Searchable abstracts of presentations at key conferences in endocrinology

ea0035p349 | Diabetes (epidemiology, pathophysiology) | ECE2014

Profile of type 2 diabetic patients according to HbA1c tertiles in our tertiary health care center

Yurekli Banu Sarer , Kocabas Gokcen Unal

Aim: In this study we aimed to investigate general properties and treatment modalities of our type 2 diabetic patients.Materials and methods: A total of 136 consecutive type 2 diabetic patients were investigated. Type 2 diabetic patients were divided into three different groups according to HbA1c level (<7% group 1, 7–9% group 2, >9% group 3).Results: Mean age of our type 2 diabetic patients (F n=95, M n</...

ea0035p465 | Diabetes therapy | ECE2014

Metabolic control of our turkish diabetic patients on exenatide therapy: good at metabolic control but how about compliance?

Mirili Cem , Yurekli Banu Sarer , Kocabas Gokcen Unal , Kaya Zubeyde

Objective: Our aim is to evaluate the effect of exenatide treatment on body weight, HbA1c and compliance to treatment.Material and method: A total of 36 (five M and 31 F) type 2 diabetic patients who were prescribed exenatide were evaluated for this study. Body weight, BMI, HbA1c parameters and side effects were noted from the outpatient clinic records.Result: The median age of our patients was 52 years of old (19–79 years). M...

ea0035p1024 | Thyroid (non-cancer) | ECE2014

A case of thyrotoxic hypokalemic periodic paralysis presenting with ‘U’ wave on ECG

Gezer Emre , Yurekli Banu Sarer , Kocabas Gokcen Unal

Introduction: Hypokalemic periodic paralysis (HPP), is a rare neuromuscular disorder caused by dysfunction of the ion channels in red muscle cells which is characterized by painless episodes of muscle weakness generally after strenuous exertion or a high-carbohydrate meal. However, some HPP patients secondary to thyrotoxicosis are also described.Case: A 41-year-old Caucasian man, without any chronic disease, presented to our emergency department with gen...

ea0041ep672 | Female Reproduction | ECE2016

The association between increased circulating irisin levels and inflammatory markers in polycystic ovary syndrome

Yildiz Nurdan , Calan Mehmet , Cobanoglu Minegul , Sengul Hatice İsik , Kocabas Gokcen Unal , Guclu Serkan

Purpose: Irisin is a secreted protein implicated in the regulation of insulin sensitivity and energy metabolism. Polycystic ovary syndrome (PCOS) is an inflammatory-based metabolic disease associated with insulin resistance, dyslipidemia, glucose metabolism dysfunction and obesity. There is also some evidence of a link between irisin and inflammation. Our aim of the study to ascertain whether the association of circulating irisin levels with inflammatory markers in PCOS.<p...

ea0035p406 | Diabetes complications | ECE2014

Is the ankle-brachial index directly associated with current glycemic control in diabetic patients? Preliminary results of our study

Yurekli Banu Sarer , Kocabas Gokcen Unal , Mirili Cem , Yurekli Ismail , Cakir Habib

Introduction: Association between ankle-brachial index (ABI) and coronary, cerebral, and peripheral vessels involvement has been shown in different studies. The normal range of ABI is between 0.9 and 1.4. Values below 0.9 show peripheral vessel disease. An ABI more than 1.4 is characteristic for vascular rigidity. We aimed to investigate the ABI value in our type 2 diabetic patients and association of ABI with glycemic control.Materials and methods: This...

ea0035p1107 | Thyroid Cancer | ECE2014

Effects of zoledronic acid monohydrate on cytotoxicity and apoptosis in BCPAP human papillary thyroid carcinoma cell line

Simsir Ilgin Yildirim , Kocabas Gokcen Unal , Yurekli Banu Pinar Sarer , Avci Cigir Biray , Saygili Lutfiye Fusun

Thyroid cancer in Turkey is the most common endocrine neoplasm with an incidence of 3.7%. Papillary thyroid carcinoma is the most common thyroid malignancy in a similar manner. Papillary thyroid carcinoma creates 50–90% of differentiated thyroid carcinomas. There is available in subgroups with poor prognosis. Case-specific mortality of 2% at 5, 10, and 20 years, only 4 and 5%.Mutations and re-arrangements in genes encoding proteins of the MAPK pathw...

ea0037ep219 | Reproduction, endocrine disruptors and signalling | ECE2015

The relationships of bisphenol A levels with leptin and adiponectin in premenopausal women

Polat Sevgi , Yurekli Banu Sarer , Kocabas Gokcen Unal , Durusoy Raika , Aksit Murat , Bozkaya Giray , Yuksel Arif , Saygili Fusun

Aim: Bisphenol A (BPA) is the most common endocrine disruptor among environmental estrogens. BPA is an ingredient that is commonly used in polycarbonate plastics. In this study, our main concern is to measure the levels of BPA in premenopausal obese women and to examine the relationship of BPA with adiponectin and leptin.Materials and methods: 47 obese women and 39 non-obese healthy women were enrolled in this study. All participants were premenopausal. ...

ea0041ep660 | Female Reproduction | ECE2016

Increased adipsin is associated with carotid intima media thickness and metabolic disturbances in polycystic ovary syndrome

Kocabas Gokcen Unal , Calan Ozlem Gursoy , Calan Mehmet , Senses Pinar Yesil , Ozden Ebru , Sari Kerime Rumeysa , Aktar Merve Kocar , Imamoglu Cetin , Senses Yasar Mehmet , Bozkaya Giray , Bilgir Oktay

Context: Adipsin, a protein secreted mainly from the adipose tissue, is a structural homologous of complement factor D, a rate-limiting enzyme of the alternative complement system. Growing evidence suggests that the alternative complement system plays a role both in the regulation of energy homeostasis and the atherosclerotic process. Polycystic ovary syndrome (PCOS) is an inflammatory based-metabolic disease.Objective: To ascertain whether circulating a...

ea0037ep153 | Reproduction, endocrine disruptors and signalling | ECE2015

A possible link between LH and macrophage migration inhibitory factor levels in polycystic ovary syndrome

Calan Mehmet , Kume Tuncay , Yilmaz OzgUr , Arkan Tugba , Kocabas Gokcen Unal , Dokuzlar Ozge , Aygun Kemal , Oktan Mehmet Asi , Danis Nilay , Temur Muzaffer

Purpose: Macrophage migration inhibitory factor (MIF) is a multi-functional cytokine which plays a role in metabolic and inflammatory processes. Increasing evidence suggests that there is a link between MIF and ovulation. We aimed to evaluate plasma MIF levels in women with polycystic ovary syndrome (PCOS) and to determine whether MIF levels differ between the follicular phase and mid-cycle of the menstrual cycle in eumenorrheic women.Methods: Ninety wom...

ea0056p812 | Pituitary - Clinical | ECE2018

Is elevated urotensin II level a predictor for increased cardiovascular risk in subjects with acromegaly?

Demirpence Mustafa , Guler Asli , Yilmaz Hamiyet , Sayin Ahmet , Pekcevik Yeliz , Turkon Hakan , Colak Ayfer , Ari Elif Merve , Aslanipour Behnaz , Kocabas Gokcen Unal , Calan Mehmet

Purpose: Acromegaly, an uncommon disease, is existed in the result of over production of growth hormone (GH). It is associated with increased cardiovascular risk factors and metabolic abnormalities. Urotensin II (UII), a secreted vasoactive peptide hormone, plays an essential role in the regulation of vascular tone, glucose metabolism and atherosclerosis. UII belonging to somatostatin superfamily activates somatostatin receptors as well. The aim of this study was to ascertain ...