Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep1040 | Thyroid (non-cancer) | ECE2015

Sensitivity and specificity of thyroid cytology in the diagnosis of malignancy: results of a series of 1567 thyroidectomies

Ma Calderon Dulce , Herraiz Sandra , Sastre Julia , Gonzalez Abel , Fernandez Belen , Valero Miguel Angel , Aguirre Miguel

Introduction: Sensitivity and specificity of thyroid cytology in our series of thyroidectomies were evaluated.Material and methods: A retrospective, multicentre study of 1567 thyroidectomies performed in the eight hospitals of Castilla La Mancha (Spain) during the years 2010–2013.Results: The cytological results were benign in 37.6% of cases, malignant or suspicious of malignancy in 17.3% (10 and 7.3% respectively). In 4.1% of...

ea0035s11.2 | Long term outcome of cured pituitary patients | ECE2014

Quality of life in patients with non-functioning pituitary adenomas

Capatina Cristina , Christodoulides Constantinos , Fernandez Alberto , Cudlip Simon , Grossman Ashley , Wass John , Karavitaki Niki

Non-functioning pituitary adenomas (NFA) are associated with significant morbidity. Published data on the quality of life (QoL) of NFA patients are scarce and conflicting: some studies indicate a reduced QoL in patients with adequately treated NFAs while others demonstrate that subjective health-related QoL is not compromised to any major extent compared to the general population. Most published studies indicate specific subgroups of patients which are particularly affected, w...

ea0035p90 | Bone and Osteoporosis | ECE2014

Familial hypocalciuric hypercalcemia: an important differential diagnosis from hyperparathyroidism

Luque-Fernandez Ines , Vicente Almudena , Luque Alessandra , Del Val Florentino , Garin Intza , Morlan Miguel Angel

Introduction: Familial hypocalciuric hypercalcemia (FHH) is a rare, benign, autosomal dominant condition usually caused by heterozygous inactivating mutations in the gene encoding the calcium sensing receptor (CASR).Case: 22-year-old woman referred to endocrinology for suspected polycystic ovary syndrome. Hypercalcemia is detected. Laboratory tests showed persistent hypercalcemia with a serum total calcium of 11.1 mg/dl (8.8–10.2), phosphorus 2.8, i...

ea0035p400 | Diabetes (epidemiology, pathophysiology) | ECE2014

Impact of Impaired Fasting Glucose on Blood Pressure and Vascular Risk Profile of Normotensives and Untreated Hypertensive Subjects

Fernandez-Garcia Jose Carlos , Cortes-Salazar Carmen Maria , Blanca-Martos Lourdes , Aranda-Lara Pedro

Objective: To evaluate possible differences in 24 hours blood pressure (BP) and vascular risk profile (VRP) of normotensive (NT) and untreated hypertensive (UHT) patients with normoglycemia (NG) or Impaired Fasting Glucose (IFG).Design and methods: From 9.812 nondiabetic subjects taken from the Spanish ABPM (Ambulatory Blood Pressure Monitoring) Registry, we compared 24-h BP and VRP differences between patients with NG [n-6,875 (43.3% NT and 56....

ea0035p716 | Neuroendocrinology | ECE2014

Long-term remission and recurrence rates after transsphenoidal surgery for cushing's disease

Moreno Paloma Moreno , Fernandez Julia Silva , Exposito Maria Rosa Alhambra , Moreno Maria angeles Galvez

Objective: Transsphenoidal surgery (TSS) presents the treatment of choice for Cushing’s disease (CD), 95% microadenomas. Remission and recurrence rates vary dependent on tumor size, extension, adenoma visibility on magnetic resonance imaging, and neurosurgical expertise. Remission rates in the postoperative vary between 55 and 85%, with a recurrence of up to 25%. The aim of this study was to describe the rate of remission and recurrence of CD in our midst after TSS, and c...

ea0035p731 | Neuroendocrinology | ECE2014

Influence of the exon 3 deletion of GH receptor and IGF1 level at diagnosis on the efficacy and safety of treatment with somatotropin in adults with GH deficiency

Andujar-Plata Paula , Fernandez-Rodriguez Eva , Quinteiro Celsa , Casanueva Felipe , Bernabeu Ignacio

Introduction: Human recombinant growth hormone (hrGH) treatment in adult patients with GH deficiency (GHD) has an important interindividual variability and several factors can influence it. The aims of the study were: i)- to analyze the genotype of GHR regarding exon 3 deletion (d3-GHR) in a serie of adult patients with GHD; ii)- to assess the effect of d3-GHR on initial IGF1 levels; iii)- to evaluate if d3-GHR and/or initial IGF1 levels were associated with adverse effects an...

ea0035p1074 | Thyroid (non-cancer) | ECE2014

High-resolution thyroid nodule clinic: analysis of 1674 thyroid nodules

Fernandez-Garcia Jose Carlos , Cortes-Salazar Carmen Maria , Mancha-Doblas Isabel , Tinahones Francisco

Background and objectives: The finding of a thyroid nodule is a very common occurrence in clinical practice. Management of thyroid nodules requires a multidisciplinary approach that may be eased by a high-resolution thyroid nodule clinic. We report our clinical experience and outcomes in a high-resolution thyroid nodule clinic.Materials and methods: We conducted a retrospective analysis of 1674 thyroid nodules evaluated in a high-resolution clinic from a...

ea0070aep521 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Baseline characteristics of a cohort of type 1 diabetes patients on continuous subcutaneous insulin infusion therapy. Evaluation of glycemic variability parameters and complications.

Lecumberri Pascual Edurne , Bengoa Rojano Nuria , Fernandez Argüeso Maria , Lia Nattero Chavez Maria

Introduction: Glycemic variability (GV) has been associated, regardless to A1C levels, to chronic complications of diabetes mellitus (DM).Objective: To describe baseline characteristics, GV parameters, and microvascular complications rates in a selected simple of type 1 diabetes patients (T1DM) on continuous subcutaneous insulin infusion (CSII).Methods: We performed a retrospective observational study with 130 T1DM patientson (CSII...

ea0032p356 | Diabetes | ECE2013

Risk factors for impaired glucose tolerance and diabetes mellitus after liver transplantation

Martinez Guillermo , Allo Gonzalo , Fernandez Ana , Aramendi Mercedes , Jimenez Carlos , Moreno Enrique , Hawkins Federico

Risk factors involved in new-onset diabetes mellitus after transplantation (NODAT) remain unclear. Clinical studies have demonstrated the association between low vitamin D levels with insulin resistance and diabetes. In animal models, osteocalcin deficiency leads to high glucose levels and insulin resistance.The aim of this study is to evaluate the prevalence of NODAT and other alterations of glucose metabolism after liver transplantation (LT) at our ins...

ea0032p357 | Diabetes | ECE2013

Acute exercise leads to increased HbA1c and fructosamine levels in athletes with type 1 diabetes

Forga Luis , Goni Maria Jose , Chinchurreta Laura , Lafita Franciso Javier , Iriarte Ana , Manuel Fernandez- Real Jose

Introduction: In patients with type 1 diabetes, exercise has not consistently been shown to improve glycemic control, as measured using HbA1c levels. Participation in competitive sports may even worsen glycaemic control. Free radicals and oxidative stress markers are known to increase during acute exercise in parallel to decreased circulating antioxidant concentrations. We aimed to analyze the effects of chronic and acute exercise on circulating HbA1c and fructosamine levels.<...