Endocrine Abstracts

Background and aims: Transition of patients with type 1 diabetes (DM1) from pediatric to adult care is challenging and international guidelines recommend effective transition programs. The aim of this study is to describe our baseline situation, without a structured transition program, and to identify factors associated with worse glycemic outcome.Materials and Methods: This is an observational, retrospective study of patients with DM1, aged 14 or more o...

Objective: Flash glucose monitoring (FGM) allows non-invasive glucose level assessment. Our objective was to describe the characteristics of patients in a secondary referral hospital and their glycemic control expressed as FGM targets.Methods and patientsObservational longitudinal clinical study between January 2021 and December 2021 in patients with DM1 referred to a secondary care center in Montilla (Córdoba).Results: 101 patients included. Mean a...

Perturbation of thyroid hormone (TH) function during prenatal brain development can cause a spectrum of neurological disorders as evident in pediatric patients with untreated congenital hypothyroidism or patients with mutations in THRA and SLC16A2 genes. However, scarcity and inaccessibility of human brain tissue from early developmental stages has been a major roadblock for experimental approaches to decipher local TH action in early development. Advanced <e...

Thyroid hormones (TH) play a fundamental role in brain development. Changes on TH availability during pregnancy and early childhood can lead to neurological disorders. Accordingly, concerns are mounting that exposure to environmental compounds capable of interfering with TH action can disrupt neuronal development. Current approaches to categorize chemicals as thyroid hormone system disrupting chemicals (THSDC) are mainly based on determination of changes in circulating TH conc...

Thyroid hormones (TH) play a critical role during nervous system development and patients carrying coding variants of THRA or SLC16A2/MCT8 genes present a spectrum of neurological phenotypes presumably resulting from perturbed local TH action during early brain development. Monocarboxylate transporter MCT8 is a well-characterized TH membrane transporter and MCT8 mutations have been associated with the Allan-Herndon-Dudley Syndrome. Recent advances in stem cel...

Objective: To evaluate the impact of a decision support system (DSS) based on artificial intelligence (AI) -KoiosDS- on ultrasound (US) image analysis and risk stratification in thyroid nodules. Material and methods Retrospective US study of all thyroid nodules with histologic (AP) result from June 2020 to December 2021. Diagnostic performance of US with ACR-TIRADS, by four endocrinologists and DSS, before and after the use of AI was evaluated.Results: A...

Objectives: To analyze the data of patients seen at the Diabetes and Pregnancy Unit, assessing the frequency of pregnancy planning and whether there are differences in the degree of metabolic control before and during pregnancy, as well as in perinatal outcomes with respect to those who do not plan. All women of childbearing age with Pregestational Diabetes Mellitus(PGDM) should receive preconception counseling to optimize glycemic control, since preconception control is assoc...

Introduction: DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome is a severe multiorgan drug reaction, often associated with the development of autoimmune diseases. Pathogenically it has been related to the reactivation or the primary infection of different herpes virus.Clinical case: A 33-year-old woman with a history of residual epilepsy, after resection of a cerebellar pleomorphic xantoastrocytoma, started treatment with Levetirace...

Introduction: The aim of this study was to analyze the effects of Liraglutide in hepatic steatosis as well as clinical and biochemical data before and after 6 months.Methods: We have retrospectively analysed epidemiological, anthropometric and laboratory data of 83 type 2 diabetic patients treated with Liraglutide and followed at different endocrinology units across east Andalusia. We have evaluated nonalcoholic fatty liver disease using liver enzymes an...

Introduction: A multidisciplinary clinic has been developed to optimize the diagnosis and treatment of bone metabolism diseases. Initiated in March 2013, it is carried out simultaneously, once a week by an Endocrinologist and a Rheumatologist.Objective: To describe the experience of this unit in the last 12 months.Material and methods: Cross-sectional observational study. 235 patients were attended from December 2015 to December 20...