Searchable abstracts of presentations at key conferences in endocrinology

ea0084ps1-02-13 | Hypothyroidism | ETA2022

Sex hormones levels and chronic autoimmune thyroiditis in a cohort of obese male patients

Sagnella Alfonso , Ciuoli Cristina , Bufano Annalisa , Benenati Nicoletta , Fralassi Noemi , Cartocci Alessandra , Grazia Castagna Maria

Introduction and Aim: Obesity is associated with an increased risk of hypothyroidism and chronic autoimmune thyroiditis (AIT). However, little is known about the underlying pathogenic mechanisms. Recently it has been evaluated the role played by sex hormones in the onset of AIT and, analysing the data from a large cohort of normal/overweight males, a positive correlation between an increased ratio of estradiol/testosterone levels (E2/T) and AIT was found. Since obese males are...

ea0084ps1-03-26 | Thyroid Cancer CLINICAL 1 | ETA2022

Age as a prognostic factor in ata low and intermediate risk thyroid cancer patients

Maino Fabio , Botte Monica , Valerio Laura , Cartocci Alessandra , Grazia Castagna Maria

Background and Aim: American Thyroid Association (ATA) guidelines do not consider age at diagnosis of differentiated thyroid cancer (DTC) as a prognostic factor in the estimation of risk of recurrence and persistent disease. While age at diagnosis has already been assessed in high-risk patients, it remains to be established whether there is a correlation between age at diagnosis and long term outcome in DTC patients.Methods: We retrospectively evaluated ...

ea0092op-10-02 | Oral Session 10: Novel diagnostics in Thyroid cancer | ETA2023

Role of the telomere abnormalities and chromosome fragility on the risk of second malignant tumor in papillary thyroid cancer patients

Valerio Laura , Mattii Elisa , Cantara Silvia , Cartocci Alessandra , Maino Fabio , Grazia Castagna Maria

Objectives: Genomic instability play a role in cancer development through different mechanisms including chromosome fragility and in particular the altered telomere length (TL). Previous studies showed that the presence of short telomeres in the blood was associated with development of sporadic head and neck, bladder, lung, renal and breast cancer. In thyroid cancer, has been demonstrated that familial form of papillary thyroid cancer (FPTC) has shorter telomeres in blood leuk...

ea0092ps1-04-06 | Nodules-surgery | ETA2023

Role of superb microvascular imaging in thyroid nodule risk stratification

Mattii Elisa , Maino Fabio , Trimarchi Andrea , Dalmiglio Cristina , Cartocci Alessandra , Grazia Castagna Maria

Introduction: Angiogenesis plays an important role in the growth and processes of tumors, often indicating neovascularity. However the role of vascularization in thyroid nodules observed with power or color doppler has always been debated. Therefore, most of thyroid nodules sonographic risk classification do not consider vascularization as an important features in predicting the risk of malignancy. In the last years a new vascular imaging technique, Superb Microvascular Imagin...

ea0084op-01-05 | Oral Session 1: Topic Highlights | ETA2022

Sarcopenia as a prognostic factor in patients with advanced thyroid cancer treated with tyrosine kinase inhibitors

Dalmiglio Cristina , Brilli Lucia , Ciuoli Cristina , Sannino Ida , Maino Fabio , Valerio Laura , Cartocci Alessandra , Grazia Castagna Maria

Objective: Recent studies have shown that sarcopenia at cancer diagnosis is associated with a poor survival in patients with solid tumors. Up to now, few data are available among patients with advanced thyroid cancer, especially those treated with tyrosine kinase inhibitors (TKI). We retrospectively evaluated sarcopenia by Skeletal Muscle Index (SMI) in a cohort of advanced thyroid cancer patients before and during TKI treatment and investigated its association with treatment ...

ea0084op-09-44 | Oral Session 9: Thyroid Cancer Clinical | ETA2022

Dynamic risk stratification in long-term clinical outcome of papillary thyroid cancer patients

Valerio Laura , Maino Fabio , Dalmiglio Cristina , Brilli Lucia , Botte Monica , Dalmazio Gilda , Di Stefano Leonardo , Grazia Castagna Maria

Introduction and Objective: The initial assessment of differentiated thyroid cancer (DTC) patients is based on the American Thyroid Association (ATA) risk stratification criteria. Dynamic risk stratification (DRS) of DTC patients takes into consideration the response to initial treatment being reassessed at 1–2 years and revealed significant shifts in the risk categories of DTC patients. We aimed to evaluate the long-term outcome of papillary thyroid cancer (PTC) patients...

ea0063gp193 | Adrenal and Neuroendocrine - Clinical | ECE2019

Comparison of whole-genome expression analysis in patients with secondary adrenal insufficiency treated with conventional treatment versus modified-release hydrocortisone

Pilli Tania , Cardinale Sandro , Forleo Raffaella , Cantara Silvia , Ferracin Manuela , Bassi Cristian , Negrini Massimo , Grazia Castagna Maria

Background: Conventional treatment (cortisone acetate or hydrocortisone) of adrenal insufficiency (AI) is potentially associated with glycometabolic alterations, bone loss and reduced quality of life. There is an increasing evidence of a more physiological replacement therapy with modified-release hydrocortisone (Plenadren).AimThe objectives of our study were: 1) to compare the gene expression profile of patients under conventional treatment and Plenadren versus healthy contro...

ea0092ps3-29-05 | Treatment 2 | ETA2023

Tailored mortality risk in stage I-II DTC patients by integrating ata stratification and response to initial therapy

Dalmiglio Cristina , Forleo Raffaella , Fralassi Noemi , Maino Fabio , Brilli Lucia , Valerio Laura , Trimarchi Andrea , Pilli Tania , Cartocci Alessandra , Grazia Castagna Maria

Objectives: AJCC/TNM staging system provides an estimate of mortality risk in differentiated thyroid cancer (DTC) patients and recent evidence showed that ATA risk stratification may improve the definition of this risk. We speculated that the integration of the response to the initial therapy (RIT) could better define the mortality risk.Methods: We retrospectively evaluated 891 consecutive DTC patients followed at the Section of Endocrinology, University...

ea0073aep642 | Thyroid | ECE2021

Estimating risk of recurrence of differentiated thyroid cancer patients: a real-world multicenter validation of the american thyroid association initial risk stratification and dynamic re-assessment after 5 years of follow-up.

Cera Gianluca , Grani Giorgio , Puxeddu Efisio , Arvat Emanuela , Pontecorvi Alfredo , Pio Lombardi Celestino , Torlontano Massimo , Chiara Zatelli Maria , Antonelli Alessandro , Tallini Giovanni , GRAZIA CASTAGNA MARIA , Fugazzola Laura , Filetti Sebastiano , Durante Cosimo

BackgroundMost Differentiated Thyroid Cancer (DTC) cases typically show indolent biological behavior and a low mortality rate. Various prognostic systems are used to assess disease recurrence risk, to tailor treatment and follow-up strategies. The initial Risk Stratification System (RSS) and dynamic Response to Therapy Re-stratification (RTR) system, recommended by the 2015 American Thyroid Association (ATA) Guidelines, are the most employed. Still, they...