Endocrine Abstracts

Aim: Despite multiple dose injections some patients still fail achieving HbA1c target. We aimed to evaluate the effect of sitagliptin add on therapy to multiple dose insulin injections.Method: Data of 47 (seven males and 40 females) type 2 diabetic patients who had HbA1c over 7% were retrospectively evaluated. They were already treated with premix lispro or aspart insulin (n=28), glargine plus premeal regular or aspart or lispro insulin (n</...

Aim: We aimed determinants of insulin usage in pregnant women with impaired carbohydrate metabolism (ICM).Methods: We collected 164 pregnant women in any trimester who were referred to endocrinology unit due to suspicion of ICM by obstetricians. Diagnostic laboratory criteria were as follows: fasting glucose ≥126 mg/dl in first trimester; 1 hour 50 g challenge test glucose ≥180 mg/dl; any value exceeding threshold during OGTT (...

Aim: Thyrotoxicosis is a clinical status related to increased thyroid hormones. It is caused by either hyperfunctioning thyroid tissue or destruction of thyroid. Subacute thyroiditis, also known as De Quervain or granulomatous thyroiditis, is an acute inflammatory disease of thyroid causing thyrotoxicosis. Clinical and laboratory features vary according to the course of disease. In this study, we aimed to study clinical and laboratory features of the patients who were referred...

Kearns-Sayre syndrome (KSS) is a mitochondrial disorder characterized by progressive external ophthalmoplegia, pigmentary retinopathy, together with cardiac conduction defects, muscle abnormalities and endocrinopathies such as growth hormone deficiency (GHD), diabetes and hypoparathyroidism.We present a 2 years 9 months-old boy with clinical and biochemical diagnosis of KSS and GHD. He was referred with failure-to-thrive. He was born at term from healthy...

Introduction: In children with congenital adrenal hyperplasia (CAH), central precocious puberty (CPP) may occur and this situation may compromise final height. We aimed to evaluate the effect of GnRH analog therapy (GnRHa-T) on growth in children with CAH.Design: Ten children with CAH were included in ongoing follow-up study. Nine children underwent GnRH stimulation test. GnRHa-T was used as 3.75 mg/q 4 weeks and the dose had to be increased to 7.5 mg/q ...

Aim: Low BMD and atherosclerosis may share similar underlying biological mechanisms including higher serum phosphate and inflammation. Neutrophil-lymphocyte ratio (NLR) as a simple marker of inflammation. There are scarce data indicating improved atherosclerosis and cardiovascular events with biphosphonate and teriparatide therapy. We aimed to evaluate NLR before and after 6 months of teriparatide therapy in patients with severe established osteoporosis....

Introduction: Platelets and neutrophils take part in proliferation of cancer cells, angiogenesis, and metastasis. Studies on various cancer types showed relation between prognosis and absolute numbers of neutrophils, lymphocytes, and the ratio in-between (NLR) and platelet/lymphocyte ratio (PLR). We aimed to evaluate NLR and PLR and their relation with features of differentiated thyroid carcinoma (DTC).Materials and methods: Electronic data of 330 patien...

Atherosclerosis is the major cause of death in type 2 DM. Increased intima media thickness (IMT) denotes subclinical atherosclerosis. Endothelial cells express GLP-1 receptors. There are a few studies regarding the effect of GLP-1 system modifying agents on IMT. Although most of them indicates decreased IMT, the results are contradictory.We aimed to compare the effect of sitagliptin, vildagliptin, and exenatide on IMT measurement in type 2 DM.<p clas...

Background: Suture granuloma, the rare complication of thyroidectomy, results from use of nonabsorbable suture materials. Despite its typical ultrasound images and benign course, it carries utmost importance in differential diagnosis of lymph nodes, recurrent nodules, and recurrence in case of thyroid cancers.Case report: A 54-year-old female patient, who underwent bilateral thyroidectomy in July 2010, was diagnosed with multinodular goiter and incidenta...

Introduction: Graves’ disease and Hashimoto’s hypothyroidism are common thyroid diseases. However, occurrence of both clinical disorders one after the other in the same patient, is not common.Case report: In this article, we presented two hypothyroid patients who developed clinical thyrotoxicosis during levothyroxine treatment. Both patients were treated with levothyroxine for a long time. Due to occurrence of clinical hyperthyroidism, levothyr...