Searchable abstracts of presentations at key conferences in endocrinology

ea0086p266 | Reproductive Endocrinology | SFEBES2022

Identification of a transcription factor that modulates ERα-Dependent Hypothalamic Estrogen Sensing

Fernandes-Freitas Isabel , Milona Alexandra , Ramos-Pittol Jose , Manchishi Stephen , Rainbow Kara , Lam Brian , Tadross John , Beucher Anthony , Colledge William , Cebola Ines , Murphy Kevin , Miguel-Aliaga Irene , Yeo Giles , Dhillo Waljit , Owen Bryn

Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It is thought to require estrogen to have simultaneous positive and negative feedback effects on two spatially-distinct regions of the hypothalamus, the arcuate nucleus and ‘AVPV’ nucleus. However, the mechanistic basis for this differential effect is not known. Therefore, we mapped the genomic binding of the estrogen receptor alpha (ERα) in bot...

ea0090p181 | Reproductive and Developmental Endocrinology | ECE2023

In Vitro Fertilization in Polycystic Ovary Syndrome: Treatment Individualization Based on Genetic Singularities

Carreira Ana , Vieira Ines , Reis Sandra , Carvalho Alexandra , Dias Conceicao , Fernandes Silvana , Ferreira Ana , Rodrigues Dircea , Sousa Ana , Ramalho-Santos Joao , Cortesao Paulo , Almeida-Santos Teresa , Ramalhinho Ana , Moura-Ramos Mariana , Melo Miguel , Paiva Isabel

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory infertility. Polymorphisms in genes related to follicular recruitment and development, such as the follicle-stimulating hormone receptor (FSHR) and the oestrogen receptor 1 (ESR1) genes, and their impact on biochemical phenotype and response to controlled ovarian stimulation in women with PCOS have been studied in different populations, with inconsistent results.<p class="abstext...

ea0090ep437 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Real-world effectiveness analysis of oral versus subcutaneous semaglutide in patients with type 2 diabetes mellitus

Ferrer Garcia Juan Carlos , Albalat-Galera Raquel , Moya Victor Atienza , Hernandez Jessica Sanchez , Palomar Luis Arribas , Casamayor Ignacio Ramos , Fullana Ana Artero , Blanco Cintia Gonzalez , Portilla Ana Jimenez , Juan Carlos Sanchez

Background and Objective: Semaglutide, a glucagon-like peptide 1 (GLP1a) receptor agonist, reduces the risk of major adverse cardiovascular events in patients with type 2 diabetes mellitus (DM2). An oral version of semaglutide is now available, and patients may prefer it to the subcutaneous form. Our objective was to compare the effectiveness and safety of both formulations in real life.Methods: Retrospective real-world efficacy analysis including aGLP1-...

ea0090ep683 | Pituitary and Neuroendocrinology | ECE2023

Evaluation of the ACTH-CLU index for the differential diagnosis of ACTH-dependent Cushing’s syndrome

Izquierdo Belen Garcia , Rodriguez Delgado Laura , Araujo Castro Marta , Abad Lopez Ainhoa , Garcia Gomez Carlos , Rubio Ramos Miguel , Guzman Sanz Jorge , Diez Fernandez Natalia , Capristan Diaz Vanessa , Palacios Nuria

Introduction: Differentiation between Cushing’s disease (CD) and ectopic Cushing’s syndrome (ECS) remains a diagnostic challenge. Currently available tests lack sufficient sensitivity and specificity or are invasive and technically difficult. Recently, an ACTH-UFC index has been proposed to differentiate the two forms of ACTH dependent Cushing’s syndrome (CS) (Ding, 2021). This work aimed to confirm the diagnostic utility of the ACTH-UFC index to differentiate C...

ea0090ep1096 | Late Breaking | ECE2023

Subtypes of gestational diabetes based on indices of insulin sensitivity and insulin secretion

Fernandez Valero Andrea , Maria Linares Pineda Teresa , Lima Rubio Fuensanta , Molina Vega Maria , Gutierrez Repiso Carolina , Pena Montero Nerea , Suarez Arana Maria , Maria Fernandez Ramos Ana , J Tinahones Francisco , Jose Picon Cesar Maria , Morcilo Sonsoles

Objectives: Some authors have defined subtypes within gestational diabetes (GD) based on the calculation, from glucose and insulin levels during oral glucose overload (OGTT), of indices of insulin sensitivity (Matsuda) and insulin secretion (Stumvoll). Powe et al [1] found that 30% of women with GD had predominantly low insulin secretion, 51% low insulin sensitivity and 18% both (mixed). The aim of this work is to analyze the correlation of these indices with other kn...

ea0063p1106 | Pituitary and Neuroendocrinology 3 | ECE2019

Analysis of gender-related differences in clinically non-functioning pituitary adenomas

Aguirre Moreno Nerea , Sampedro-Nunez Miguel , Levi Ana Ramos , Centeno Rogelio Garcia , Carrera Concepcion Blanco , Escola Cristina Alvarez , Novoa Paz de Miguel , Gutierrez Maria Calatayud , Librizzi Soledad , Azpiroz Monica Marazuela

Introduction: Clinically non-functioning pituitary adenomas (NFPA) are heterogeneous group. Some previous research has found that this type of pituitary adenomas may be smaller and have better prognostic in men. The aim of this study is to analyze if there are gender-related differences in NFPA.Material and methods: Retrospective study of patients with NFPA followed up in regional hospitals (Community of Madrid, Spain). All NFPA had molecular analysis. T...

ea0049ep574 | Diabetes complications | ECE2017

Characteristics of patients with cystic fibrosis and hydrocarbon alteration in an adult unit

Gonzalez Elena Fernandez , Moreno Nerea Aguirre , Caceres Layla Diab , Gutierrez Carmen Acosta , Ramos-Levi Ana , Nunez Miguel Sampedro , Moreno Isabel Huguet , Azpiroz Monica Marazuela , Moreno Rosa Maria Giron , Martin Alfonso Arranz

Introduction: Hydrocarbon Alteration (HA) is considered as the most common complication in Cystic Fibrosis (CF) and is related to a further deterioration of the lung function and the nutritional status.Objective: Analyze the prevalence of HA in patients with CF in an adult unit and its relationship with pulmonary complications.Material and methods: We conducted a retrospective study with 71 patients of our CF unit (age 30+/−9...

ea0049ep1072 | Pituitary - Clinical | ECE2017

Risk factors for progression of the surgical remnant of non-functioning pituitary adenomas in patients treated with dopamine agonists

Gonzalez Elena Fernandez , Nunez Miguel Sampedro , Levi Ana Ramos , Caon Ana Rabe , Hughet Isabel , Moreno Nerea Aguirre , Sanchez Clara Marijuan , Peris Begona Pla , Nieto Angeles Maillo , Andres Alicia Vicuna , Flores Pedro Martinez , Azpiroz Monica Marazuela

Introduction: Surgery is the treatment of choice for non-functioning pituitary adenomas (NFPA), but remnants are frequently observed. Management of these remnants include observation (OBS), radiotherapy (RT) and/or dopamine agonist (DA) therapy. In this study, we evaluate the progression-free survival (PFS) of NFPA with postoperative remnant and the potential factors involved.Methods: We performed a single-center ambispective study of a cohort of 72 pati...

ea0070aep488 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Evaluation of the results obtained with flash continuous glucose monitoring in patients with type 1 diabetes after a structured training program

Pla Peris Begoña , Ramos Leví Ana M , Lahera Vargas Marcos , Carraro Casieri Raffaele , Aguirre Moreno Nerea , Knott Torcal Carolina , Marazuela Mónica , Arranz Martín Alfonso

Introduction: Funding of continuous glucose monitoring (CGM) has been established by Madrid Health Service for adults with type1 Diabetes Mellitus (DM) who meet specific criteria. This has brought to lightthe need foran increasedinvestment in care time. In our Division, a structured training program has been established, consisting of 2 training sessions (TS); the first one based on basic contents to initiateFlash-CGM, and the second one, more intensive and targeted, focused o...

ea0070aep625 | Pituitary and Neuroendocrinology | ECE2020

Malignant insulinoma treated with 177Lu-DOTATATE: Results in the first year post-therapy

Concepción Terroba-Larumbe María , Maria Palacio-Mures Jose , Crespo-Soto Cristina , Perez-Saborido Baltasar , Crespo-Herrero Guillermo , Ventosa-Viña Marta , Acuña-Garcia Manuel , Alejo-Ramos Mirian , Anacabe-Goyogana Itziar , Cuellar-Olmedo Luis

Introduction: Neuroendocrine tumors (NETs) are rare and their clinical behavior and prognosis correlates with mitotic rate and Ki-67 index. Most patients with advanced NET have liver metastases unresectable and somatostatin analogues are the initial therapy of choice but when disease progresses despite treatment and there are positive somatostatin receptors, peptide receptor radioligand therapy (PRRT), using lutetium-177, is a therapeutic option.Clinical...