Endocrine Abstracts

Women with COVID-19 and Long COVID (symptoms >4 weeks) have reported AUB. We investigated (i) the association between COVID-19/Long COVID and AUB and (ii) ovarian sex hormones across the menstrual cycle in women with Long COVID. Two studies were completed with ethical approvals and consent. Firstly, a retrospective online survey ‘The Covid-19 Pandemic and Women’s Reproductive Health’ was conducted March-May 2021 with UK participants >18 years old (n<...

Introduction: The aim of the study was to assess antropometric and metabolic parametres in women with previous gestational diabetes mellitus (GDM) during a 30-month observation.Design: Our prospective study cohort consisted of 367 women with GDM diagnosed according to WHO criteria. Oral glucose tolerance test (OGTT) was performed during 6-10 weeks and 12, 18, 24, 30 months after delivery. On every 6th month between 12th and 30th month after delivery we e...

Introduction: Acromegaly is a rare disorder caused by excessive growth hormone production. Common clinical manifestations are visual changes as well as serious systemic complications. In childhood and adolescence, excessive growth hormone production leads to abnormal tall stature. To date, only a few studies have been published focusing on analysing the growth of patients with acromegaly, in particular regarding the growth of their parents and siblings. A&#...

Graves disease (GD) is autoimmunological disorder leading most often to hyperthyroidism and invasive-edema opthalmopathy (Graves opthalmopathy – GO).Aim: Estimation of the relation of visual evoked potentials (VEP) results with the indicators of activity and advancement of the progress of GO.Materials and methods: The examined group consisted of 45 patients between the age of 24 and 77, hospitalized in the Department of Endocr...

Background: There is growing evidence that adhesion molecules, proinflammatory cells and cytokines play an important role in a variety of cardiac pathophysiological conditions; Cytokines are responsible for the modulation of immune and inflammatory processes. It has been suggested that cytokines such as IL-1, IL-2, IL-6, IL-10 and TNF alpha are important modulators of atherosclerotic effects with IL-2 and Interferon γ having a proinflammatory atherogenic effect and IL-8 a...

Background: Clinically severe or recurrent subacute thyroiditis (SAT) frequently requires treatment with high cumulative doses of systemic steroids. Such therapy is associated with high risk of steroid-related complications. The DLISAT study aims to evaluate the efficacy and safety of intrathyroidal dexamethasone and lidocaine injections (DLI) in specific patient cohorts compared to standard oral steroid therapy. This report presents preliminary results after the initial six m...

Introduction: Interferon alpha (IFN alpha) is a cytokine with pleiotropic effects and via different pathways influences secretion of certain cytokines and hormones. Growth Hormone (GH) secreted from the pituitary has its physiological effects on various target tissues. The question is how IFN alpha administered in various type of diseases influences GH secretion. This study investigated acute effect of IFN-alpha on GH mRNA expression in rat anterior pituitary<p class="abst...

Introduction: Saliva is an interesting alternative to blood in clinical evaluation of endocrine function. Certain advantages of saliva collection must be considered, when comparing with conventional blood sampling. Vital arguments are that procedure is easy, non-invasive and stress-free. The studies on correlation between salivary and serum thyroid hormones are scarce and contradictory. The goal of our research was to assess if salivary thyroid hormone levels reflect serum con...

Background: Collagen, whose biosynthesis is regulated by thyroid hormones, is the most abundant connective tissue protein. Ehlers–Danlos syndrome alters collagen structure, which may affect bone mineral density (BMD). The purpose of this study was to assess the effect of autoimmune thyroiditis on BMD in females with Ehlers–Danlos syndrome.Material and methods: The study involved a prospective assessment of 30 female patients, aged 20–53 ye...

Background: Ehlers–Danlos syndrome is a group of genetic diseases characterized by alterations in connective tissue structure, which may lead to increased bone mass loss and predispose to osteopenia and osteoporosis. The effect of obesity on bone mass loss is inconclusive. The purpose of this study was to assess the relationship between obesity and bone mineral density (BMD) in women with Ehlers–Danlos syndrome.Material and methods: The study i...