Searchable abstracts of presentations at key conferences in endocrinology

ea0032p500 | Endocrine disruptors | ECE2013

Sex hormone-induced gender differences in vascular muscle cells motility are susceptible to the environmental disruptors

Pellegrini Marco , Marino Maria

Sex steroid hormone-induced variations of vascular smooth muscle cells (VSMCs) migration are critical in determining the sex/gender-related differences in male and female pathophysiology of cardiovascular system. Although several substances present in the environment, defined endocrine disruptors (EDs), could interfere with androgen and estrogen effects, the sex/gender-related susceptibility of VSMC motility to these substances is completely unknown. Here, naringenin (Nar) and...

ea0014p495 | (1) | ECE2007

Neonatal ventricular septal defect and late diagnosis of Turner syndrome

Lio Serafino , Cibin Marino

The high morbidity and mortality rate of women with Turner syndrome (TS) is primarily a results of the cardiovascular complications and so it is necessary an accurate and precocious diagnosis of this disease. Congenital cardiac anomalies, whose causes remains unknown, are common in TS (21–40%), in particular among patients with 45 X; between these the ventricular septal defect (VSD) is very rare (in a recent review, 3/1092 cases) (Gravholt 2004) and so in neonatal with VS...

ea0032p693 | Neuroendocrinology | ECE2013

Neuroprotective effects of estrogen rely on neuroglobin upregulation

Fiocchetti Marco , Ascenzi Paolo , Marino Maria

Estrogens, in particular 17β-estradiol (E2), orchestrate cellular mechanisms involved in the development and differentiation of various neuron populations, modulation of synaptic plasticity, induction of neuronal survival, and neurogenesis. Beneficial effects of E2 have been widely reported against a variety of insults, including H2O2 injury, serum deprivation, and glutamate excitotoxicity. Recently, we identified E2 ...

ea0049gp245 | Thyroid Cancer & Thyroid Case Reports | ECE2017

A statistical, in silico model predicts polygenic thyroid cancer risk

Casarini Livio , Marino Marco , Nuzzo Federico , Simoni Manuela , Brigante Giulia

Introduction: The detection of a unique genetic marker is not possible for multifactorial diseases, such as thyroid cancer (TC), where the pathological phenotype is given by the contribution of multiple genes, environmental factors and lifestyle. We found a mathematical model for inferring the risk of thyroid cancer, an example of multifactorial disease.Methods: Genetic data represented by 184 SNPs associated to thyroid tumors were used for Bayesian clus...

ea0049ep1131 | Female Reproduction | ECE2017

The regulation of LHCGR-dependent signaling is linked to circadian gene expression

Gilioli Lisa , Marino Marco , Simoni Manuela , Casarini Livio

Introduction: Reproduction exhibit a regular cyclicity and is regulated by complex interactions between circadian signals, gonadotropins and sex steroid hormones. Peripheral circadian rhythm is generated upon cyclic transcription of clock genes expressed in several cells, e.g. granulosa cells in the ovary. Here we investigated whether cyclic intracellular events occurring in response to gonadotropins are linked to expression of clock genes.Methods: Prima...

ea0032p720 | Nuclear receptors and signal transduction | ECE2013

Coordination of 17β-estradiol-dependent cell proliferation requires diverse post-translational modifications

La Rosa Piergiorgio , Pesiri Valeria , Marino Maria , Acconcia Filippo

The sex hormone 17β-estradiol (E2) exerts its pleiotropic effects through the binding to the ligand-activated transcription factor estrogen receptor alpha (ERa). The E2:ERa complex regulates several physiological processes including cell survival and proliferation through transcriptional (i.e., estrogen responsive element (ERE)-based gene transcription) and non-transcriptional membrane-initiated effects (i.e., activation of signalling cascades).Many...

ea0056p1028 | Thyroid (non-cancer) | ECE2018

IgM thyroglobulin autoantibodies are detectable in serum of patients with subacute thyroiditis

Brancatella Alessandro , Ricci Debora , Marino Michele , Vitti Paolo , Latrofa Francesco

Context: Subacute thyroiditis (SAT) is an inflammation of the thyroid, likely caused by a viral infection. IgG Autoantibodies (Ab) to the main thyroid antigens, including thyroglobulin (Tg) (TgAb) have been reported in a few patients with SAT and their appearance is usually transient. We investigated whether IgM TgAb can be detected in sera of patients with SAT.Design: Serum samples were collected from 17 patients with SAT, ten with Graves’ disease ...

ea0081p98 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

VLCKD: a real time safety study in obesity

Verde Ludovica , Barrea Luigi , Vetrani Claudia , Marino Francesca , Aprano Sara , Savastano Silvia , Colao Annamaria , Muscogiuri Giovanna

Very Low-Calorie Ketogenic Diet (VLCKD) is currently a promising approach for the treatment of obesity. However, little is known about the side effects since most of the studies reporting them were carried out in normal weight subjects following ketogenic diet for other purposes than obesity. Thus, the aims of the study were: 1) to investigate the safety of VLCKD in subjects with obesity; 2) if VLCKD-related side effects could have an impact on its efficacy. In this prospectiv...

ea0084op-10-47 | Oral Session 10: Young Investigators / Clinical and Translational | ETA2022

Putative protective role of anti-nuclear antibodies in graves’ orbitopathy

Lanzolla Giulia , Comi Simone , Puccinelli Lisa , Menconi Francesca , Marcocci Claudio , Marino' Michele

Objectives: A sporadic association between thyroid and non-organ-specific autoimmunity has been reported, which could be relevant for Graves’ orbitopathy (GO), an autoimmune disease affecting orbital connective tissue. We investigated whether there is an association between GO and anti-nuclear antibodies (ANAs).Methods: We performed a cross-sectional investigation in 265 consecutive patients with Graves’ disease (GD) who came to our observation...