Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep749 | Pituitary and Neuroendocrinology | ECE2023

A case of Turner syndrome associated with growth hormone deficiency

Serban Cristina , Baculescu Nicoleta , Poiana Catalina

Background: Turner syndrome (TS) is an important cause of short stature, however, there are a few reported cases of concomitant occurrence of TS and growth hormone deficiency (GHD).Case report: We report a 23-year-old female with concominat TS and GHD, also presenting partial FSH/LH deficiency and primary myxedema. The patient had iniatially been evaluated at the age of 15 for short stature and primary amenorrhea when she was diagnosed with Turner syndro...

ea0099ep984 | Calcium and Bone | ECE2024

Recurrent hyperparathyroidism after total parathyroidectomy with autotransplantation in a patient with long-term hemodialysis

Serban Cristina , Baculescu Nicoleta , Poiana Catalina

Background: Recurrenthyperparathyroidism following total parathyroidectomy with autotransplantation in patients with end-stage renal disease who are on hemodialysis is not an uncommon condition and can be due to hyperplastic autografted tissue, remnant parathyroid tissues in the neck or in the presence of ectopic and/or supernumerary parathyroid glands.Case report: We report the case of a 66-year-old patient with a history of chronic kidney disease on he...

ea0063p1062 | Pituitary and Neuroendocrinology 3 | ECE2019

Osteitis fibrosa cystica of the skull in a patient with primary hyperparathyroidism

Biban Georgiana Bianca , Baleanu Maria , Baculescu Nicoleta , Smarandache Romeo Marian , Corneci Cristina , Hortopan Dan , Poiana Catalina

Background: Overt parathyroid bone disease is a rare entity. We present a case of primary hyperparathyroidism (PHPT) and osteitis fibrosa cystica with involvement of multiple facial bones and neurocranium. Although the initial differential diagnosis was between acromegaly and bone malignancy, endocrine assessment demonstrated PHPT, with favorable outcome after parathyroidectomy.Case report: A 59-year-old woman referred to our clinic with painful swelling...

ea0032p594 | Female reproduction | ECE2013

PCOS subphenotypes stratification reveals an apparent increase of metabolic syndrome frequency in patients with concomitant hyperandrogenism and menstrual irregularities

Baculescu Nicoleta , Radian Serban , Gussi Ilinca , Gheorghiu Monica , Poiana Catalina , Grigorescu Florin , Coculescu Mihail

Background: PCOS-associated increased metabolic risk may be selective, owing to its heterogeneous nature. Identification of high-risk individuals could enable better studies and prevention of complications.Aim: To characterize the metabolic risk, as metabolic syndrome (MetS), of specific PCOS subphenotypes.Subjects and methods: Romanian PCOS (Rotterdam criteria) and 64 controls, 18–35 years. PCOS subphenotypes were defined: i)...

ea0022p498 | Female reproduction | ECE2010

CAG repeat alleles of the androgen receptor are associated with polycystic ovary syndrome (PCOS) in the Romanian population

Radian Serban , Baculescu Nicoleta , Aflorei Daniela , Gussi Ilinca , Vladoiu Suzana , Ianas Olga , Grigorescu Florin , Coculescu Mihai

Background: Androgen receptor (AR) activity is modulated by the length of CAG-repeat polymorphism in exon 1. Published data suggest association between CAG-repeat alleles and PCOS, but not all studies confirmed this finding.Aim: To test association of AR alleles with PCOS and clinical and biochemical signs of hyperandrogenism.Study design: Case–control association study, approved by the institutional ethical committee, of 137 ...

ea0081ep882 | Reproductive and Developmental Endocrinology | ECE2022

Anti-müllerian hormone analysis as a predictor of the polycystic ovary syndrome diagnosis in romanian women

Baculescu Nicoleta , Leonte Laura , Radian Serban , Gheorghiu Monica , Caragheorgheopol Andra , Biban Bianca , Serban Cristina , Grigorescu Florin , Poiana Catalina

Background: Higher anti-Müllerian hormone (AMH) values are associated with polycystic ovary syndrome (PCOS) and AMH is proposed as a marker of PCOS, however, the optimal diagnostic threshold is not yet defined.Aim: To study the significant correlations of AMH in PCOS and the accuracy and threshold of AMH for the PCOS diagnosis in Romania.Subjects and methods: Serum AMH, TT, LH, FSH, fasting glucose and insulin (Ins), HOMA-IR a...

ea0063p1133 | Reproductive Endocrinology 2 | ECE2019

Serum anti-Müllerian hormone is significantly associated with higher luteinizing hormone level in polycystic ovary syndrome

Baculescu Nicoleta , Leonte Laura , Radian Serban , Gheorghiu Monica , Muresan Andrei , Biban Bianca , Baleanu Maria , Grigorescu Florin , Poiana Catalina

Background: Recent data highlight the role of anti-Müllerian hormone (AMH) to trigger the neuroendocrine abnormalities involving GnRH and secretion of gonadotropins in polycystic ovary syndrome (PCOS).Aim: To study factors significantly correlated with neuroendocrine dysfunction in PCOS, with focus on AMH.Subjects and methods: We performed a cross-sectional study in 137 patients with PCOS selected by Rotterdam 2003 criteria an...

ea0049gp137 | Female Reproduction | ECE2017

Genetic susceptibility for adrenal hyperandrogenism in polycystic ovary syndrome

Baculescu Nicoleta , Haydar Sarah , Gheorghiu Monica Livia , Radian Serban , Lautier Corinne , Poiana Catalina , Pugeat Michel , Grigorescu Florin

Background: Hyperandrogenism is a main feature of the polycystic ovary syndrome (PCOS). Although its ovarian origin is well recognized, laboratory investigation suggested the contribution of adrenal gland, albeit of unknown mechanism.Aim: To understand the contribution of genetic factors in adrenal hyperandrogenism (AH) we investigated genome wide SNPs in subgroups of PCOS patients stratified as function of DHEAS levels in two ethnic populations (Romania...

ea0025p282 | Reproduction | SFEBES2011

Case–control study of 5-alpha reductase type 2 Val89Leu polymorphism in Romanian PCOS patients

Radian Serban , Radulescu Cristina Ramona , Aflorei Daniela , Gheorghiu Monica , Baculescu Nicoleta , Albu Alice , Fica Simona , Grigorescu Florin , Coculescu Mihail

Background: Hyperandrogenism (HA) is required for diagnosis of polycystic ovary syndrome (PCOS) and it is central to PCOS pathogenesis. Putative mechanisms of hyperandrogenism include disregulation of steroidogenesis, plasma transport and peripheral tissue regulation. Therefore, 5-alpha reductase genes (SRD5A1, SRD5A2), that regulate peripheral tissue conversion of testosterone to more potent dihydrotestosterone are good PCOS candidate genes. The single published study of SRD5...

ea0020p490 | Obesity and Metabolism | ECE2009

Insulin-resistance and abnormal glycaemia characterize the metabolic syndrome of polycystic ovary syndrome but not of matched controls

Radian Serban , Mihaila Valentina Raluca , Botusan Ileana , Baculescu Nicoleta , Gheorghiu Monica , Fica Simona , Grigorescu Florin , Coculescu Mihail

Background: The incidence of metabolic syndrome (MetS) is higher in polycystic ovary syndrome (PCOS) patients than in the general population. However, it is still unclear if MetS is qualitatively different in PCOS.Aim: To compare the distribution of MetS diagnostic criteria and of insulin-resistance in subjects with MetS (PCOS versus matched controls).Patients: Of 97 patients with PCOS (Rotterdam criteria) and 31 age- and BMI-match...