Endocrine Abstracts

Introduction: Neutropenia can indicate infectious and hematological pathology but it can also be a sign of hyperthyroidism. For this reason, it has been suggested to perform a complete blood count before starting treatment with antithyroid drugs in case of new-onset hyperthyroidism. Antithyroid drugs can cause severe neutropenia, also called agranulocytosis, when the neutrophil count is less than 500/µl. Therefore, the use of these drugs should be reconsidered if it is le...

Introduction: Salivary cortisol measurement is a non-invasive and easy test to carry out. It is painless and does not cause stress.Aim: The aim of the present study was to evaluate the correlation between salivary cortisol (SaC) and serum cortisol (SeC) after 1 mg Dexamethasone (DXM) overnight and their diagnostic utility as screening test of Cushing’s syndrome (CS).Methods: We performed a prospective study in 92 patients with...

Introduction: Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (classic 21-OHD CAH) is the most common form of congenital adrenal hyperplasia, characterized by simple virilizing or salt wasting forms. The saline loss picture develops after birth and it can evolve in a short time to a severe picture of hypotonic dehydration and hypovolemic shock with lethal consequences if not diagnosed and treated. Herein we present an unusual case of classic 21-OHD CAH ...

Introduction: Hypophysary aneurysms are rare, they account for 1% to 2% of all intracranial aneurysms (1) and can be mistaken for pituitary adenomas, since they can have similar symptoms and even radiological signs especially if it’s an aneurysm completely thrombosed as angiography will show only avascular mass (2).Clinical case: A 84 year old female with past medical history of hypertension, dyslipidemia and depressive disorder, presents to emergen...

Introduction: Esthesioneuroblastoma is an uncommon malignant neoplasm with an average 5-year survival rate of about 45%. Ectopic ACTH syndrome due to esthesioneuroblastoma is extremely rare and there have been very few cases reported.Case report: A 54-year-old woman was admitted to our hospital with symptoms of leg edema and general fatigue of one month’s duration. Physical examination showed moon facies and edema on her lower extremities bilaterall...

Introduction: Hyperthecosis ovarian is a type of hyperandrogenism and severe insulin resistance, usually found in postmenopausal women.Case Report: This case is about a 12 year-old girl who came to our hospital because of a rapidly progressive virilization. She had no medical history. For the previous 10 months, she had felt progressive growth of terminal hair in androgen-dependent areas, abundant hair loss, facial acne and voice changes. Axilarche and p...

Primary hyperparathyroidism (PHPT) is frequently diagnosed as an incidental finding of hypercalcemia. Overt bone disease (osteitis fibrosa cystica or brown tumor), with history of pathologic fractures is a rare presentation.A 48-year-old woman was admitted in with pain in the right thigh after a trivial fall. She also complained of generalized weakness and lethargy over the last 2 years. Her medical history mention multiple bone fractures in the last 6 y...

Purpose: In the recent study it has been reported, that elevated serum concentrations of TSH receptor (TSH-R), antithyroglobulin (Tg), antiperoxidase (TPO) autoantbodies (Abs) may be observed in the subjects treated for amiodarone induced thyrotixicosis (AIT) type I, decreased in type II of AIT, or changed in amiodarone induced hypothyroidism (AIH). This study was done to analyse the changes of Tg-Abs, TPO-Abs and TSH-R-Abs titer in euthyroid, hyperthyroid (AIT), and hypothyro...

Objective: Male hypogonadism is common in the elderly and has been associated with increased risk of mortality. Our objective has been to assess the prevalence of primary and central hypogonadism in elderly male patients admitted to the hospital because of acute illness. We also evaluated the relationships between gonadal dysfunction and in-hospital mortality.Patients and methods: 150 male patients, aged ≥65 years, admitted during 2010 and 2011 in ...

Introduction: Radioiodine (RAI) therapy is a standard procedure in therapy of hyperthyroidism. However, the use of RAI in euthyroid patients requiring chronic administration of amiodarone (AM), in a case of lacking efficacy of other antiarrhythmic drugs might be controversial.Objective: The aim of the study was to assess the safety and efficacy of an AM therapy prior to treatment with radioiodine therapy in euthyroid patients with permanent atrial fibril...