Endocrine Abstracts

Objective: The incidence of acute pancreatitis (AP) is rising with increased prevalence of obesity, which exacerbates pancreatic injury. Metabolic syndrome (MS) is defined as a cluster condition of cardiovascular risk factors, including hyperglycaemia, dyslipidaemia, hypertension, and central obesity. We analysed if the presence of obesity and/or MS affects the course of pancreatitis.Methods: Data were collected from 140 patients with AP between January ...

Introduction: Autism is a neurodevelopmental disorder with a pathogenesis that is not completely understood. Although a genetic origin has been recognized, a potential role for environmental factors, immune dysfunctions, and variations of hormonal levels was suggested. Ghrelin is a peptide hormone which can stimulate growth hormone (GH) release by activating GH secretagogue receptor. In addition, ghrelin exerts neuroprotective effects, inhibits apoptosis in hypothalamic neuron...

A 46-year-old lady with background of type 2 DM with severe insulin resistance, hemochromatosis, bipolar disorder, glaucoma, diabetic neuropathy, hypertension, GERD, necrobiosis lipoidica, PCOS and hypercholesterolemia is followed up in complex type 2 diabetes clinic for severe insulin resistance. Her BMI is 25.7, she has freestyle libre with blood glucose readings around 15mmol/l85% of the time. HbA1c 111 on June 2022, she is on humalog 265units 7 times/day and 285units at be...

Long-term diabetes is associated with accelerated ageing of the brain as evidence by impairment of cognitive function as well as motor performance. The aim of this study was to investigate the effects of voluntary daily exercise and environmental enrichment on spatial memory and learning as well as motor coordination and learning, in diabetic mice. Briefly, BALB/C mice (20–25 g) received 55 mg/kg streptozotocin i.p. daily for 5 days. Diabetes was confirmed by measurement ...

Introduction: Adrenocortical carcioma, is an aggressive cancer originating in the cortex of the adrenal gland. Adrenocortical carcinoma is a rare tumor, in United State <25 new cases of adrenocortical tumours (benign and malignant) are diagnosed annually (0.1–0.4 cases/million per year) and malignant adrenal tumours comprise ~1% of all carcinomas diagnosed prior to 20 years of age. Adrenocortical carcinoma has a bimodal distribution by age, with cases clustering in ch...

IntroductionIn last two decades, new technological advances have permitted the use of novel approaches to the management of diabetes. Continuous Glucose Monitoring (CGM) has been linked to improved HbA1c and overall quality of life. The evidence, however, is limited to retrospective studies. This audit was designed to evaluate the effectiveness and impact of CGM before and after on HbA1c and quality of life in clinical practice setting during pandemic in...

Gonadotropin-releasing hormone (GnRH) is the master hormone regulating the reproductive axis and its pulsatile secretion is crucial for puberty onset and fertility. Disruption in GnRH neuron development or hypothalamic function can lead to absent or delayed puberty (DP), with a phenotypic spectrum from severe DP to partial or complete Hypogonadotropic Hypogonadism (HH). We aimed to identify novel genetic etiology of severe DP by screening and identifying variants in associated...

Self-limited delayed puberty (SLDP) is characterized by an onset of puberty that is more than 2-2.5 standard deviations later than the population mean age and is often familial with strong genetic determinants. The reproductive axis is regulated by gonadotropin-releasing hormone (GnRH), which plays a crucial role in initiating puberty and maintaining fertility through its pulsatile secretion. Disruption in GnRH neuron development or hypothalamic function can lead to delayed pu...

Introduction: Adrenal tumors are commonly discovered incidentally on cross-sectional abdominal imaging. The Incidence of adrenal tumors increased 10-fold in the past 2 decades, with most diagnosed in older adults. In any patient with a newly discovered adrenal mass, determining whether it is functioning adenoma or non-functioning and identifying whether it is ACTH dependent or not is crucial to avoid missing the real underlying pathology.Clinical case: A...

Introduction: Normal thyroid function is necessary for normal body function. During pregnancy if the thyroid hormone deficiency, it will induce maternal and fetal hypothyroxinemia. And the vulnerable fetuses and neonates will suffer from irreversible deficit in the neuro-psycointellectual development including mental retardation. It is being established that albumin level decreases during pregnancy with recorded increase in urine microalbumin, An elevation in both thyroid stim...