Searchable abstracts of presentations at key conferences in endocrinology

ea0050p384 | Thyroid | SFEBES2017

Urinary Iodine to Creatinine ratio (UI/C) during pregnancy is not associated with adverse obstetric outcomes

Torlinska Barbara , Bah Sarah , Janjua Aisha , Boelaert Kristien , Chan Shiao-Yng

Background: Maternal severe iodine deficiency has been associated with pregnancy and neonatal loss but the impact of mild-moderate iodine deficiency on pregnancy is not well-documented. Mild-moderate iodine deficiency during pregnancy is common even in iodine replete countries. In the UK women of reproductive age have been found to be mildly-to-moderately iodine deficient. UI/C is an optimal indicator for iodine status in pregnancy.Aims: We...

ea0085oc9.3 | Oral Communications 9 | BSPED2022

Diabetes and obesity in down syndrome across the lifespan: a retrospective cohort study using UK electronic health records

Aslam Aisha , Baksh Asaad , Pape Sarah , Consortium Go-DS21 , Strydom Andre , Gulliford Martin , Chan Li

Background: Down Syndrome (DS) is the commonest form of chromosomal trisomy. Genetic factors in DS may increase the risk for diabetes. Obesity and type 2 diabetes mellitus (T2DM) rates have increased in the general populationbut it is not known whether this similarly affected people with DS.Objective: To determine whether DS is associated with increased incidence of diabetes and the relationship with obesity across the lifespan compared to controls.<...

ea0086p364 | Thyroid | SFEBES2022

Evaluating the progression to hypothyroidism in preconception euthyroid thyroid-peroxidase antibody positive women

Dhillon-Smith Rima , Gill Sofia , Cheed Versha , Boelaert Kristien , Chan Shiao , Coomarasamy Arri

Background and aims: Thyroid peroxidase antibody (TPOAb) positivity is prevalent in women of reproductive age and pre-disposes to thyroid dysfunction, namely hypothyroidism, which has adverse effects on pregnancy. The aim of this study was to report the rate of development of abnormal thyroid function among initially euthyroid TPOAb positive women recruited into TABLET trial. To also identify factors associated with the development of hypothyroidism and to compare outcomes bet...

ea0090p247 | Thyroid | ECE2023

Noise Level, Salivary Cortisol Levels and Surgical Team Stress During Thyroidectomy in An Endocrine Surgery Operating Room

Idrees Sarrah , Mayilvaganan Sabaretnam , Bhargav Panchangam Ramakanth , Chan Gyan , Mishra Anjali , Agarwal Gaurav

Introduction: Noise in the operating room is an ongoing problem and impacts the outcome of surgery. Noise as stressor can produce a startle reaction and activate fight or flight response of the autonomic and endocrine system. The psychobiology of the stress as assessed by salivary cortisol level is a sensitive measure of allostatic load. In this study, we correlated salivary cortisol levels of the surgical team with noise measurement and also whether the noise in OR subjective...

ea0065oc4.5 | Thyroid | SFEBES2019

The prevalence of thyroid dysfunction and autoimmunity in women with history of miscarriage or subfertility across the United Kingdom

Dhillon-Smith Rima , Tobias Aurelio , Smith Paul , Chan Shiao , Boelaert Kristien , Coomarasamy Arri

Thyroid dysfunction and autoimmunity are associated with adverse fertility and pregnancy outcomes. International bodies recommend routine thyroid function screening in women with history of subfertility or miscarriage. Knowledge about the frequency of, and risk factors for, thyroid disease is limited in the asymptomatic preconception population. A prospective multi-centre study of women with history of miscarriage or subfertility conducted at 49 hospitals across the United Kin...

ea0065p48 | Adrenal and Cardiovascular | SFEBES2019

Twenty-five years of familial glucocorticoid deficiency: genotypic and phenotypic variability

Smith CJ , Maharaj AV , Prasad R , Hughes C , Qamar Y , Clark AJL , Chan LF , Metherell LA

Within the last 25 years more than 400 cases with suspected Familial Glucocorticoid Deficiency (FGD) have been referred to our centre for genetic testing. All cases had low or undetectable serum cortisol paired with an elevated plasma ACTH level. Our patient cohort comprises 352 families from 30 different nationalities and ranges from neonates to patients in their eighties. In 1993 the first gene defect, in MC2R, was discovered by candidate gene sequencing. Subsequent...

ea0066oc5.9 | Oral Communications 5 | BSPED2019

Rare causes of primary adrenal insufficiency (PAI) in children from Sudan

Qamar Younus , Maharaj Avinaash , Chan Li , AbdulBagi S , Abdullah M , Metherell Louise

Background: Primary adrenal insufficiency (PAI) is a rare, genetically heterogenous condition, characterised by hypocortisolaemia and high plasma ACTH levels in the presence or absence of mineralocorticoid deficiency. PAI can be life-threatening if unrecognised, misdiagnosed or under/untreated. Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive form of PAI characterised by isolated glucocorticoid insufficiency. Mutations in the MC2R/ACTH receptor, ...

ea0042oc1 | (1) | Androgens2016

Non-classical testosterone signaling in the testis

Dietze Raimund , Bulldan Ahmed , Shihan Mazen , Chan Kai-Hui , Konrad Lutz , Scheiner-Bobis Georgios

Although classical and non-classical signaling of testosterone (T) has been observed in the testis, the enigma of the non-classical pathway is not fully resolved. While some researchers favor the androgen receptor (AR), others propose a membrane-bound receptor for non-classical T signaling. Although silencing of the AR in Sertoli cells (SC) resulted in infertility and suggested no involvement of the non-classical pathway, recent experiments using an inhibitor of the non-classi...

ea0041ep453 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Frequency of diabetes and thyroid autoantibodies in patients with type 1 diabetes and their siblings

Kim Chan Jong , Oh Ka Young , Kim Yun Hee , Yang Eun Mi

Background: We investigated the frequency of autoimmune thyroid and diabetes antibodies in patients with type 1 diabetes mellitus (T1DM), their siblings, and controls.Methods: Glutamic acid decarboxylase antibodies (GADA), islet cell antibodies (ICA), insulin autoantibodies (IAA), and thyroid antibodies were identified in all subjects.Results: The rates of positive GADA and IAA were significantly higher in probands compared to sibl...

ea0038p362 | Reproduction | SFEBES2015

Vitamin D metabolic profiling across pregnancy

Susarla Radhika , Jenkinson Carl , Tamblyn Jennifer , Keevil Brian , Chan Shiao-Yng , Kilby Mark , Hewison Martin

Vitamin D-deficiency during pregnancy has been associated with increased complications of pregnancy including a high risk of pre-eclampsia (PET). Current analysis of vitamin D ‘status’ is based exclusively on analysis of maternal serum 25-hydroxyvitamin D3 (25(OH)D3), the circulating precursor form of vitamin D. We hypothesised that comprehensive profiling of vitamin D metabolites may provide a more accurate determination of vitamin D function i...