Endocrine Abstracts

Somatotropin (GH) and IGF1 realise their influence on the system of intracellular metabolism and a number of important biochemical lymphocytes reactions through the receptor apparatus. It is allows to use the peripheral blood lymphocytes as the investigations object of intracellular metabolism disorders in acromegaly.Aim: To study the NAD- and NADP-dependent dehydrogenases activity in blood lymphocytes in active acromegaly patients.<p class="abstext"...

The routine approach to evaluating the effectiveness of diabetes treatment based on the level of glycated hemoglobin (HbA1c) accounts for the average glucose level but does not consider its fluctuations. However, recent data indicate that the development of late complications of diabetes is associated with the degree of variability in glycemia. (GV).Clinical case: Patient F. is 54-year-old woman with a 33-year history of type 1 diabetes with multiple chr...

Introduction: Graves’ disease (GD) is organ-specific autoimmune-inflammatory disorder characterized by a complex pathogenesis. The inflammatory process is dominated by an imbalance of the antioxidant-oxidant mechanism, increased production of reactive oxygen species (ROS), which can potentiate the cytotoxicity of neutrophils and sustain the autoimmune process and perpetuate the disease. Aim: to study the level of ROS synthesis by peripheral blood neutrophils in patients w...

Background: Oxidative stress is involved in the pathogenesis of Graves hyperthyroidism (GH) and a disbalance of the cell redox state is associated with thyroid hyperfunction and the reccurence of the disease. Aim: To study the level of reactive oxygen species (ROS) and NAD(P)-dependent dehydrogenases of peripheral blood neutrophils in patients with compensated and relapse GH ongoing thiamazole. Materials and Methods: The study incl...

Background: Increased production of reactive oxygen species (ROS) and oxidative stress play a significant role in the initiation and persistence of the autoimmune process in Graves’ disease (GD)Aim: To study the ROS level of peripheral blood monocytes in patients with GD after radioactive iodine (RAI). Materials and Methods: The study included 48 patients with a confirmed diagnosis of GD, from 18 to 65 years (mean 46.42 &pm; 1...

Graves’ disease (GD) is an autoimmune disease with genetic predisposition. The link with the major histocompatibility complex determines the complexity of the excess thyroid hormones molecular action on immune system that may cause the divergence of autoimmune process in GD, functioning not only in peripheral immune cells, but also in the thyroid. Objective: to study the phenotypic composition of T- and B-lymphocyte subset patterns in peripheral blood and thyroid tissue i...

It is known that thyroid peroxidase is expressed on the apical surface of thyrocytes, where catalyze the iodination of thyroglobulin and may, also, be a surface-cell antigen, which involves in the complement-dependent cytotoxicity reactions. Objective: to study the immune status indicies depending on thyroid peroxidase (anti-TPO) antibodies in patients with Graves’ disease (GD). Materials and methods. The study included 35 women aged from 18 to 55 years, mean age of 39.1&...

The cellular structures lipid peroxidation related to immune system dysfunction seems to have a key role in autoimmune theory of Graves’ disease (GD). Aim: to investigate chemiluminescent (CL) activity of blood neutrophilic granulocytes in patients with GD. Materials and methods: Twenty six women, mean age 40.7±13.2, with manifestation of GD up to antithyroid therapy and 30 sex- and age-matched healthy subjects were examined. Serum thyroid hormone concentrations were...

Background: Thyroid hormones participate in maturation, differentiation and triggering of immunity, but little is known about the modulating role of thyroid hormones on intracellular enzymatic reactions of immune cells and their role in immunopathogenesis of Graves’ disease (GD).Methods: The activity of NAD(P)-dependent dehydrogenases in lymphocytes and neutrophils ofperipheral blood was studied in a group of 145 women with GD, 53 (36.5%) pati...

Graves’ disease (GD) has been recognised for more than 100 years, its pathophysiological mechanisms are incompletely understood.Aim: To investigate the helper- (Th-cells) and regulatory T-cells (Treg) influence on B-lymphocytes phenotypic composition of blood and thyroid tissue in GD.Materials and methods: The study included 43 women with GD, mean age 39.95±14.38, who were performed the epifascial thyroidectomy and 67 hea...