Searchable abstracts of presentations at key conferences in endocrinology

ea0035p666 | Female reproduction | ECE2014

Does polycystic ovary syndrome influence incidence nonalcoholic fatty liver disease in women?

Bohdanowicz-Pawlak Anna , Laczmanski Lukasz , Milewicz Andrzej

The aim was to assess associations among metabolic abnormalities in polycystic ovary syndrome (PCOS) and NAFLD.Materials and methods: In 184 women with PCOS and 125 healthy premenopausal volunteers sex steroids, lipids, glucose, insulin, aminotranspherases, CRP, free androgen index (FAI), HOMA and E2:testosterone were calculated. Hepatic steatosis was determined by ultrasound. The analysis of multivariate (logistic regression) due to the prese...

ea0035p152 | Calcium and Vitamin D metabolism | ECE2014

The effect of VDR polymorphisms on serum testosterone level in aging men population

Laczmanski Lukasz , Lwow Felicja , Kolackov Katarzyna , Milewicz Andrzej

The aim of this study was to determine whether polymorphisms (TaqI, ApaI, BsmI, and FokI) of the vitamin D receptor (VDR) show a correlation with the serum level of the testosterone in the aging men population.A group of 224 men aged 65–90 years, randomly selected from the group of 5695 persons included in the PolSenior project was studied. We established genotype prevalence of the VDR gene polymorphisms (TaqI, rs10735810; ApaI, rs1544410; BsmI, rs7...

ea0020p480 | Obesity and Metabolism | ECE2009

Serum adiponectin levels and polymorphism of CB1 endocannabinoid receptor (A3813G, A4895G, G1422A) in postmenopausal women

Jedrzejuk Diana , Lwow Felicja , Dunajska Katarzyna , Laczmanski Lukasz , Milewicz Andrzej

Recently, low serum adiponectin levels is created as a new risk factor for cardiovascular diseases in climacteric women. Our previous study shows that smoking, serum testosterone levels, blood pressure and BMI have the influence on serum adiponectin levels. Endocannabinoid system plays a role in regulation of food intake and fat accumulation, as well as lipid and carbohydrate metabolism. Menopause transition is related to metabolic disorders (e.g. obesity) and cause the increa...

ea0041ep226 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Lipid accumulation product (LAP) and waist circumference to height ratio (WHtR) associated with free androgen index but not with serum testosterone and androstendione in women with PCOS

Kuliczkowska-Plaksej Justyna , Milewicz Andrzej , Laczmanski Lukasz , Jedrzejuk Diana , Lwow Felicja , Bolanowski Marek

Introduction: Polycystic ovary syndrome (PCOS) is associated with metabolic disorders such as insulin resistance, hyperinsulinemia, dyslipidemia and central obesity which increase the risk of cardiovascular diseases (CVD). Lipid accumulation product (LAP) and waist circumference to height ratio (WHtR) are novel CVD risk predictors based on the assessment of waist circumference, height and serum triglycerides. The aim of our study was to evaluate the LAP and WHtR associations w...

ea0037ep343 | Diabetes (pathiophysiology & epitemiology) | ECE2015

Irisin plasma level is connected with the android adipose tissue deposit

Pukajlo Katarzyna , Kolackov Katarzyna , Laczmanski Lukasz , Kuliczkowska-Plaksej Justyna , Bolanowski Marek , Milewicz Andrzej , Daroszewski Jacek

Irisin (Ir), a recently identified adipomyokine, cleaved and secreted to the circulation from the FNDC5 protein in response to physical activity and some environmental conditions has been postulated to induces the differentiation of a subset of white adipocytes into brown fat and mediates the beneficial effects of exercise on metabolic homeostasis. Polycystic ovary syndrome (PCOS) – one of the most frequent endocrinopathies affecting women of child-bearing age is associat...

ea0037ep344 | Diabetes (pathiophysiology & epitemiology) | ECE2015

The GH treatment results in the increase of irisin concentration in plasma

Wikiera Beata , Pukajlo Katarzyna , Laczmanski Lukasz , Sloka Natalia , Basiak Aleksander , Bolanowski Marek , Noczynska Anna , Daroszewski Jacek

Brown adipose tissue metabolism is of remarkable pathophysiological interest, because it could be a target for future therapies for obesity and metabolic syndrome. Irisin (Ir), recently identified novel adipomyokine is essential in a white-to-brown fatty tissue transdifferentiation, and mediates some of the positive influences on metabolic disorders through increase of energy expenditure. The exact regulation of Ir secretion and action is unknown but significant positive assoc...

ea0035p127 | Calcium and Vitamin D metabolism | ECE2014

VDR gene polymorphisms in Alzheimer's disease: pilot study

Laczmanski Lukasz , Jakubik Marta , Rymaszewska Joanna , Bednarek-Tupikowska Grazyna , Lwow Felicja , Sloka Natalia , Milewicz Andrzej

Aggravation of the symptoms of Alzheimer’s disease may also underlie the functioning of receptors associated with calcium and vitamin D. Therefore, it seems reasonable to study the correlation of polymorphisms of vitamin D receptor (VDR) and calcium receptor (CASR) with symptoms of AD. Alzheimer’s disease, vitamin D deficiency and osteoporosis often coexist in the patient. Research suggests that vitamin D deficiency is much more frequent in the patients with AD. Expr...

ea0035p758 | Obesity | ECE2014

Irisin plasma concentration in PCOS and healthy subjects is related to body adipose content

Pukajlo Katarzyna , Kolackov Katarzyna , Laczmanski Lukasz , Kuliczkowska-Plaksej Justyna , Lenarcik-Kabza Agnieszka , Milewicz Andrzej , Daroszewski Jacek

Polycystic ovary syndrome (PCOS) is a common endocrine abnormality connected not only with reproductive problems but also with impaired energy homeostasis leading to metabolic disorders including metabolic syndrome. Irisin (Ir), recently identified novel myokine, has been proposed to mediate some of the positive influence on metabolic disorders. The aim of our study was to search the relationship between Ir plasma concentration in PCOS in the context of metabolic disturbances....

ea0035p759 | Obesity | ECE2014

May the FTO gene affect visceral obesity? Study of variant rs9930506 SNP among the MONW in a Polish population

Kolackov Katarzyna , Laczmanski Lukasz , Tupikowska Malgorzata , Zdrojowy-Welna Aleksandra , Bednarek-Tupikowska Grazyna

Objective: Genetic factors play a major role in obesity. Numerous studies have confirmed associations of the SNP rs9930506 of FTO gene with increased BMI, hip circumference and total body weight. The metabolic consequences of obesity depend, to a large degree, on body fat distribution.MONW individuals (metabolically obese normal-weight), despite their normal BMI, are characterized by visceral obesity and display metabolic properties that may pre...

ea0022p698 | Obesity | ECE2010

Abdominal fat, insulin sensitivity, inflammatory atheromatosis risk factors and polymorphisms of 174-G/C IL-6 promoter and Pro12Ala PPARγ in non-obese subjects

Bednarek-Tupikowska Grazyna , Kubicka Eliza , Tworowska-Bardzinska Urszula , Laczmanski Lukasz , Bolanowski Marek , Milewicz Andrzej

Some individuals with normal weight but probably visceral fat excess, called Metabolically Obese Normal-Weight (MONW), have disturbances typical for metabolic syndrome. We analyzed relationships between body fat distribution (estimated by DXA) and insulin resistance, serum inflammatory markers levels (CRP, IL-6, IL-18) and polymorphisms of IL-6 promoter and PPARγ in healthy, non-obese Polish subjects: 232 women (age 31.4±5.5; BMI 21.5±2.5) and 199 men (age 30.3&...