Endocrine Abstracts

Objective: ACTH-secreting pituitary tumors (ACTHomas) express vasopressin (AVP) receptors. AVP receptors are also present in other types of cancer, exerting different effects on tumor growth depending on the receptor subtype. AVP type 1 receptors (V1a and V1b) are associated with stimulation of cell proliferation, AVP receptor type 2 (V2r) is associated with antiproliferative effects. Desmopressin (DAVP) is a synthetic analog of AVP that acts as a selective agonist for V2r, wh...

Objective: The carbohydrate metabolism dysfunctions are common in critical ill patients with diabetes or stress hyperglycaemia and the correct management of them has an important prognostic value. Despite its limitations, capillary glucose (CG) was collected more than arterial glucose (gold standard) because of its good correlation. However, the usefulness of intermittent intersticial glucose monitoring (IGM) in keeping blood glucose within target range in critical ill patient...

Objective: Adrenal venous sampling (AVS) is a reliable procedure to differentiate if in patients with primary aldosteronism (PA) aldosterone production is unilateral or bilateral and guide treatment of these patients. Our objective was to describe their characteristics and the outcomes of the AVS.Methods and patients: Observational longitudinal clinical study between July 2020 and November 2022 in patients who underwent AVS in our Hospital.<p class="...

Objective: Flash glucose monitoring (FGM) facilitates non-invasive glucose level assessment. Since November 2020 this system is subsidized in patients with type 3c diabetes (DM3c) Our objective was to describe the characteristics of these patients and their glycemic control expressed as times in range.Methods and patients: Observational longitudinal clinical study between January 2021 and January 2023 in patients with DM3c.Results:...

Objective: Preclinical studies have shown that DPP-4 inhibitors (iDPP4) have beneficial effects on functional mass of beta cells and pancreatic insulin content. The aim of this study is to evaluate the efficacy of treatment with sitagliptin in monotherapy or in combination with insulin in person with type 1 diabetes (DM-1) or type LADA diabetes (DM-LADA) of recent diagnosis.Patients and methods: Descriptive study: patients with DM-1 or DM-LADA in treatme...

Introduction: Bariatric surgery has important metabolic complications such as bone mass loss.Goal: To assess bone mineral density (BMD) after Roux-en-Y gastric by-pass (RYGB) in patients under standard calcium and vitamin D supplementation.Method: In patients with morbid obesity submitted to RYGB, we measured BMD with a dual X-ray densitometer. Using World Health Organization (WHO) criteria’s, values were compared with young c...

Introduction and objectives: Metformin (MTF) is the most used oral antidiabetic drug for the treatment of type 2 diabetes (T2D). However, intolerance to drug is frequent and limits its use. There are controversies about the cause of this problem, the gut microbiota has been proposed to be responsible. The gradual introduction of MTF could exercise an adaptation of gut microbiota that would facilitate tolerance to MTF. In this study we evaluate the metabolic changes and gut mic...

Aim: Describe the control of cardiovascular risk factors (CVRF) in patients with diabetes and myocardial infarction (MI) as well as their treatment and control.Patients and methods: Observational retrospective study of a cohort of patients with diabetes admitted to the cardiology department because of a MI between November 2015 and November 2016. Statistical analysis performed with SPSS 24th version.Results: 421 patients admitted b...

Introduction: Thyroid nodules are very common in the general population (20–75% ultrasound). There are clinical management criteria established by international societies and standardized cytological diagnostic criteria (Bethesda). However, there is still uncertainty in the management of category 3 (follicular lesion of undetermined significance). Objectives: To evaluate the clinical attitude to the cytological diagnosis of Bethesda category 3 (B3) in thyroid fine-needle ...

Aim: To describe the follow-up of adrenal incidentalomas (AI) classified as non-functioning and no suspicious for malignancy in the first approach.Patients and methods: Observational retrospective study of a cohort of patients who consulted in the Endocrinology service between 2005 and 2015 because of an AI. Statistical analysis performed with SPSS 19th version.Results: Two hundred and one patients with IA were firstly evaluated. T...