Endocrine Abstracts

Introduction: Pseudoxanthoma elasticum (PXE), a multisystem heritable disorder, is characterized by ectopic mineralization of soft connective tissues. It is an autosomal recessive disorder in which mutations in the ABCC6 gene result in low levels of inorganic pyrophosphate (PPi).In its classic form, PXE is a late-onset, slowly progressing disease, and the major clinical problems relate to development of vascular complications, including hypertension, int...

Background and aimAbundant evidence suggests an association between thyroid disease and type 2 diabetes mellitus (T2DM). To determine the interaction between these co-existing pathologies, we analyzed insulin-treated type 2 diabetes patients with diagnosed thyroid disease.Patients and methodsThis retrospective study was performed in 54 type 2 diabetes patients who had been admitted for insulin-treatment and d...

BackgroundCeliac disease (CD) occurs in patients with type1 diabetes (T1DM) ranging the prevalence of 4.4–11.1% versus 0.5% of the general population. The mechanism of association of these two diseases involves a shared genetic background.AimTo investigate whether in type1 diabetes (T1DM) patients the concomitance of treated celiac disease (CD) impacts glycemic control and the prevalence of microvascular...

Background and aim: Gestational Diabetes Mellitus (GDM) is the commonest medical pregnancy complication. Nutritional interventions come to the fore as one of the few levers for managing GDM, as many medications are either harmful to the growing fetus, or their toxicity is uncertain. The aim of this study was to assess the potential clinical features and nutritional risk factors of insulin treatment during GDM.Methods: This was a prospective study includ...

Introduction: Hyperuricemia is associated with increased cardiovascular mortality and morbidity hence the interest in screening for hyperuricemia in the type 2 diabetic population.Objective: To investigate the association between hyperuricemia and degenerative complications in type 2 diabetics.Patients and Methods: This is a retrospective study including 130 patients followed in the C department of the National Institute of Nutriti...

Introduction: Dyslipidemia in type 1 diabetic patients is a frequent situation and seems to be a risk factor for the occurrence of degenerative complications. The aim of this study is to evaluate the lipid profile of type 1 diabetic patients and to study the relationship between dyslipedmia and the occurrence of degenerative complications.Method: This is a retrospective study conducted at the National Nutrition Institute of Tunis including 110 diabetic p...

Background and aim : To determine clinical and metabolic predictors of persistant abnormal glucose tolerance in post partum after gestational diabetes mellitus (GDM). Methods: This was a prospective study including 150 patients with GDM who underwent 75g oral glucose tolerance test (OGTT) at 4-12 weeks after delivery. Results: The prevalence of abnormal glucose tolerance in post partum after GDM was 32,8 % ,...

Introduction: Diabetic nephropathy is a a dreadfull complication of diabetes and it is the leading cause of chronic kidney disease worldwide. Hypertension is a major cause of progression of this complication.Objective: To determine the prevalence of diabetic nephropathy, to search a correlation between the presence and duration of arterial hypertension and the occurrence of diabetic nephropathy.Patients and methods: This is a retro...

Introduction: The association of hypertension and type 2 diabetes is frequent. These two pathologies constitute each a cardiovascular risk factor with a cumulative effect which increases the cardiovascular morbi-mortality of hypertensive diabetics.Objective: To measure and compare the frequency of degenerative complications of diabetes in hypertensive and non-hypertensive diabetics.Patients and method: The study was descriptive, re...

Introduction: Hypothyroidism is a frequent endocrinopathy in type 2 diabetes (T2D) which can influence the cardiovascular profile in these patients. Our aim was to study the relationship between hypothyroidism and the occurrence of cardiovascular events in patients with T2D.Method: It is a retrospective study, including 184 T2D patients, conducted in the department C of the National Institute of Nutrition of Tunis during the year 2021.<p class="abste...