Searchable abstracts of presentations at key conferences in endocrinology

ea0081oc10.3 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Glucose-dependent insulin secretion is regulated by mitochondrial-associated cannabinoid receptor type 1 (mtCB1)

Allard Camille , Zizzari Philippe , Clark Samantha , Dupuy Nathalie , Bermudez-Silva Francisco-Javier , Delgado Concepcion Lillo , Bellocchio Luigi , Marsicano Giovanni , Quarta Carmelo , Cota Daniela

Type 2 diabetes is among the most prevalent chronic diseases worldwide. Further research is needed to identify new mechanisms that may help preserve the function of insulin-secreting pancreatic β-cells. The cannabinoid receptors type 1 (CB1) and their endogenous ligands, endocannabinoids, exert a key role in regulating of glucose homeostasis, β-cells function, and insulin secretion. Intriguingly, CB1 is not only located at the plasma membrane (pmCB1), but also at the...

ea0081p57 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Diagnosis of gestational diabetes mellitus in the COVID-19 pandemic: comparative analysis of women with positive O’Sullivan test in the same trimester of 2019 and 2020

Ignacio Martinez Montoro Jose , Jose Simon Frapolli Victor , Molina Vega Maria , Espina Sonsoles Morcillo , Suarez Arana Maria , Tinahones Francisco J. , Jose Maria , Cesar Picon

Introduction: In May 2020, during the COVID-19 pandemic, the Spanish Group of Diabetes and Pregnancy published a consensus document establishing the alternative diagnostic criteria for gestational diabetes mellitus (GDM) in case of impossibility to perform the two-step traditional approach due to the COVID-19 sanitary emergency. This study aims to compare different characteristics of pregnant women who tested positive in the O’Sullivan test in the same pregnancy trimester...

ea0081p368 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Comparative analysis of clinical, obstetric and perinatal characteristics of pregnant women according to serum levels of vitamin D

Simon Frapolli Victor Josa , Fernandez Valero Andrea , Fuentes Miguel Damas , Molina Vega Maria , Picon Casar Maria Josa , Tinahones Madueno Francisco Josa

Introduction: Vitamin D is considered a fat-soluble vitamin and a fundamental prohormone in mineral and bone metabolism, with an immunoregulatory, cardiovascular and neuroprotective effect, among others. Vitamin D can be found as vitamin D2 or ergocalciferol and vitamin D3 or cholecalciferol. The main source of vitamin D comes from ultraviolet radiation in sunlight, but it is also obtained through food. Vitamin D deficiency is very prevalent in Europe, with a significant peak ...

ea0081p240 | Thyroid | ECE2022

Development of a laboratory alerting system for the early diagnosis of thyroid dysfunction in pregnancy

Ignacio Martinez Montoro Jose , Jose Simon Frapolli Victor , Fernandez Valero Andrea , Molina Vega Maria , Cobos Andres , Tinahones Francisco J. , Jose Picon Cesar Maria

Introduction: Overt thyroid dysfunction in pregnancy without an early diagnosis and treatment may lead to an increased risk of adverse maternal and fetal outcomes. In this study, our goal was to assess the results of the development of a laboratory alerting system for the diagnosis of thyroid dysfunction in the first trimester of pregnancy. Material and methods: Observational retrospective study evaluating clinical and biochemical data from pregnant wome...

ea0081ep252 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Comparative analysis of characteristics of pregnant women with pathological oral glucose tolerance test vs negative oral glucose tolerance test in a trimester of 2019

Simon Frapolli Victor Jose , Ignacio Martinez Montoro Jose , Picon Cesar Maria Jose , Gutierrez Repiso Carolina , Suarez Arana Maria , Tinahones Madueno Francisco Jose , Molina Vega Maria

Introduction: Gestational diabetes mellitus (GDM) is the metabolic disorder most frequently associated with pregnancy, presenting important maternal and fetal implications. Strict glycemic control through lifestyle measures and/or pharmacotherapy is essential to achieve adequate obstetric-perinatal results. The objective of this study is to compare baseline characteristics and perinatal results in patients diagnosed with GDM after performing oral glucose tolerance test (OGTT) ...

ea0081ep258 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The effect of mimic-mir-21/au@ nanosystem on browning activation: a possible therapeutic tool against obesity

Lhamyani Said , Gentile Adriana-Mariel , Giraldez Perez Rosa Maria , Grueso Elia , Mengual Mesa Maria , Estepa Enrique , Olveira Gabriel , Tinahones Francisco-Jose , Bekay Rajaa El

Background and aim: Obesity is a chronic disease associated with a positive energy balance leading to lipotoxicity, which contributes to the onset of obesity-associated metabolic disorders such as type 2 diabetes and insulin resistance. It’s well known that thermogenesis in brown adipose tissue (BAT) and “browning” of white AT (WAT) increase energy expenditure, thus promoting weight loss and protect against obesity. Recently, the microRNAs (miRNAs) that regulate...

ea0081ep998 | Thyroid | ECE2022

Thyroid disease in patients with type 1 diabetes

De Carlos Joaquin , Basterra Francisco Javier , Terreros Amaya Sainz De Los , Garcia Javier , Garcia Marta , Iriarte Ana , Marti Miguel , Jose Goni Maria

Introduction: An increased risk of thyroid disease (TD) has been described in patients with type 1 diabetes (DM1) with respect to the general population. The objective is to establish the incidence and characterize the differences in patients who develop TD in relation to the debut of DM1 (previous, concurrent or a posteriori).Materials and methods: Retrospective study of 1126 patients followed up in Endocrinology consultations in Navarra. Three types of...

ea0090p78 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Epicardial Fat, a cardiovascular risk factor with implications in kidney function

Perdomo Carolina M. , Martin-Calvo Nerea , Ezponda Casajus Ana , Mendoza Francisco J. , Bastarrika Aleman Gorka , de Assuncao Guilherme V. , Garcia-Fernandez Nuria , Fruhbeck Gema , Escalada Javier

Aim: Epicardial adipose tissue (EAT) has important physiologic functions, nonetheless, excessive EAT leads to a proinflammatory state with adverse effects on the myocardium. EAT has also been associated with adverse outcomes in chronic kidney disease (CKD) patients. We think that visceral adipose tissue (VAT) and organ-specific ectopic fat plays an important role in cardiorenal dysfunction. The aim of our study is to analyse the relationship between EAT and the risk of develop...

ea0090p603 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Strategic Designs to identify the best housekeeping genes for the characterization of biomarkers in adipose tissue of patients with obesity and cancer

Perez Gomez Jesus , Porcel-Pastrana Francisco , de la Luz Borrero Marina , Gahete Manuel D. , Guzman Rocio , Malagon Maria , Luque Raul M.

Obesity (OB) is caused by an energy imbalance that finally leads to adipose tissue dysfunction, and the appearance of multiple comorbidities, such as certain cancer types, including prostate cancer (PCa), which is one of the leading causes of cancer-related death in men population worldwide. In this context, periprostatic adipose tissue (PPAT) has recently gained increased attention as a key regulator of the pathophysiological relationship between OB and PCa. However, it has b...

ea0090ep256 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Influence of diabetes mellitus on changes in preperitoneal fat measured by nutritional ultrasound, in a cohort of patients who required intensive care unit (ICU) admittance due to severe covid-19 pneumonia, during a 6-month follow-up program

Simon Frapolli Victor Jose , Aguilar Isabel Vegas , Rosa Victoria Gonzalez , Sanchez Garcia Ana Maria , Tinahones Madueno Francisco Jose , Garcia Almeida Jose Manuel

Introduction and Objectives: Preperitoneal fat is an ectopic visceral adipose tissue with a significant proinflammatory metabolic impact. The objective of this study is to measure preperitoneal fat by nutritional ultrasound at discharge, 3 months and 6 months in a cohort of patients who required admission to the Intensive Care Unit (ICU) due to severe COVID-19 pneumonia, and to analyze the differences based on the presence or not of previous DM.Material ...