Endocrine Abstracts

Objective: To evaluate the effectiveness and security of bariatric surgery in metabolically healthy obese (MHO).Methods: A retrospective study of a cohort of all obese patients who underwent to bariatric surgery with a minimum two-year follow-up. Databases of all demographic, anthropometric and metabolic characteristics have been collected since 2007. Patients undergoing two surgeries were excluded. We defined as MHO patients those without diagnosis of d...

Introduction: Various thyroid imaging reporting and data systems (TIRADS) have been proposed in recent years, such as the EU-TIRADS proposed by the European Thyroid Association (ETA). These classification systems intend to estimate the malignancy risk of thyroid nodules, however they are very much based on suspicious ultrasound (US) features typical of papillary thyroid cancer. As such, follicular carcinomas may be reported as low suspicion nodules. Our work aims to evaluate t...

Sex hormone-binding globulin (SHBG) is a circulating plasma glycoprotein produced by the liver, which in the blood binds estrogens and androgens with high affinity and regulates its bioavailability. Low plasma SHBG levels are associated with obesity, metabolic syndrome and non-alcoholic fatty liver disease. Importantly, epidemiological studies have demonstrated that low plasma SHBG levels is a risk factor for developing type 2 diabetes and cardiovascular disease. In the last y...

Background: Sarcopenic obesity(SO) is an entity characterized by excess fat mass(FM) and low muscle mass (LMM) and function. Excess FM itself can lead to loss of muscle mass and function at any age. The combination of obesity and sarcopenia is a proven risk factor for frailty, comorbidities and mortality. New diagnostic criteria have been developed for this entity.Aims: To assess the prevalence and severity of SO with different indices by DXA, in a group...

Aim: Bariatric surgery (BS) modifies body composition. The aim of the study was to establish the first step toward the introduction of the ultrasound (US) and bioelectrical impedance analysis (BIA) in the evaluation of body composition before and after BS. In addition, as obesity was shown to be related to global cognitive decline, we aim to determine possible changes in cognitive test before and after BS.Material and Methods: a prospective pilot study o...

Background: Acute intermittent porphyria (AIP) is an inherited autosomal dominant disorder characterized by hepatic deficiency of hydroxymethylbilane synthase (HMBS)/porphobilinogen deaminase (PBGD), the third enzyme of the heme synthesis pathway. Hyponatremia is one of the main presenting symptoms and it is thought to be related to an inadequate secretion of ADH (SIADH). Since AIP is an uncommon disease, there is little information about how AIP related hyponatremia responds ...

Introduction: Type 1 Gastric neuroendocrine tumors account for 70 to 80 percent of all gastric neuroendocrine tumors (G-NETs) and they are found more commonly in older adults, particularly women. They are associated with autoimmune metaplastic atrophic gastritis (AMAG) with or without pernicious anemia. Endoscopically, they are usually smaller than 1 cm and often multiple. These tumors usually present a non-aggressive evolution. Our goal is to approach the presence of risk fac...

Introduction: Primary hyperparathyroidism (PHP) has been postulated to be a cause of primary hyperaldosteronism (PHA). In fact, PTH receptors have been detected in aldosteronoma tissue. Hyperaldosteronism can also induce elevation of PTH levels, as increased circulating volume increases calciuria, with secondary elevation of PTH levels as serum calcium levels rise. We studied the prevalence of PHP in a group of patients diagnosed with PHA either following or simultaneously wit...

Introduction: Type 1 Gastric neuroendocrine tumors account for 70 to 80 percent of all gastric neuroendocrine tumors (G-NETs) and they are found more commonly in older adults, particularly women. They are associated with autoimmune metaplastic atrophic gastritis (AMAG) with or without pernicious anemia. They are usually smaller than 1 cm and often multiple. Our goal is to describe different characteristics of type 1 G-NETs and to study possible prognostic factors related to th...

Inroduction: Polydipsia -excessive oral intake of liquids, with/without thirst- can induce euvolemic hyponatremia. Adequate inhibition of AVP secretion induced by low plasma osmolality (POsm) is reflected in a urinary osmolality (UOsm) ≤100 mOsm/kg. However, increased fluid intake can also reveal underlying non-osmotic AVP secretion, induced by pain, nausea, and/or SIADH, with UOsm >100. Iatrogenic polydipsia is characterized by increased liquid intake without thirst...