Endocrine Abstracts

Key4OI : Development and implementation of a Standard set of Outcome measures for Osteogenesis Imperfecta. Osteogenesis Imperfecta (OI) is a genetic disorder also known as ‘brittle bone disease’. The clinical manifestation of OI shows a wide variation. Therefore, care for patients with OI requires an interdisciplinary approach. The effectiveness of particular interventions and treatment protocols of interdisciplinary teams is not clear due to a non-standardized and w...

Determination of radiochemical purity (RCP) of radiopharmaceuticals based on 68Ga-BCA-peptides (68Ga-DOTA-TOC/-TATE, 68Ga-NODAGA-RGD2, 68Ga-PSMA-HBED-CC, etc.) is an extremely important part of QC in routine clinical practice. Nature of gallium leads to formation of two major radiochemical impurities in the radiopharmaceutical: hydrolyzed 68Ga (colloid) and unbounded ionic forms of 68Ga. The amounts o...

Cushing’s tumours are ACTH-producing neoplasms of the pituitary gland. Their ACTH-oversecretion is autonomous and does not respond to the canonical inhibition of the hence also elevated cortisol. Current research in identifying new drug targets is mainly focused on designing therapeuticals that directly inhibit ACTH over-secretion from the adenoma. Serum and glucocorticoid-induced kinase 1 (Sgk1) is an early target gene of glucocorticoids in all cells studied. It is a PKB...

In 2015 AdrenalNET organized a roundtable conference with patient representatives, prescribers and pharmaceutical industry. The cause of this meeting was complaints of patients about the problematic hydrocortisone market in the Netherlands, characterized by frequent availability issues (shortage ) of the hydrocortison tablets/capsules and frequent changes in manufacturers (compounding companies) leading to quality issues. All parties at the roundtable meeting agreed to join fo...

Background: It is known that rheumatoid arthritis (RA) can be a part of autoimmune polyglandular syndrome and be combined with endocrine diseases.Objectives: To study the effects of autoimmune thyroiditis (AIT) and diabetes mellitus (DM) on the clinical and laboratory manifestations of RA.Methods: The study included two groups of patients. The first group of patients included 24 patients (20 women and 4 men, mean age - 68.37±1...

Background: The prescription of triiodothyronine (T3) for hypothyroidism is increasing worldwide, however, long-term effects of its use are largely unknown. Previous studies have suggested possible association between T3 use and breast cancer. The aim of the study was to examine the effects of T3 use on cancer incidence and mortality.Material: Our sample included the full adult population of individuals living in Sweden with at least three purchases of t...

Background: Development of thyroid ultrasound and FNA is more frecuent to make it in a endocrine clinic, that means to make more diagnosis medical process and so to avoid more outpatients visits. But it’s neccesary a specific treaning. We tried to evaluated our treaning.Material and methods: After specific treating in radiologic department, we have compared our results in two consecutive periods. The first one in the first year after treaning develo...

There is an accumulating amount of evidence that the metabolic adaptations to endurance exercise that result in increased intramuscular triglyceride (IMTG) stores and IMTG oxidation during exercise, also exert a protective effect on muscle insulin sensitivity. This seems to be a contradiction (known as the athlete's paradox) as large IMTG stores in sedentary and obese individuals coexist with high levels of fatty acid (FA) metabolites (specifically long-chain acylCoA, DAG and ...

Glucocorticoids act directly on pancreatic islets suppressing insulin secretion from the beta cells through a genomic mechanism of slow onset. We present here data on immediate actions of dexamethasone on two models of insulin secretion: RINm5F and INS-1 beta cell lines. Under normal glucose concentrations, dexamethasone rapidly (within minutes) decreased insulin secretion about 30%. Under hypoglycaemic conditions (glucose reduced to 50% for 1 hour) dexamethasone increased ins...

Background: Osteogenesis Imperfecta (OI) is commonly defined as ‘brittle bones’ disease, but there are also more characteristics like blue sclerae, hearing loss, dental problems, ligamentous laxity and a short stature. Easy bruising is also a very common feature and there are multiple case reports on haemorrhagic events in OI. Larger population studies on bleeding tendency in OI are very sparse, while other connective tissue disorders with easy bruising have much mor...