Endocrine Abstracts

Introduction: Primary hyperparathyroidism is associated with cardiovascular disease. In addition, data about cardiovascular abnormalities in patients with asymptomatic primary hyperparathyroidsm (APHPT) is’nt clear. In this study, we aimed to examine the cardiac structure–functions and hs-CRP levels in patients with APHPT.Materials and method: Thirty-one patients with APHPT and 32 sex- and age-matched control cases with similar cardiac risk fac...

Thyroid lymphomas are very rare diseases of the thyroid.We present three patients with thyroid lymphoma administered our department last year. Two of the patients presented with rapidly enlarging neck mass with pressure symptoms, and the other was diagnosed during the evaluation of a thyroid nodule. Two patients had the Hashimoto’s thyroiditis diagnosis. All the patients underwent surgery, since no exact diagnosis could be established with fine feed...

Non-hodgkin lymphoma (NHL) is a hematological tumor caused by abnormal lymphoid proliferation. NHL can arise in any part of the body, including central nervous system (CNS). However, hypothalamus involvement is a rare presentation. Here, we report a case of hypothalamic infiltration of NHL Diffuse Large B-cell lymphoma (DLBCL) in a 21 years old male patient with panhypopituitarism and diabetes insipidus. The patient was admitted to the hospital with a history of nausea, vomiti...

ApoB isoforms are components of the chylomicron, and of the atherogenic LDL and Lp(a) particles. Ex26 is exceptionally long at 7.57kb as most exons are <500bp. Ex26 is also the site of RNA editing, which generates the ApoB48 isoform instead of ApoB100. The first 3kb of ex26 contains 15 sequences matching the splice site consensus, which could be used in splicing, but are not. Splice sites matching the consensus but which are not used are called pseudosites. How the spliceos...

Background: There is some evidence suggesting an interaction between renin-angiotensin-aldosterone system and parathyroid hormone (PTH). Decreased aldosterone levels after parathyroidectomy have been reported in patients with primary hyperparathyroidism (PHPT). Recently, most of the diagnosed patients with PHPT are mild or asymptomatic. Our aim was to investigate plasma aldosterone and renin concentrations in patients with asymptomatic PHPT.Methods: Thir...

Background: Mutations in succinate dehydrogense-B (SDH-B) or von Hippel Lindau (VHL) genes can result in chromaffin tumours.Objective: To compare the clinical phenotypes of subjects developing chromaffin tumours as a result of SDH-B or VHL mutations.Subjects: Thirty-one subjects with chromaffin tumours. Sixteen subjects had SDH-B gene mutations and 15 subjects had a diagnosis of VHL.<p ...

B-type natriuretic peptide (BNP) is a hormone secreted from the heart in response to volume load and serves clinically as a reliable biomarker in the diagnosis of cardiac dysfunction and heart failure. As patients with heart failure present an increased risk for developing diabetes, we aimed to investigate the role of BNP on parameters of glucose metabolism in a placebo-controlled crossover study performed in 10 healthy volunteers (25±1 years; BMI 23±1 kg/m2</su...

Mitogenic signaling by receptor tyrosine kinases that involve increased activity of phosphatidylinositol-3-kinase (PI3K) and over-activation of protein kinase B (PKB/Akt) triggers a cascade of responses that drive tumour progression in a variety of human cancers. Some of these events have been associated with diminished expression of the cell cycle inhibitor p27 through inhibition of a Forkhead transcription factor (FKHR-L1) by Akt, while some others have recently been reporte...

We have investigated the effects of estradiol valerat plus dienogest and raloxifene on serum high sensitive C - reactive protein (hsCRP) levels in healthy postmenopausal women. This study was approved by the local ethics committee. Forty eight healthy postmenopausal women were randomly divided into three groups. While group I (n=16) was given 60 mg raloxifene, group II (n=16) received continuously 2 mg estradiol valerat plus 2 mg dienogest. Group III (n=16) received no medicat...

Dipeptidyl peptidase 4 (DPP-4) is thought to play a role in the pathophysiology of metabolic and inflammatory diseases. Increased ADA activity has been suggested to induce insulin resistance and inflammation. We investigated DPP-4 and ADA activities, serum nitric oxide (NO) level and nitric oxide synthase (NOS) activity which are the oxidative stress parameters in patients with PCOS. Fifty two women with PCOS and 41 healthy women were included in this study. Serum ADA activity...