Endocrine Abstracts

Background: Sarcopenia is associated with mortality in patients with chronic kidney disease (CKD). However, the extent to which sarcopenia contributes to this risk, either independently or in conjunction with metabolic abnormalities and frailty, remains unclear. Therefore, this study aimed to explore the associations among sarcopenia, frailty, central obesity, metabolic abnormalities, cardiovascular risks, and mortality.Methods: This study used data from...

Tetrabromobisphenol A (TBBPA) is a brominated flame retardant and is widely used in electronic goods, plastics, and furniture. TBBPA is frequently detected in water, soil, organisms and even in human breast milk. Though some regulatory agencies have asserted that consumer exposures to TBBPA are unlikely to have adverse implications for human health, the reported evidence of endocrine-disruption of TBBPA has raised concerns regarding its effects on neurodevelopment and behavior...

Background: Distant metastasis rarely occurs in differentiated thyroid carcinoma (DTC), but represents most common cause of death in patients with DTC. Lung and bone are the most frequent sites of distant metastases. This study investigated long term outcomes of lung metastasis in DTC patients and its prognostic factors influencing disease progression and cancer specific survival (CSS).Methods: A total of 134 DTC patients presenting with lung metastasis ...

Background: Early detection of residual or recurrent cancer in patients with differentiated thyroid cancer (DTC) is important, especially, when they do not uptake 131I uptake because these tumors do not likely benefit from radioiodine therapy (RAIT). We aimed to evaluate the usefulness of FDG-PET/CT as an early diagnostic work up in DTC patients with negative radioiodine whole body scan (I-WBS) and elevated stimulated Tg (sTg) levels.Methods: ...

Background: Urinary metanephrine (MN) and normetanephrine (NMN) are used to detect recurrence of pheochromocytoma during post-operative period. Currently, reference ranges of urinary MN and NMN obtained from healthy individuals are applied to subjects with adrenalectomy. However, studies regarding the property of using reference ranges from healthy subjects in pheochromocytoma subjects with adrenalectomy are limited.Aim: To compare urinary MN and NMN con...

Background/aims: Maternal subclinical hypothyroidism has been reported to be associated with risks of adverse pregnancy outcomes such as fetal loss and possible fetal neurodevelopmental deficit. However, current guidelines seem to overestimate subclinical hypothyroidism in pregnant women in some regions. Therefore, we aim to evaluate trimester-specific reference range of serum TSH for pregnant women in Korea and whether maternal subclinical hypothyroidism affects perinatal out...

Introduction: There are few cases about arterial thrombosis combined with thyrotoxicosis independent of atrial arrhythmias. Herein, we report a case of Graves’ disease presented with renal artery infarction withiout atrial fibrillation.Case: A 54-year-old man visited the emergency department due to the sudden onset of left flank pain for 30 min. The left flank pain was accompanied by sole dysuria without other symptoms of pyelonephritis. Physical ex...

Introduction: The degree of dyslipidemia caused by iatrogenic hypothyroidism is not clear in DTC. Therefore, we investigated the average of lipid profile change caused by LT4 withdrawal in the follow-up of DTC.Method: We enrolled 84 DTC patients who underwent high-dose RAI therapy for the treatment of recurred or remnant DTC and we measured serum levels of total cholesterol, triglyceride, LDL, and HDL and then analyzed changes in them accordin...

Introduction: The prevalence of B-type Raf kinase (BRAFV600E) mutation in PTC has been observed in 30% to over 80%, and it seems that the mutation occurred in the early stage of thyroid carcinoma progression which precedes histological change. Based on previous reports, high body mass index (BMI) is considered a thyroid cancer risk. However, it is unclear whether high BMI has a certain association with the BRAFV600E mutational status. We assess whether high BMI is associated w...

Somatostatin analogues (SSA) are widely used for the treatment of patients with acromegaly, and the responses are variable. We investigated the possible predictive factors of the response to SSA therapy in Korean acromegalic patients. Twenty-eight patients were retrospectively analysed, who were treated by surgery and adjunctively SSA. Somatostatin suppression tests (SST, hourly GH measurements for 3 h following 100 μg somatostatin injection) were done before SSAs were gi...