Endocrine Abstracts

Introduction: We aimed to investigate the homeostasis model assessment of insulin resistance (HOMA-IR) and relation of HOMA-IR with age, sex and body mass index (BMI) and the prevalence of diabetes in Turkish population of different regions.Methods: Cross-sectional observational study was done in the frame of Turkish prevalence of insulin resistance multicenter study. The study sample consisted of volunteers from seven different regions of Turkey. Weight...

Introduction: The relationship between hyperthyroidism and voice disorders has not been identified before. The aim of this study was to investigate the changes in the acoustic values in patients with subclinical thyrotoxicosis.Methods: In this study, acoustic voice analysis was evaluated in a total of 115 cases. Sixty of 115 individuals (18 men and 42 women) had subclinical thyrotoxicosis, aged between 18 and 65 years, and all had no history of laryngeal...

Pitüitary ACTH deficiency is one cause of secondary adrenal insufficiency. Genetic factors, autoimmunity, infiltrative disease, cranial trauma can cause ACTH deficiency. Hyperpigmented skin lesions are expected in primary adrenal insufficiency while they are very rare in secondary adrenal insufficiency. Striae are characterized by linear smooth bands of atrophic appearing skin. They are mostly associated with obesity, pregnancy, hypercortisolism/Cushing syndrome. Striae a...

Introduction: Primary hyperparathyroidism (PHPT) clinic occurs when the parathyroid glands secrete excess parathormone (PTH) due to hyperplasia, adenomatous or carcinomatous change. In the pathogenesis of the disease, dysregulation has been observed in extracellular signal-regulated 1/2 (ERK 1/2) pathways from the mitogen activated protein kinase (MAPK) family, c-Jun N-terminal kinase (JNK) pathways, and phosphatidylinositol-3 kinase (PI3K) pathways. Progranulin (PGRN) is a gl...

Introduction: Isotretinoin (Iso) treatment in acne disease may cause dyslipidemia and increased liver enzymes. Its effects on lipid and glucose metabolism may cause atherogenic complications. The aim of this study was to evaluate carotis intima–media thickness (CIMT), HOMA-IR, and osteopontin (OPN) levels in acne patients on Iso treatment.Methods: Iso treatment given 21 patients are included in this study. They followed for 4 months. 21 patients wit...

Background: Thyroid nodules diagnosed as Bethesda category IV (follicular neoplasm/suspicious for follicular neoplasm (FN/SFN)) are recommended for surgery. However, only 25% of these nodules turn to be malignant on histopathology. Therefore, selection of nodules for surgery diagnosed as Bethesda category IV is important. We aimed at to define the predictive factors for malignancy and predictive risk indices for selection of surgery.Method: The records o...

ObjectiveThis was a systematic review with meta-analysis aiming to identify if patients with Klinefelter syndrome (KS) had a reduced full scale intelligent quotient (IQ) when compared to controls. Reduced IQ is shown to have a negative multifaceted effect on individuals’ Quality of Life (QoL), having been shown as a predictor of future success, increased criminal behaviour, post-traumatic stress disorder (PTSD), lower academic achievements and i...

Introduction: Primary hyperparathyroidism (pHPT) is the third most frequently seen endocrine disease with autonomous overproduction of parathyroid hormone (PTH) in one or more parathyroid glands. It’s associated with osteoporosis, bone fractures, nephrolithiasis, renal failure and increased cardiovascular risk. We aimed to investigate the distribution of the clinical manifestations and biochemical features in patients with pHPT.Methods: A retrospect...

Aims: Impact of gestational diabetes mellitus on the coagulation system, dynamics involved at a pathophysiological level and the exact mechanism remain unclear.To evaluate association between diabetes-related parameters and haemostatic factors in order to search for a tendency of thrombosis in gestational diabetes mellitus.Methods and Material: Nineteen pregnant women who had gestational diabetes mellitus, 16 healthy pregnant and 1...

Introduction: Thyroid ophthalmopathy occurs generally due to Graves’ disease. Only a few cases were reported about ophthalmopathy in the years following a thyroidectomy and RAI therapy or metastatic papillary thyroid cancer.Case: A forty-six-year-old female patient was operated on for the fine needle aspiration biopsy (FNAB) result of a suspicious follicular neoplasia. A pathology examination showed a papillary microcarcinoma and Hashimoto thyroidit...