Endocrine Abstracts

Introduction: Somatostatin analogues (SSA) have been used as first line treatment to control the symtoms in hormonally active neuroendocrine tumors (NET), for over three decades. Primary hepatic neuroendocrine tumors (PHNETs) are rare neoplasms. Despite increased incidence of PHNETs over time, these tumors remain a rarity. According to the previously reported cases, primary neuroendocrine carcinoma of the liver is usually multicentric, often mimicking liver metastases. The dem...

The cardiovascular system (CVS) is one of the major targets of thyroid hormone action.The thyroid function has a direct effect on heart rate, cardiac output and systemic vascular resistance.The prevalence of hypothyroidism in the general population is high, particularly in females (9–15%). Overt hypothyroidism is associated with severe cardiovascular manifestations including reduced intravascular volume, increased systemic vas...

The study evaluates the expression of same immunohistochemical (IHC) markers (Ki-67, PCNA, CK-19, HBME-1 and Galectin 3, in the diagnosis of differentiated thyroid carcinomas.Material and methods: The study group comprised 57 patients with thyroid tumors; aged 17–71 years (mean age 48.96 years). All cases were evaluated before surgical treatment by means of clinical examination, thyroid ultrasonography and fine needle aspiration biopsy (FNAB).<p...

This study represents a complex evaluation of a group of 26 cases with thyroid nodular disease (TND), using different diagnostic methods. Clinically and by means of ultrasonography, 12 patients were suspected of malignancy. Fine-needle aspiration biopsy (FNAB) detected mainly suspicious (12 cases) and malignant smears (5 cases). The microscopic examination of surgical specimens established the following diagnosis: follicular adenoma – FA (4 cases), papillary hyperplasia &...

Introduction: Differentiated thyroid cancer is one of the most common endocrine malignancies. The most common thyroid cancer in adolescence is PTC. It presents with a high rate of loco regional ganglionic metastasis. Hodgkin lymphoma (HL) is a heterogeneous group of neoplasms with an incidence, in Europe, estimated around 2.2–2.7 per 100 000 cases per year. In front of each adolescent case, with concomitant thyroid and lymph nodes, the main question that arises is the pre...

Introduction: CD56 (neural cell adhesion molecule/NKH1/LEU19 and LEU7/NHK-1) is an antigen related to follicular epithelium differentiation.Materials and methods: We evaluated the expression of CD56 protein in normal follicular thyroid tissue, 15 non-neoplastic thyroid lesions (nodular hyperplasia–NH, Graves–Basedow disease (GB) and chronic lymphocytic/Hashimoto is thyroiditis (HT) and 38 thyroid neoplasias derived from follicular cells (25 PTC...

Background: Acromegaly is a chronic rare disease induced by persistent hypersecretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in adult patients. Several studies have associated acromegaly with an increased risk for developing different benign or malignant tumors.Case presentation: A 33-year old female patient was diagnosed with acromegaly due to a large pituitary macroadenoma, in 2009. In the same period, she was also diagnosed wi...

Background: Whereas many papers have reported on clinical and morpho pathological features of thyroid cancer with BRAFV600E mutation, a limited number of studies have been focused on the quantification of BRAF mRNA expression in thyroid tumors.The present study aimed to assess the expression of BRAF transcript in fine needle aspiration specimens, prelevated from cases with nodular thyroid disease.Material and methods: Th...

Introduction: Thyroid follicular adenomas (FA) and adenomatous nodules (AN) – lesions frequently found in areas with iodine deficiency, can be normo-/hypofunctioning (scintigraphically cold – SCN) or hyperfunctioning (scintigraphically hot – SHN) nodules.Aim: Evaluation of proliferation potential in thyroid nodules on tissue samples obtained at surgery from euthyroid patients clinically diagnosed with SCN and from patients with thyroid hyp...

Introduction: Cytokeratin-19 (CK19), p53 and Ki-67 are some of the proposed markers for differentiating benign from malignant thyroid tumors.Material and method: We evaluated the tissue expression of the three markers in 60 thyroid lesions including: 8 cases of nodular hyperplasia (NH), 16 follicular adenomas (FA), 26 papillary carcinomas (PC) and 10 follicular carcinomas (FC). Tissue sections fixed in formalin and embedded in paraffin were immunohistoch...