Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep153 | Endocrine tumours and neoplasia | ECE2017

Primary hepatic neuroendocrine tumor with multiple liver metastases treated with somatostatin analogues: case report

Golu Ioana , Balas Melania , Amzar Daniela , Cornianu Marioara , Vlad Mihaela

Introduction: Somatostatin analogues (SSA) have been used as first line treatment to control the symtoms in hormonally active neuroendocrine tumors (NET), for over three decades. Primary hepatic neuroendocrine tumors (PHNETs) are rare neoplasms. Despite increased incidence of PHNETs over time, these tumors remain a rarity. According to the previously reported cases, primary neuroendocrine carcinoma of the liver is usually multicentric, often mimicking liver metastases. The dem...

ea0032p1047 | Thyroid (non-cancer) | ECE2013

Clinical and subclinical hypothyroidism and their relation to cardiovascular risk factors

Golu Ioana , Vlad Mihaela , Cornianu Marioara , Amzar Dana , Tudoran Cristina

The cardiovascular system (CVS) is one of the major targets of thyroid hormone action.The thyroid function has a direct effect on heart rate, cardiac output and systemic vascular resistance.The prevalence of hypothyroidism in the general population is high, particularly in females (9–15%). Overt hypothyroidism is associated with severe cardiovascular manifestations including reduced intravascular volume, increased systemic vas...

ea0016p751 | Thyroid | ECE2008

Same aspects regarding immunohistochemical diagnosis of papillary thyroid carcinoma

Zosin Ioana , Golu Ioana , Cornianu Marioara , Amzar Daniela , Balas Melania

The study evaluates the expression of same immunohistochemical (IHC) markers (Ki-67, PCNA, CK-19, HBME-1 and Galectin 3, in the diagnosis of differentiated thyroid carcinomas.Material and methods: The study group comprised 57 patients with thyroid tumors; aged 17–71 years (mean age 48.96 years). All cases were evaluated before surgical treatment by means of clinical examination, thyroid ultrasonography and fine needle aspiration biopsy (FNAB).<p...

ea0014p335 | (1) | ECE2007

Usefulness of Ki-67, PCNA, c-erbB-2 and CK 19 in the diagnosis of some thyroid follicular tumors

Zosin Ioana , Cornianu Marioara , Golu Ioana , Balas Melania , Milos Aurora

This study represents a complex evaluation of a group of 26 cases with thyroid nodular disease (TND), using different diagnostic methods. Clinically and by means of ultrasonography, 12 patients were suspected of malignancy. Fine-needle aspiration biopsy (FNAB) detected mainly suspicious (12 cases) and malignant smears (5 cases). The microscopic examination of surgical specimens established the following diagnosis: follicular adenoma – FA (4 cases), papillary hyperplasia &...

ea0067gp9 | Poster Presentations | EYES2019

Papillary thyroid carcinoma and Hodgkin Lymphoma in young patients – case report

Cotoi Laura , Borlea Andreea , Petrescu Carmen , Jinca Crtistian , Cerbu Simona , Varcus Flore , Cornianu Marioara , Stoian Dana

Introduction: Differentiated thyroid cancer is one of the most common endocrine malignancies. The most common thyroid cancer in adolescence is PTC. It presents with a high rate of loco regional ganglionic metastasis. Hodgkin lymphoma (HL) is a heterogeneous group of neoplasms with an incidence, in Europe, estimated around 2.2–2.7 per 100 000 cases per year. In front of each adolescent case, with concomitant thyroid and lymph nodes, the main question that arises is the pre...

ea0035p573 | Endocrine tumours and neoplasia | ECE2014

CD56 immunohistochemical expression: a useful tool for the diagnosis of in thyroid carcinomas of follicular origin

Cornianu Marioara , Golu Ioana , Amzar Daniela , Taban Sorina , Muresan Anca , Dema Alis

Introduction: CD56 (neural cell adhesion molecule/NKH1/LEU19 and LEU7/NHK-1) is an antigen related to follicular epithelium differentiation.Materials and methods: We evaluated the expression of CD56 protein in normal follicular thyroid tissue, 15 non-neoplastic thyroid lesions (nodular hyperplasia–NH, Graves–Basedow disease (GB) and chronic lymphocytic/Hashimoto is thyroiditis (HT) and 38 thyroid neoplasias derived from follicular cells (25 PTC...

ea0070ep514 | Thyroid | ECE2020

Management and evolution of papillary thyroid carcinoma in a patient with acromegaly

Vlad Mihaela , Cornianu Marioara , Balas Melania , Golu Ioana , Amzar Daniela-Georgiana , Varcus Flore

Background: Acromegaly is a chronic rare disease induced by persistent hypersecretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in adult patients. Several studies have associated acromegaly with an increased risk for developing different benign or malignant tumors.Case presentation: A 33-year old female patient was diagnosed with acromegaly due to a large pituitary macroadenoma, in 2009. In the same period, she was also diagnosed wi...

ea0026p65 | Endocrine tumours and neoplasia | ECE2011

Significance of BRAF expression in nodular thyroid disease: prognostic and therapeutic implications

Golu Ioana , Neghina Adriana , Cornianu Marioara , Amzar Daniela , Balas Melania , David Dana , Vlad Mihaela

Background: Whereas many papers have reported on clinical and morpho pathological features of thyroid cancer with BRAFV600E mutation, a limited number of studies have been focused on the quantification of BRAF mRNA expression in thyroid tumors.The present study aimed to assess the expression of BRAF transcript in fine needle aspiration specimens, prelevated from cases with nodular thyroid disease.Material and methods: Th...

ea0026p428 | Thyroid (non cancer) | ECE2011

Proliferative potential of normo- and hyperfunctioning thyroid nodules

Cornianu Marioara , Dema Alis , Golu Ioana , Taban Sorina , Vlad Mihaela , Lazar Elena , Lazureanu Codruta , Grigoras Mirela

Introduction: Thyroid follicular adenomas (FA) and adenomatous nodules (AN) – lesions frequently found in areas with iodine deficiency, can be normo-/hypofunctioning (scintigraphically cold – SCN) or hyperfunctioning (scintigraphically hot – SHN) nodules.Aim: Evaluation of proliferation potential in thyroid nodules on tissue samples obtained at surgery from euthyroid patients clinically diagnosed with SCN and from patients with thyroid hyp...

ea0026p481 | Thyroid cancer | ECE2011

The value of CK19, Ki-67 and p53 expression in the diagnosis of thyroid follicular neoplasms

Cornianu Marioara , Dema Alis , Taban Sorina , Golu Ioana , Muresan Anca , Cornea Remus , Lazar Elena , Faur Alexandra

Introduction: Cytokeratin-19 (CK19), p53 and Ki-67 are some of the proposed markers for differentiating benign from malignant thyroid tumors.Material and method: We evaluated the tissue expression of the three markers in 60 thyroid lesions including: 8 cases of nodular hyperplasia (NH), 16 follicular adenomas (FA), 26 papillary carcinomas (PC) and 10 follicular carcinomas (FC). Tissue sections fixed in formalin and embedded in paraffin were immunohistoch...