Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep822 | Pituitary and Neuroendocrinology | ECE2022

Sheehan Syndrome effects on cardiovascular risk

Salah Ameni , Maaroufi Amel , Ajili Rihab , Benabdelkarim Asma , Njah Maha Kacem , Hasni Yosra , Ach Koussay

Introduction: Sheehan syndrome has been for a long time the most frequent cause of hypopituitarism among women in developing countries, including Tunisia. Apart from hormonal deficits caused by SS, young women with SS are exposed to an increased risk of cardiovascular mortality. In this study, we aimed to evaluate the cardiovascular risk in patients with SS. Patients and methods This is a descriptive cross-sectional study. It was carried out in the Endocrinology department of ...

ea0063p368 | Thyroid 1 | ECE2019

Glucocorticoid Functional Reserve in Hashimoto Hypothyroidism before and after LT4 replacement

Taieb Ach , Abdelkarim Asma Ben , Yosra Hasni , Amel Maaroufi , Maha Kacem , Molka Chaieb , Koussay Ach

Introduction: It has been generally accepted that adrenal function might be impaired in patients with primary hypothyroidism. A transitory low glucocorticoid production has been identified in cases with severe hypothyroidism. We tried to evaluate adrenocortical glucocorticoid function using the low-dose Synacthen test, in patients with primary hypothyroidism. The primary endpoint was to contrast the cortisol response to low-dose Synacthen before L-T4 replacement and after norm...

ea0063p778 | Thyroid 2 | ECE2019

Graves’ disease: woman or man, is there a difference in clinical presentation or evolution?

Chermiti Sondes , Hasni Yosra , Bayar Ines , Abdelkarim Asma , Kacem Maha , Chaieb Molka , Maaroufi Amel , Ach Koussay

Grave’s disease (GD), like all autoimmune diseases, is predominantly female, with sex ratio to 3 women for one man. The treatment of first intension is based on antithyroid drugs (ATD). Our objective is to compare the clinical presentation and the evolution of GD by gender. It’s a retrospective study. We studied patients with a first diagnosis of GD, in the department of endocrinology in Farhat Hached hospital in Susah, between Juanuary 2010 and December 2015. The pa...

ea0049ep441 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Diabetic nephropathy in type 1 diabetes mellitus

Barka Ines , Chikhrouhou Nesrine , Maaroufi Amel , Kacem Maha , Chaieb Molka , Ach Koussay

Nephropathy is a serious complication of Type 1 diabetes mellitus (T1DM) with a grave prognosis after the onset of proteinuria. End stage of renal disease remains the major cause of excess morbidity and premature mortality in patients with T1DM. The aims of the present study were to investigate the prevalence of diabetic nephropathy and to evaluate risk factors for its development among patients developing T1 DM. Seventy six patients with T1DM history over 20 years were includ...

ea0049ep646 | Obesity | ECE2017

Type 1 diabetes and metabolic syndrome

Taieb Ach , Yosra Hasni , Amel Maaroufi , Maha Kacem , Molka Chaieb , Koussay Ach

Introduction: Contrary to type 2 diabetes, type 1 often occurs in young people, without obesity or cardiovascular or metabolic diseases. The association of type 1 diabetes with an authentic metabolic syndrome including obesity is very rare, though possible, with a mixed clinical picture. The goal of our study is to evaluate the association of type 1 diabetes with the metabolic syndrome.Material and methods: This is a retrospective cross-sectional study b...

ea0049ep1229 | Thyroid (non-cancer) | ECE2017

Thyroid disorders and type 1 diabetes

Taieb Ach , Yosra Hasni , Amel Maaroufi , Maha Kacem , Molka Chaieb , Koussay Ach

Introduction: Type 1 Diabetes is an auto-immune disease caused by a disturbance of the immune system, damaging the Beta-cells. The association with other auto-immune diseases was frequently described, and dysthyroidism represents an important part of these associations. In type 1 diabetes, the hormonal profile can be disturbed regardless of auto-immunity. The goal of our study the thyroid hormonal profile in type 1 diabetes, as well as the prevalence of auto-immune dysthyroidi...

ea0049ep1389 | Thyroid (non-cancer) | ECE2017

Cytohistologic correlation of thyroid nodules

Barka Ines , Ouerdani Senda , Chaieb Molka , Ben Abdelkrim Asma , Maaroufi Amel , Kacem Maha , Ach Koussay

Background: The discovery of a thyroid nodule exposes the problem of the possibility of thyroid cancer. The difficulty of management of this situation is the fact that only the histopathological examination can confirm or refute the malignancy. Fine-needle aspiration (FNA) is used as a diagnostic tool to assess thyroid nodules. The purpose of our study is to correlate the clinical, ultasonographic, the FNA results and final pathology to determine the predictors of malignancy o...

ea0041ep53 | Adrenal cortex (to include Cushing's) | ECE2016

Ectopic expression of serotonin receptors in adrenocorticotropin-independent macronodular adrenal hyperplasia

Ghada Saad , Molka Chadli , Emna Dendana , Yosra Hasni , Amel Maaroufi , Maha Kacem , Kousay Ach

In ACTH-independent macronodular adrenal hyperplasia (AIMAH) causing Cushing’s syndrome, cortisol secretion is controlled by illegitimate membrane receptors. In the normal adrenal gland, agonists of 5-HT4 receptors have a powerful effect on aldosterone secretion but little effect on cortisol secretion in vitro.The aim of our study is to describe the clinical and hormonal features of patients diagnosed with aberrant serotonin receptor expres...

ea0041ep179 | Calcium and Vitamin D metabolism | ECE2016

Giant-cell tumor: hyperparathyroidisme is not always involved – a case report

Saad Ghada , Dendana Emna , Hasni Yosra , Kacem Maha , Maaroufi Amel , Chadli Molka , Ach Kousay

Giant-cell tumor is a skeletal disorder that occurs secondarily to hyperparathyroidism and is caused by long-term stimulation of parathyroid hormone (PTH) excess. The overactivity and proliferation of osteoclasts stimulated by PTH breaks down bone and leads to replacement of bone matrix and thinning of the cortex. True giant-cell tumor is a rare jaw osteolytic benign tumor belonging to the larger family of giant-cell tumors.We report the case of a 47 yea...

ea0041ep306 | Clinical case reports - Pituitary/Adrenal | ECE2016

Visual impairment revealing a growth hormone-producing pituitary adenoma in an 14-year-old boy: a case report

Barka Ines , Dendena Emna , Hasni Yosra , Maaroufi Amel , Kacem Maha , Chadli Molka , Ach Koussay

Background: Gigantism indicates excessive secretion of growth hormone (GH) during childhood Pituitary gigantism is very rare and the description of the disease is limited to small series and case reports. Here, we report a case of pituitary gigantism in a child revealed with visual defect.Case report: A 14-year-old boy presented with headache and left visual loss. On examination, he had visual acuity in his right eye of 2/10. His height was 178.0 cm (3 c...