Endocrine Abstracts

Introduction: Adiponectin is an adipocyte-derived hormone with an important role in regulation of glucose and lipid metabolism. Its variation might mediate an ameliorated metabolic profile associated with weight loss after bariatric surgery. The aim of our study was to evaluate adiponectin change as early as 6 months after laparoscopic sleeve gastrectomy (LSG) and to indicate preoperative factors that might influence its dynamic.Methods: A number of 88 e...

The aim of our study was to assess the relation between common carotid intima-media thickness, a marker of subclinical atherosclerosis and other metabolic risk factors, in a group of obese patients.Patients and methods: Of 142 obese patients (47 male, 95 female, mean age 39.74±11.41 years, and mean BMI 46.88±8.85 kg/m2) were clinically and biologically evaluated. BMI and waist circumference were measured and a complete patient histor...

Aim: The aim of the study was to evaluate the relation between anthropometric measurements, plasma biomarkers of inflammation, metabolic and adipokines pattern and the presence of severe steatosis, in a group of patients with morbid obesity.Materials and methods: We evaluated a group of 40 patients (25 F, 15 M) with morbid obesity and indication for bariatric surgery. Anthropometric measurements (waist circumference, BMI determination) were performed and...

The objective of the study was to evaluate the prevalence of secreting profile among a series of subjects with incidental discovered adrenal tumors. Subjects. 139 subjects (112 women and 27 men) diagnosed with adrenal tumors between 2010 and 2015 in our department.Methods: Medical records were retrospectively analysed for demographic data, routine tests, specific adrenal hormones measurements, associated diseases.Results: Regarding...

Introduction: Meningiomas, already one of the most frequent types of primary central nervous system tumors, have been increasing in incidence in the past decade. Considering their location and histologic particularities, radiation therapy (RT), alone or in combination with neurosurgery, is often necessary and can have a negative impact on adjacent structures such as the pituitary gland. More studies investigating the endocrinologic disturbances in this pathology are necessary ...

Background: Renal dysfunction is known to be more prevalent amongst patients with obesity. Metabolic and bariatric surgery is associated with positive renal effects through intricate pathways. We aimed to determine the short-term impact of laparoscopic sleeve gastrectomy (LSG) on renal function and to identify parameters associated with its variation.Materials and methods: We performed a retrospective study on 268 patients (115 males and 153 females) eva...

Introduction: Acromegaly is a rare endocrine disease characterised by excess GH produced by a pituitary adenoma. It is associated with several complications and comorbidities. Metabolic alterations such as diabetes and dyslipidemia are quite frequent described in these patients.Materials and methods: This is a retrospective observational cross-sectional study meant to assess the metabolic modifications in a group of acromegaly patients evaluated in our d...

Objectives: Post-surgical hypoparathyroidism (PoSH) is a common long-term complication after thyroid surgery. The reported median incidence rates of temporary and permanent PoSH was 27% and 1% respectively.Methods and results: We retrospectively analyzed the files of 552 patients who underwent thyroidectomy in our surgery department between 2015 and 2017 with the aim to assess the prevalence of PoSH and to identify patient and disease related factors ass...

Background: Acromegaly is a rare severe disease which, untreated, leads to increased cardiovascular and respiratory morbidity and mortality. Pituitary surgery is the first-line therapy, and medical treatment (somatostatin receptor ligands SRLs, dopamine agonists DA, and GH receptor antagonists GHRAs) is indicated for persistent disease. While selected patients are treated with DA and GHRAs, SRLs remain the mainstay of acromegaly therapy.Objective: The ai...

Polycystic ovary syndrome (PCOS) is one of the most frequently encountered endocrine pathologies in women of reproductive age, being regarded as a chronic systemic disease instead of the simple local one. It is frequently associated with insulin resistance, hyperandrogenemia and chronic inflammation. PCOS reunites multiple and diversified pathological combinations like: ovulatory functional disorders directly impacting on the reproductive system, carbohydrate and lipid metabol...