Searchable abstracts of presentations at key conferences in endocrinology

ea0020p673 | Steroid Receptors | ECE2009

Non-classical rapid effects of glucocorticoids on the beta cell function in response to glucose in healthy men

Vila Greisa , Krebs Michael , Baumgartner-Parzer Sabina , Riedl Michaela , Clodi Martin , Pacini Giovanni , Luger Anton

Glucocorticoids suppress insulin secretion, inhibit glucose uptake in peripheral tissues, and promote gluconeogenesis in the liver. These effects are known to be mediated via genomic mechanisms of slow onset. Despite recent evidence on rapid non-genomic glucocorticoid signaling in several organs, there is no information on rapid glucocorticoid effects on carbohydrate metabolism in humans.Here we present data on the rapid effects of hydrocortisone on the ...

ea0056p47 | Adrenal cortex (to include Cushing's) | ECE2018

The renin-angiotensin-aldosteron system in primary adrenal insufficiency

Wolf Peter , Mayr Johanna , Poglitsch Marko , Gessl Alois , Luger Anton , Winhofer Yvonne , Krebs Michael

Background: Despite adequate hormone replacement therapy, evidence suggests that mortality is increased in patients suffering from primary adrenal insufficiency (AI), mainly because of cardiovascular diseases. Since activation of the renin-angiotensin-aldosteron system (RAAS) plays an important role in the development of hypertension and cardiovascular disease we aimed to investigate, if there are differences in AI compared to healthy controls.Methods: E...

ea0041gp51 | Cardiovascular endocrinology | ECE2016

Pericardial rather than intramyocardial fat is independently associated with systolic and diastolic left ventricular heart function in metabolically healthy humans

Wolf Peter , Winhofer Yvonne , Smajis Sabina , Jankovic Drazenka , Anderwald Christian-Heinz , Trattnig Siegfried , Luger Anton , Krebs Michael , Krssak Martin

Background: Obesity is a major risk factor to develop heart failure, in part due to possible lipotoxic effects of increased intramyocardial (MYCL) and/or pericardial (PERI) lipid accumulation. Recent evidence suggests that MYCL is highly dynamic and might rather be a surrogate marker for disturbed energy metabolism than the underlying cause of cardiac dysfunction. On the other hand, PERI might contribute directly by mechanic and paracrine effects. Therefore, we hypothesized th...

ea0035p129 | Calcium and Vitamin D metabolism | ECE2014

Cardio-metabolic phenotyping of patients with familiar hypocalciuric hypercalcemia

Wolf Peter , Krssak Martin , Winhofer Yvonne , Anderwald Christian , Zwettler Elisabeth , Trattnig Siegfried , Luger Anton , Baumgartner-Parzer Sabina , Krebs Michael

Introduction: Heterozygous inactivating mutations of the calcium sensing receptor (CaSR) gene cause mild alterations in calcium metabolism (familiar hypocalciuric hypercalcemia (FHH)). However, in addition to the parathyroid gland CaSR expression was recently identified in the myocardium and many other endocrine cells including pancreatic islet cells, entero-endocine cells and adipose tissue. So far, it is unknown whether FHH is associated with cardio-metabolic altera...

ea0070aep794 | Reproductive and Developmental Endocrinology | ECE2020

Investigating the impact of preoperative obesity-associated hyperandrogenemia in women and hypogonadism in men on weight loss following bariatric surgery

Beiglböck Hannes , Fellinger Paul , Ranzenberger-Haider Tamara , Itariu Bianca , Prager Gerhard , Kautzky-Willer Alexandra , Krebs Michael , Wolf Peter

Background: In severe obesity, hypogonadism in men and androgen excess in women are frequently observed. Sex hormones play an important role in body composition, glucose and lipid metabolism. Bariatric surgery is the most effective treatment strategy to combat morbid obesity. However, if preoperative gonadal dysfunction impacts weight loss and metabolic improvements after surgery is not known.Methods: 49 men and 104 women were included in a retrospective...

ea0070ep341 | Pituitary and Neuroendocrinology | ECE2020

Long-term-follow-up of patients with gastric bypass surgery secondary to craniopharyngioma associated hypothalamic obesity

Beiglböck Hannes , Fellinger Paul , Ranzenberger-Haider Tamara , Vila Greisa , Luger Anton , Kautzky-Willer Alexandra , Krebs Michael , Wolf Peter

Background: Patients being cured of craniopharyngioma (CP) often suffer from severe hypothalamic obesity due to tumor localization or therapeutic interventions, which has a major impact on increased mortality and reduced quality of life. Gastric bypass surgery (GBS) was suggested to be an effective therapeutic option for weight reduction in those patients. However, long-term changes in body weight and postsurgical complications are unknown.Methods: 5 pat...

ea0014oc12.1 | Diabetes | ECE2007

Hypoglycemia and cerebral ATP synthesis in Type 1 Diabetes

Mandl Martina , Zbyn Stefan , Mlynarik Vladimir , Promintzer Miriam , Luger Anton , Krebs Michael , Anderwald Christian , Bischof Martin G.

The mechanisms responsible for the progressive failure of hypoglycemia counter-regulation in type-1 diabetes (T1DM) are poorly understood. Alterations of brain energy metabolism could influence glucose sensing by the brain and, thus contribute to hypoglycemia associated autonomic failure. Thus, we measured intraneuronal kinetics of total ATP-synthesis from PCr (kfor) in T1DM patients and effects of hypo/hyperglycemia on this brain energy metabolism. Healthy n...

ea0014p68 | (1) | ECE2007

Circulating retinol binding protein 4 and protein C inhibitor are not related to insulin resistance

Promintzer Miriam , Krebs Michael , Luger Anton , Bischof Martin Georg , Nowotny Peter , Binder Christoph , Esterbauer Harald , Anderwald Christian

Recent data suggest that circulating retinol binding protein-4 (RBP4) is involved in the pathogenesis of insulin resistance in rodents and humans. Moreover, protein C inhibitor (PCI) which specifically binds retinoic acid was found to be increased in myocardial infarction survivors who are also insulin-resistant.Therefore, we investigated the association of insulin resistance with plasma retinol binding factors (RBP4 and PCI active antigen) in nondiabeti...

ea0014p261 | (1) | ECE2007

Hepatic and brain metabolism in young adults with glycogen storage disease type 1

Mandl Martina , Weghuber Daniel , Krssak Martin , Roden Michael , Nowotny Peter , Brehm Atilla , Krebs Michael , Widhalm Kurt , Bischof Martin

Glycogen storage disease type 1 (GSD1) is a rare inherited defect of endogenous glucose production. While children present with severe hypoglycemia the propensity for hypoglycemia may decrease with age in these patients. It was the aim of this study to elucidate the mechanisms for milder hypoglycemia symptoms in grown up GSD1 patients. Four patients with GSD1 (BMI: 23.2±6.3 kg/m2, age: 21±3 yr) and four healthy controls matched for BMI (23.1±3.0 kg/m<...

ea0081p403 | Pituitary and Neuroendocrinology | ECE2022

GH/IGF-I impact hepatic lipid accumulation in non-acromegalic individuals with and without non-alcoholic fatty liver disease

Fellinger Paul , Beiglboeck Hannes , Pfleger Lorenz , Smajis Sabina , Gajdosik Martin , Marculescu Rodrig , Vila Greisa , Winhofer Yvonne , Kautzky-Willer Alexandra , Krebs Michael , Krssak Martin , Wolf Peter

Background: Growth hormone (GH) plays an important role in modifying body composition. In acromegaly, a state of chronic GH/IGF-I excess, visceral and ectopic fat mass, especially in the liver, are significantly reduced. The aim of this study was to investigate the impact of GH/IGF-I on hepatocellular lipid content (HCL) and energy metabolism in a non-acromegalic cohort of patients with and without non-alcoholic fatty liver disease (NAFLD).Methods: We pe...