Searchable abstracts of presentations at key conferences in endocrinology

ea0081p611 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Influence of dopamine receptor d2 and dopamine transporter polymorphisms in angiopathy in patients with type 2 diabetes mellitus

Neves Marta , Santos Ana Carolina , Ferreira Joana , Raposo Joao F. , Valente Ana , Bicho Manuel

Introduction and Aim: Dopamine receptor D2 (DRD2) polymorphism (rs1800497) appears to be associated with increased susceptibility to the development of type 2 diabetes mellitus (T2DM). The dopamine transporter (DAT) determines dopamine signalling, responsible for the reuptake of its active form from the synapse. Polymorphism in the DAT gene (rs2836317) can increase dopamine reuptake in the synaptic cleft. However, its association with T2DM is still controversial.<p class="...

ea0049ep562 | Diabetes complications | ECE2017

Biomarkers status and their relation with the presence of type 2 diabetes with and without angiopathy

Valente Ana , Bicho Manuel , Duarte Rui , Raposo Joao , Costa Helena Soares

Introduction: A useful tool for disease clinical characterization and treatment of type 2 diabetes is the knowledge on the status of several biomarkers. The aim of this study was to evaluate the levels of cardiovascular, oxidative stress and nutritional biomarkers and their relationship with the presence of type 2 diabetes and angiopathy.Methods: A population-based case-control study in 150 Portuguese type 2 diabetic patients was performed. Group I &#150...

ea0037ep538 | Diabetes (complications &amp; therapy) | ECE2015

Contribution of haptoglobin and MTHFR polymorphisms to hyperhomocysteinemia and hypercysteinemia in type 2 diabetic patients

Valente Ana , Bicho Manuel , Garcia Ana , Goncalves Conceicao , Duarte Rui , Raposo Joao F , Costa Helena S

Introduction: There is a lack of epidemiological data on the distribution of haptoglobin and C677T of MTHFR polymorphisms in Caucasians type 2 diabetic patients. The contribution of these two genetic factors to hyperhomocysteinemia and hypercysteinemia can be useful to prevent cardiovascular events and to reduce public health costs. The aim of this study is to evaluate the contribution of haptoglobin and C677T polymorphisms for hyperhomocysteinemia and hypercysteinemia in Port...

ea0073aep228 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Association of IDO polymorphism with oxidative status, metabolic control and inflammation in patients with type 2 diabetes mellitus

Neves Marta , Bicho Manuel , Santos Ana Carolina , João F. Raposo , Valente Ana

IntroductionThe Indoleamine 2.3-dioxygenase (IDO) is an enzyme involved in tryptophan metabolism, encoded by the IDO1 gene in humans. In Caucasians, the rs9657182 polymorphism of IDO gene was found to be associated with neurobehavioral complications, especially depression. Several studies in Type 2 Diabetes Mellitus (T2DM) describe psychological factors as barriers to the successful implementation of a healthy eating plan. According to our knowledge ther...

ea0049oc5.4 | Cardiovascular Endocrinology | ECE2017

Food history characterization of Portuguese centenarians, nutritional biomarkers and cardiovascular risk: case control study

da Silva Alda Pereira , Chaves Catarina , Matos Andreia , Gil Angela , Santos Carolina , Valente Ana , Bicho Manuel , Clara Joao Gorjao

Introduction: Eating habits may contribute to longevity. Consumption of red meat, source of saturated fatty acids and cholesterol may be associated with increased risks of diabetes, cardiovascular disease (CVD), and mortality risk.Methods: We studied 521 subjects, both genders, 253 centenarians (CENT) (100.26±1.98 age) and 268 controls (67.51±3.25 age), both low (LCR) and high cardiovascular risk (HCR), calculated based on QRISK®2-2016. An...

ea0037ep113 | Steroids, development and paediatric endocrinology | ECE2015

Sarcopenia, more that dehydration, may be associate to underweight Portuguese centenarians

Silva Alda Pereira da , Matos Andreia , Valente Ana , Gil Angela , Alonso Isanete , Ribeiro Ricardo , Clara Gorjao , Bicho Manuel

Introduction: Fat-free mass has a functional significance in aging. The objective of this study was to evaluate the prevalence of underweight in a Portuguese population of centenarians and their relationship with dehydration or sarcopenia.Methods/design: Anthropometric data were obtained using standard procedures from 252 centenarians (100.26±1.99 years), 77.8% women (W). Body composition was assessed by tetrapolar bioimpedance. It was considered de...

ea0056p473 | Diabetes complications | ECE2018

The effect of glutathione S-transferase M1 and T1 polymorphisms on ascorbic acid plasma levels in diabetic patients

Valente Ana , Bicho Manuel , Carolina Santos Ana , Matos Andreia , Duarte Rui , Raposo Joao F , Costa Helena S

Introduction: Type 2 diabetes mellitus have been associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress. Meta-analyses have indicated that deletion of either GSTM1 or GSTT1 is associated with a significant increased risk of coronary heart disease. The aim of this study was to evaluated if ascorbic acid (AA) plasma levels differ by GST genotype in d...