Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep822 | Pituitary and Neuroendocrinology | ECE2022

Sheehan Syndrome effects on cardiovascular risk

Salah Ameni , Maaroufi Amel , Ajili Rihab , Benabdelkarim Asma , Njah Maha Kacem , Hasni Yosra , Ach Koussay

Introduction: Sheehan syndrome has been for a long time the most frequent cause of hypopituitarism among women in developing countries, including Tunisia. Apart from hormonal deficits caused by SS, young women with SS are exposed to an increased risk of cardiovascular mortality. In this study, we aimed to evaluate the cardiovascular risk in patients with SS. Patients and methods This is a descriptive cross-sectional study. It was carried out in the Endocrinology department of ...

ea0090p245 | Thyroid | ECE2023

Large rapidly developing goiter and Acute Leukemia

Ben Hadj Slama Nassim , Saad Ghada , Asma Gorchene , Elfekih Hamza , Kacem Maha , Molka Chadli

Introduction: Many thyroid conditions are associated with the development of a rapidly progressing goiter and should evoke several diagnoses, some of which may be of poor prognosis.Case-presentation: A 47-year-old female patient with no previous pathological history presented with a large goiter associated with a deteriorated general condition that had been evolving for 3 weeks On examination, she presented with a fever at 39°C, multiple cervical ad...

ea0090ep790 | Pituitary and Neuroendocrinology | ECE2023

Werner syndrome and endocrine involvement: A case report

Slama Nassim Ben Hadj , Saad Ghada , Asma Gorchene , Ach Taieb , Kacem Maha , Ach Koussay

Introduction: Werner syndrome is a rare genetic disease affecting the WRN gene, of autosomal recessive inheritance.Case-presentation: We report the case of a 34-year-old patient who presented with erectile dysfunction and asthenia. His brother underwent surgery for meningioma. He was also diagnosed with hypogonadism, suffered from bilateral cataract and diabetes, and died following acute Leukemia at the age of 35 years. Our patient is from a second-degre...

ea0063p368 | Thyroid 1 | ECE2019

Glucocorticoid Functional Reserve in Hashimoto Hypothyroidism before and after LT4 replacement

Taieb Ach , Abdelkarim Asma Ben , Yosra Hasni , Amel Maaroufi , Maha Kacem , Molka Chaieb , Koussay Ach

Introduction: It has been generally accepted that adrenal function might be impaired in patients with primary hypothyroidism. A transitory low glucocorticoid production has been identified in cases with severe hypothyroidism. We tried to evaluate adrenocortical glucocorticoid function using the low-dose Synacthen test, in patients with primary hypothyroidism. The primary endpoint was to contrast the cortisol response to low-dose Synacthen before L-T4 replacement and after norm...

ea0063p778 | Thyroid 2 | ECE2019

Graves’ disease: woman or man, is there a difference in clinical presentation or evolution?

Chermiti Sondes , Hasni Yosra , Bayar Ines , Abdelkarim Asma , Kacem Maha , Chaieb Molka , Maaroufi Amel , Ach Koussay

Grave’s disease (GD), like all autoimmune diseases, is predominantly female, with sex ratio to 3 women for one man. The treatment of first intension is based on antithyroid drugs (ATD). Our objective is to compare the clinical presentation and the evolution of GD by gender. It’s a retrospective study. We studied patients with a first diagnosis of GD, in the department of endocrinology in Farhat Hached hospital in Susah, between Juanuary 2010 and December 2015. The pa...

ea0049ep441 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Diabetic nephropathy in type 1 diabetes mellitus

Barka Ines , Chikhrouhou Nesrine , Maaroufi Amel , Kacem Maha , Chaieb Molka , Ach Koussay

Nephropathy is a serious complication of Type 1 diabetes mellitus (T1DM) with a grave prognosis after the onset of proteinuria. End stage of renal disease remains the major cause of excess morbidity and premature mortality in patients with T1DM. The aims of the present study were to investigate the prevalence of diabetic nephropathy and to evaluate risk factors for its development among patients developing T1 DM. Seventy six patients with T1DM history over 20 years were includ...

ea0049ep646 | Obesity | ECE2017

Type 1 diabetes and metabolic syndrome

Taieb Ach , Yosra Hasni , Amel Maaroufi , Maha Kacem , Molka Chaieb , Koussay Ach

Introduction: Contrary to type 2 diabetes, type 1 often occurs in young people, without obesity or cardiovascular or metabolic diseases. The association of type 1 diabetes with an authentic metabolic syndrome including obesity is very rare, though possible, with a mixed clinical picture. The goal of our study is to evaluate the association of type 1 diabetes with the metabolic syndrome.Material and methods: This is a retrospective cross-sectional study b...

ea0049ep1229 | Thyroid (non-cancer) | ECE2017

Thyroid disorders and type 1 diabetes

Taieb Ach , Yosra Hasni , Amel Maaroufi , Maha Kacem , Molka Chaieb , Koussay Ach

Introduction: Type 1 Diabetes is an auto-immune disease caused by a disturbance of the immune system, damaging the Beta-cells. The association with other auto-immune diseases was frequently described, and dysthyroidism represents an important part of these associations. In type 1 diabetes, the hormonal profile can be disturbed regardless of auto-immunity. The goal of our study the thyroid hormonal profile in type 1 diabetes, as well as the prevalence of auto-immune dysthyroidi...

ea0049ep1389 | Thyroid (non-cancer) | ECE2017

Cytohistologic correlation of thyroid nodules

Barka Ines , Ouerdani Senda , Chaieb Molka , Ben Abdelkrim Asma , Maaroufi Amel , Kacem Maha , Ach Koussay

Background: The discovery of a thyroid nodule exposes the problem of the possibility of thyroid cancer. The difficulty of management of this situation is the fact that only the histopathological examination can confirm or refute the malignancy. Fine-needle aspiration (FNA) is used as a diagnostic tool to assess thyroid nodules. The purpose of our study is to correlate the clinical, ultasonographic, the FNA results and final pathology to determine the predictors of malignancy o...

ea0041ep53 | Adrenal cortex (to include Cushing's) | ECE2016

Ectopic expression of serotonin receptors in adrenocorticotropin-independent macronodular adrenal hyperplasia

Ghada Saad , Molka Chadli , Emna Dendana , Yosra Hasni , Amel Maaroufi , Maha Kacem , Kousay Ach

In ACTH-independent macronodular adrenal hyperplasia (AIMAH) causing Cushing’s syndrome, cortisol secretion is controlled by illegitimate membrane receptors. In the normal adrenal gland, agonists of 5-HT4 receptors have a powerful effect on aldosterone secretion but little effect on cortisol secretion in vitro.The aim of our study is to describe the clinical and hormonal features of patients diagnosed with aberrant serotonin receptor expres...