. IGT is associated with both impaired early and late phase of insulin secretion. Numerous studies have demonstrated efficacy of lifestyle intervention in improving 2-hr oral glucose tolerance and fasting plasma glucose (FPG) in individuals with prediabetes, whi...

Introduction: Ongoing scientific research indicates that there is a dangerous link between eating foods that contain gluten and Hashimoto’s thyroiditis (HT). Gluten can be an irritant to HT by creating inflammation in the thyroid gland. Selenium, an important oligoelement, is a component of the antioxidant system. Over the last decade, it has been ever more frequently discussed in the context of thyroid disorders. The purpose of this study was to highlight the positive r...

Physiological role of nerve growth factor (NGF) was characterized for the sensory and vegetative nervous systems, as well as for the central, endocrine and immune systems. The growth simulator and a cytokine, NGF is known to be involved in the metabolism of various pathological conditions. Recent clinical and academic studies among patients with diabetes mellitus, insulin resistance and Alzheimer’s disease have brought to light previously unreported cell and pathological ...

X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder of peroxisomal metabolism, characterized by deficient beta-oxidation of saturated very long chain fatty acids (VLCFA). The accumulation of VLCFAs is associated with demyelination of the nervous system, and impairment of steroid hormone synthesis in the adrenal cortex and the testis. The range of phenotypic expression is wide and dynamic. The three presentations most commonly seen are the childhood cerebral forms, a...

Background: Obesity represents a cardiovascular risk factor. Monocyte chemoattractant protein-1 (MCP-1) is a known regulator of monocyte recruitment to sites of inflammation, and participates at the early phases of atherogenesis. Apolipoproteins, as part of the lipoprotein particles, are classically coupled with cardiovascular risk distinction.Aims: To assess the association of anthropometric parameters, insulin resistance and MCP-1 levels with classic l...

Objective: To investigate the management of dermatological manifestations associated with PCOS and its management across Europe.Methods: This multinational retrospective study was conducted from June 2023 to January 2024. All women over 18 years of age attending a first consultation for PCOS from 1st January 2020 to 30th December 2023 in the UK (n=359), Turkey (n=239), Greece (n=92) and Georgia (n=10) were included. Th...