Endocrine Abstracts

Introduction: Generously supported by IPSEN)-->Prolactin (PRL) -secreting adenomas are about 40% of all pituitary adenomas. Their clinical symptoms are mainly related to development of secondary hypogonadism and/or tumor mass effects. Dopamine agonists (DA) are first-line drugs for prolactinoma patients due to their effectiveness in normalizing PRL levels and shrinking tumour mass. Surgery is an option for DA failure or tumour mass e...

Introduction: Thyroid volume (TV) depends on age, gender, anthropometry, smoking and iodine status. IGF1 plays a role on thyroid growth, as demonstrated in acromegaly and GH-deficiency. Finally, TSH is a well recognised permissive factor for thyroid tissue growth. The aim of the study is to evaluate the long-term effect of TSH-deficiency on TV in hypopituitaric patients compared with healthy volunteers.Methods: We performed a cross-sectional, controlled ...

Introduction: Cinacalcet is an oral calcimimetic indicated in treatment of primary hyperparathyroidism if patients do not accept surgery, do not carry out the surgical criteria, there is failure of previous surgery or serious comorbidity that makes surgery impossible.Methods: Descriptive study that included 34 patients with primary hyperparathyroidism treated with cinacalcet. We recorded clinical and biochemical data before and after 6 months of treateme...

Introduction: Cross-sex hormone treatment (CHT) in male-to-female (M2F) transsexuals affects the hemostatic balance, with the emergence of a prothrombotic state with the use of certain estrogen (oral ethinyl estradiol vs 17β estradiol). Testosterone administration to F2M transsexuals had an antithrombotic effect. In female-to-male in (F2M) transsexuals administration of testosterone seems to carry a mild antithrombotic effect.Objective: To quantify ...

Introduction: Neuroendocrine tumors (NETs) over-express somatostatin receptors (SRs) and the efficacy of peptide receptor radionuclide therapy (PRRT) with somatostatin analogues labeled with high activities of β-emitting radioisotopes has been reported.Aim: Ongoing study to evaluate efficacy and toxicity of combination treatment with 4 cycles of radiolabeled DOTATATE, alternating 177Lu and 90Yin patients with metastasised NETs expressing SRs refract...

Pseudohypoparathyroidism (PHP) refers to a heterogeneous group of rare metabolic disorders characterized by hypocalcemia and hyperphosphatemia due to PTH resistance. Heterozygous loss of function mutations in the gene encoding the alpha-subunit of Gs (GNAS) inherited from the mother lead to PHP type Ia. PHP type Ia (PHP-Ia) is a disease in which the physical features (short stature, obesity, round face, brachydactyly and subcutaneous ossifications) that constitute Albri...

Chronic obstructive pulmonary disease (COPD) patients could have altered endocrine function as different endocrine organs (gonads, pituitary, thyroid and pancreas) can be affected depending on the phenotype of the disease and the degree of systemic inflammation. Anabolic hormones can be involved as COPD patients can show weight loss and muscle wasting and both these conditions can modify natural history of the disease. Moreover COPD patients can frequently have acute exacerbat...

Introduction: Obesity related glomerulopathy (ORG) is an emerging epidemic alongside increasing incidences of obesity. ORG pathophysiology has not been explored despite poor prognosis in untreated patients. MCP-1, MIF, CCL-18 and CCL-15 are novel cytokines that may be pathologically involved in obesity-induced renal injury and explored in this study.Methods: Blood pressure, urine and blood samples were collected from 34 morbidly obese patients before and...

Idiopathic central hypogonadism (ICH) is a rare and heterogeneous disease due to defects of GnRH secretion or action. Depending on the association with a normal or defective sense of smell, ICH could be respectively identified as normosmic ICH (nICH) or Kallmann’s syndrome (KS). Recent experimental evidences indicate the involvement of the new PROK2/PROKR2 pathway in GnRH neuron maturation and function and mutations affecting these two genes have been described in some IC...

BRAFV600E mutation is considered useful in recognizing thyroid cancer aggressiveness or poor prognosis particularly in certain variants of papillary thyroid cancinoma (PTC). A recent meta-analysis identified 12 cancer-versus-non cancer gene candidate as markers of thyroid cancer; among these TIMP-1 (tissue inhibitors of metalloproteinases) was found consistently up-regulated. Our aim was to evaluate BRAFV600E mutation and TIMP-1 expression in 14 PTC class...