Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc4.3 | Neuroendocriology basis | ECE2007

Absence of germline AIP mutations in early onset sporadic somatotropinomas

Gomes Leonor , Prazeres Hugo , Paiva Isabel , Ribeiro Cristina , Rebelo Olinda , Martins Teresa , Lacerda Manuela , Carvalheiro Manuela

Objective: The pathogenesis of pituitary tumours is still incompletely understood. Somatotropinomas occur both sporadically and in the context of familial syndromes, such as multiple endocrine neoplasia type 1 (MEN1), Carney complex (CNC) and isolated familial somatotropinoma (IFS). Recently, germline mutations were reported in AIP (aryl hydrocarbon receptor interacting protein) gene in Finish and Italian families and in Finish patients with apparently sporadic pituitar...

ea0020p216 | Endocrine tumours and neoplasia | ECE2009

Insulinomas: experience of Coimbra’s University Hospital, Endocrinology Department

Santos Jacinta , Paiva Isabel , Martinho Mariana , Vieira Alexandra , Carvalheiro Manuela

Background: Insulinomas are rare neuroendocrine tumours (4 cases/million patients per year), representing an important cause of hyperinsulinemia. Usually are benign and sporadic, but can be part of multiple endocrine neoplasias. To establish the diagnosis it is essential to document inappropriately high levels of insulin during episodes of hypoglycaemia.Aim: Retrospective analysis of the clinical files of the patients followed in our department since Jan...

ea0016p298 | Endocrine tumours | ECE2008

Cyclic Cushing disease: clinical case

Santos Jacinta , Baptista Carla , Paiva Isabel , Rito Manuel , Carvalheiro Manuela

Cyclic Cushing’s disease is a rare situation due to episodic hypersecretion of ACTH. Suspicion is raised when strong clinical stigmata occur, with normal basal values of cortisol and normal responses to dynamic tests. After performing several tests, particularly during phases without symptoms (well-being), the probability of successful diagnosis increases.We describe the case of a 33 years old female patient with full-blown clinical picture (weight ...

ea0016p523 | Obesity | ECE2008

Obesity in GDM: a registry of GDM in Portugal

Ruas Luisa , Paiva Sandra , Rocha Tiago , Dores Jorge , Carvalheiro Manuela

Introduction: A retrospective study of the year 2003, of 1314 women with GDM, from 24 public health Centres in Portugal, was performed.Patients and methods: Women were divided into two groups according to their pre-pregnancy BMI: group Go – BMI ≥30 kg/m2 and group Gno BMI <30 kg/m2. The mean age of these women was 32.9±5 years (18–45), the A1c was <6% in both groups. The influence of the BMI in different...

ea0014p254 | (1) | ECE2007

A registry of GDM in portugal

Ruas Luísa , Rocha Tiago , Dores Jorge , Carvalheiro Manuela

Introduction: A retrospective study of the year 2003, of 1314 women with GDM, was performed.Patients and methods: Two groups according to pre-pregnancy BMI: Go - BMI&gE;30 Kg/m2; Gno BMI<30 Kg/m2. Mean age 32.9±5 years, A1c<6% in both groups. Influence of BMI in different variables was analysed: family history of DM, weight gain during pregnancy; blood pressure, need of insulin, gestation age at the beginning of insulin...

ea0032p420 | Diabetes | ECE2013

Relationship between metformin treatment and hyperlactacidemia diagnosed at the emergency room

Guelho Daniela , Paiva Isabel , Fonseca Isabel , Gouveia Sofia , Saraiva Joana , Moreno Carolina , Carvalheiro Manuela , Carrilho Francisco

Introduction: Renal function and glucose lowering therapy, particularly metformin, influence serum lactate concentration in patients with type 2 diabetes (T2D). However, seems to be an acute precipitating event that triggers hyperlactacidemia and metabolic acidosis. This study aims to assess prevalence of hyperlactacidemia in T2D patients who presented at emergency room (ER), calculate relative risk of hyperlactacidemia in diabetics under metformin, identify predictive factors...

ea0026p302 | Obesity | ECE2011

Obesity in GDM

Ruas Luisa , Alves Marcia , Paiva Sandra , Marta Elvira , Lobo Antonio , Moura Paulo , Carvalheiro Manuela

Introduction: Retrospective study, 2003–07, of 619 GDM women.Patients and methods: Two groups according to pre-pregnancy BMI: Go ≥30, Gno <30 kg/m2. Influence of BMI in: family history of DM, previous GDM or macrossomia, gestational age at time of GDM diagnosis, weight gain, blood pressure, A1c, need and doses of Insulin, time and type of delivery, new- born weight, complications and re-evaluation post partum.<p class="abste...

ea0022p90 | Bone/Calcium | ECE2010

Primary hyperparathyroidism: retrospective evaluation

Santos Jacinta , Paiva Isabel , Barros Luisa , Vieira Alexandra , Alves Marcia , Gouveia Sofia , Carvalheiro Manuela

Introduction: Primary hyperparathyroidism (PHP) results from an excessive secretion of parathyroid hormone (PTH), typically leading to hypercalcaemia. This disorder is more common than previously expected, since it is frequently diagnosed in asymptomatic patients.Objectives: To characterize a group of patients with PHP, in what concerns to: age, clinical presentation, biochemical and imaging evaluation, treatment and evolution.Pati...

ea0022p101 | Bone/Calcium | ECE2010

Fine needle aspiration of parathyroid gland with PTH analysis in washouts: is it worthy?

Melo Miguel , Ribeiro Cristina , Paiva Sandra , Vieira Alexandra , Carrilho Francisco , Carvalheiro Manuela

Introduction: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcaemia in the outpatient setting. Surgical remove of an adenoma or hyperplastic glands results in cure, but an accurate localization, preoperative whenever possible, is essential for success. Taking into consideration that parathyroid carcinoma is a rare event, FNA of parathyroid glands, complemented by PTH measurement in washouts (FNA/PTH), may be a useful tool in the diagnostic workout.<...

ea0020p1 | Adrenal | ECE2009

Hematoma: unusual presentation of adrenal masses

Vieira Alexandra , Baptista Carla , Paiva Isabel , Barros Luisa , Santos Jacinta , Martinho Mariana , Carrilho Francisco , Carvalheiro Manuela

Introduction: Adrenal hematomas are very rare entities. They occur often associated with: trauma, anticoagulation, coagulopathy, septicemia, pregnancy complications or tumors. When none of these predisposing factors is present, diagnosis and treatment can become a real challenge.Case report: A 19-years-old woman presented with complaints of asteny, loss of appetite, loss of 10 kg in a month, and pain in right lumbar and abdominal regions. No other compla...