Searchable abstracts of presentations at key conferences in endocrinology

ea0032p894 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Familiar panhypopituitarism by a mutation in PROP1: four of seven brothers affected

Lau Eva , Freitas Paula , Coutinho Eduarda , Lemos Manuel , Carvalho Davide

Introduction: Generously supported by IPSEN)-->PROP1 (Prophet of Pit-1) mutations are the most frequent genetic cause of panhypopituitarism, a condition associated with a deficiency or inadequate production of hormones of the anterior pituitary. The PROP1 gene encodes a transcription factor involved in the ontogeny, differentiation and function of somatotrophs, lactotrophs and thyrotrophs. These mutations are characterized by a remar...

ea0041ep632 | Endocrine tumours and neoplasia | ECE2016

Evaluation of the incidence and clinical characteristics of glucose metabolism alterations during the follow-up of surgically treated insulinomas

Sergio Neves Joao , Lau Eva , Oliveira Joana , Isabel Oliveira Ana , Freitas Paula , Carvalho Davide

Introduction: The incidence of glucose metabolism alterations during the follow-up of surgically treated insulinomas is largely unknown. Our aim was to evaluate the incidence, and the clinical characteristics, of diabetes and prediabetes in this population.Methods: We retrospectively analyzed the cases diagnosed as insulinomas in a Central Hospital in Portugal in the period between January 1980 and December 2015.Results: We identif...

ea0040p16 | (1) | ESEBEC2016

Insulinomas at São João Hospital between 1980 and 2015

Neves Joao Sergio , Lau Eva , Oliveira Joana , Oliveira Ana Isabel , Freitas Paula , Carvalho Davide

Introduction: Insulinomas are pancreatic endocrine tumors originating in the beta cells, characterized by hypoglycemia resulting from insulin hypersecretion.Objectives: To characterize the demography, the clinical features, imagiological findings and pathological evaluation of the cases of insulinomas identified in the previous 35 years at São João Hospital.Methods: We retrospectively analyzed the cases diagnosed as insul...

ea0037ep641 | Obesity and cardiovascular endocrinology | ECE2015

Body composition in HIV-infected patients under combined antiretroviral therapy over 5 years

Grenha Ines , Oliveira Joana , Lau Eva , Vieira Romana , Serrao Rosario , Sarmento Antonio , Carvalho Davide , Freitas Paula

Introduction: HIV infection and combined antiretroviral therapy (cART) have been associated with lipodistrophy and changes in body composition. However, there are few studies on body composition evolution of HIV-infected patients, under cART.Aims: To evaluate the evolution of body composition in HIV-1 infected patients under cART over 5 years.Methods: Retrospective, observational study in a cohort of HIV-infected patients on cART. ...

ea0037ep724 | Pituitary: clinical | ECE2015

Serum cortisol in the early postoperative period as predictor of remission in Cushing's disease

Oliveira Joana , Lau Eva , Belo Sandra , Freitas Paula , Vinha Eduardo , Pereira Josue , Castro Ligia , Carvalho Davide

Introduction: Pituitary surgery is currently considered the preferred treatment for Cushing’s disease (CD) and achieves remission in 55–85% of patients. Cortisol falls quickly after surgery, so that early post-operative cortisol level has been used as predictor of remission. There’s no agreement about optimal timing for cortisol measurement, with wide variability between centres.Objective: To assess the value of early post-operative serum ...

ea0037ep725 | Pituitary: clinical | ECE2015

Predictive factors for remission and recurrence in Cushing's disease: a single-centre study

Oliveira Joana , Lau Eva , Belo Sandra , Freitas Paula , Vinha Eduardo , Pereira Josue , Castro Ligia , Carvalho Davide

Introduction: Cushing’s disease (CD) is characterised by pathologic hypercortisolism caused by an ACTH-secreting pituitary adenoma. The primary modality for definitive treatment is pituitary surgery. The rarity of CD has made it difficult to establish reliable predictive factors of outcomes.Aim: Assessment of clinical, hormonal, radiological, surgical and histological findings as predictors of remission and relapse of CD.Metho...

ea0035p17 | Adrenal cortex | ECE2014

Female to male gender identity disorder in a patient with non-classical congenital adrenal hyperplasia

Lau Eva , Castedo Jose Luis , Rodrigues Pedro , Figueiredo Zelia , Carvalho Davide

Introduction: Congenital adrenal hyperplasia (CAH) is a prevalent disturb in female to male gender identity disorder (GID). However, psychoendocrinology of GID is not yet fully understood.Case Report: A 22-year-old patient(46, XX), was sent from Psychiatry-Sexology to Endocrinology consultation for GID to start hormonal treatment. Self-awareness as a male began at 12-year-old. Menarche at the age of 13 years. At 14-year-old, it was noticed overgrowth of ...

ea0035p450 | Diabetes complications | ECE2014

Diabetic neuropathy in a young patient with recently diagnosed diabetes mellitus: an atypical presentation of insulin neuritis

Esteves Cesar , Neves Manuel Celestino , Lau Eva , Meneses Joana , Jorge Georgina , Carvalho Davide

Introduction: Insulin neuritis is a rare form of presentation of diabetic neuropathy, usually associated with the sudden intensification of glucose control in individuals with long standing uncontrolled diabetes mellitus.Objectives: To report a case of insulin neuritis in a young male, few weeks after diagnosis and insulin therapy initiation.Clinical case: Male, 22 years old, previous history of excess weight until he was 19 years ...

ea0032p1027 | Thyroid (non-cancer) | ECE2013

Thyroid diffuse lipomatosis: a rare and benign disease

Lau Eva , Freitas Paula , Goncalves Frederica , Pardal Joana , Eloy Catarina , Matos-Lima Luis , Carvalho Davide

Introduction: Diffuse lipomatosis of the thyroid is a very rare disease, characterized by extensive infiltration of thyroid parenchyma by mature adipose tissue. It is not accompanied by accumulation of amyloid fibrils.Clinical report: Male, 47 years old, followed in Endocrinology by hypothyroidism, since 13 years old, medicated with levothyroxine, with unremarkable growth and pshicomotor development. In 2002, thyroid echography showed a solid and heterog...

ea0049ep195 | Endocrine tumours and neoplasia | ECE2017

Malignant pheochromocytoma – a challenging diagnosis with nonconsensual management

Castro Oliveira Sofia , Sergio Neves Joao , Souteiro Pedro , Lau Eva , Isabel Oliveira Ana , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: Pheochromocytomas and extra-adrenal paragangliomas are rare neuroendocrine tumors, with a peak incidence between the 3rd–5th decades of life and about 10% are malignant. Although they have the same radiographic and histologic characteristics of their benign counterpart, malignant pheochromocytomas are diagnosed by the presence of local invasion or metastatic tumor in the non-chromaffin tissues, and offer a poorer prognosis. Treatment is typically extirpative...