Searchable abstracts of presentations at key conferences in endocrinology

ea0063p620 | Diabetes, Obesity and Metabolism 2 | ECE2019

Next generation sequencing reveals ABCC8 (MODY 12) variants in two families with diabetes mellitus (DM)

Markou Athina , Sertedaki Amalia , Tatsi Elizabeth , Piaditis George , Kounadi Theodora , Kanaka-Gantenbein Christina

Introduction: Maturity Onset Diabetes of the Young (MODY) constitutes a genetically and clinically heterogeneous type of Monogenic Diabetes (MD). It is characterized by autosomal dominant inheritance, early onset diabetes, defect in the β-cell insulin secretion, positive family history, absence of diabetic ketoacidosis, auto-antibodies and insulin resistance. To date, 14 different MODY subtypes have been reported each one with distinct genetic etiology, however MODY patie...

ea0035p475 | Diabetes therapy | ECE2014

Improvement of HbA1c is blunted following discontinuation of an on-line telemonitoring system, in patients with inefficiently controlled insulin-treated diabetes mellitus

Fountoulakis Stelios , Papanastasiou Labrini , Malliopoulos Dimosthenis , Marakaki Chrisanthi , Markou Athina , Kounadi Theodora , Piaditis George

Aim: Primary goal was to determine whether the improvement of HbA1c, observed in inefficiently insulin-treated diabetes mellitus (DM) patients on a telemonitoring system, had a lasting effect following its discontinuation.Methods: Forty-seven DM patients (mean age 56.15±15.86 years, mean BMI 29.44±6.69 kg/m2, mean HbA1c 9.9±2.62%) and 25 insulin-treated matched controls (mean age 56.16±20.11 years, mean BMI 27.6±5.18 k...

ea0070aep360 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Arare case of caucasian patient with insulin autoimmune syndrome induced by a-lipoic acid

Glikofridi Spyridoula , Papanastasiou Labrini , Markou Athina , Andrianesis Vasileios , Gravvanis Christos , Kounadi Theodora

Introduction: Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia caused by insulin autoantibodies (IA) in the absence of exogenous insulin administration. The occurrence of IAS may be influenced by a genetic predisposition determined by HLA class II. IAS is frequently reported in Japanese and Koreans due to their genetic predisposition (HLA-DRB1*0406) rather than in the Caucasians. Some drugs containing sulfhydryl compounds are known to initiate the...

ea0020p448 | Obesity and Metabolism | ECE2009

Evidence of increased cardiovascular risk in patients with non-secreting unilateral adrenocortical adenomas

Androulakis Ioannis , Kollias George , Markou Athina , Papanastasiou Lambrini , Angnostou Tilemachos , Papamichael Christos , Piaditis George , Kaltsas Gregory

Background: Incidentally discovered adrenal adenomas (AA) are associated with increased prevalence of hypertension, obesity, and impaired glucose tolerance, all established risk factors for cardiovascular (CV) morbidity. However, most studies were performed in patients with AA and autonomous cortsisol and/or aldosterone secretion, whereas the presence of cardiovascular risk in patients with non-secreting AA has not been looked into detail.Methods: Cardio...

ea0081p522 | Adrenal and Cardiovascular Endocrinology | ECE2022

Gastric monomorphic epitheliotropic intestinal T-cell lymphoma with bilateral adrenal metastases

Kaliakatsou Eirini , Markou Athina , Papanastasiou Labrini , Giagourta Irini , Kalantzi Athanasia , Dimitriadi Anastasia , Lenos Michael , Kounadi Theodora , Fountas Athanasios

Introduction: Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), formerly known as type II enteropathy-associated T-cell lymphoma, is a rare and aggressive subtype of lymphoma of the gastrointestinal track typically noted in Asian or Hispanic populations. Adrenal involvement as part of MEITL is extremely rare. Herein we present a patient of Greek origin with MEITL and bilateral adrenal metastases.Case Presentation: A 74-year-old man presente...

ea0063p91 | Calcium and Bone 1 | ECE2019

Effectiveness of intramuscular Ergocalciferol treatment in a patient with o steomalaciadueto severe vitamin D deficiencyafterbariatric surgery

Papanastasiou Labrini , Gravvanis Christos , Tournis Symeon , Markou Athina , Kalantzi Athanasia , Zoulias Manolis , Georgakopoulou Georgia , Pagoni Stamatina , Kounadi Theodora

Bariatric surgery is a common treatment for morbidly obese patients requiring weight loss and/or metabolic control. Vitamin D (VitD) deficiency and bone loss may occur post-operatively and supplementation with high oral doses of Vitamin D is required. Alternatively, intramuscular depot ergocalciferol (vitamin D2) which slowly releases VitD and overcomes the gastrointestinal tract, could be administrated in such patients.Aim: To present a case of severe V...

ea0041gp23 | Adrenal (2) | ECE2016

Deterioration of indices of insulin resistance in patients with non-functioning and cortisol secreting adrenal incidentalomas during a long term follow-up

Papanastasiou Labrini , Alexandraki Krystallenia , Fountoulakis Stelios , Kounadi Theodora , Markou Athina , Tsiavos Vaios , Androulakis Ioannis , Samara Christianna , Piaditis George , Kaltsas Gregory

Introduction: Adrenal incidentalomas (AI) with or without concomitant autonomous cortisol secretion can be associated with several metabolic alterations that may lead to increased cardiovascular risk. However, data regarding insulin resistance (IR) during long term follow-up of AI are scarce. The aim was to prospectively investigate the presence and evolution of IR in patients with AI between 2003 and 2014.Methods: Seventy three patients with AI for at l...

ea0070aep63 | Adrenal and Cardiovascular Endocrinology | ECE2020

Surgical outcomes of adrenalectomy for primary hyperaldosteronism after using novel diagnostic tests

Alexandraki Krystallenia , Markou Athina , Papanastasiou Labrini , Tyfoxylou Ernestini , Kapsali Chara , Gravvanis Christos , Kaltsas Gregory , Zografos Giorgos , Piaditis George

Background: Primary hyperaldosteronism (PHA) is the most frequent type of endocrine hypertension with a prevalence that is continuously rising. Following the introduction of diagnostic tests that consider both the adrenocorticotropic hormone effect andrenin–angiotensin–aldosterone system (RAAS), the post-dexamethasone saline infusion test (D-SIT) and the overnight dexamethasone, captopril, valsartan test (DCVT) using pharmaceutical RAAS blockade, a higher prevalenc...

ea0022p378 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Identification of a novel mutation of MEN1 gene in a patient with persisting primary hyperparathyroidism

Papanastasiou Labrini , Prevoli Anastasia , Pappa Theodora , Kamakari Smaragda , Kafritsa Paraskevi , Metaxa-Mariatou Vassiliki , Markou Athina , Piaditis George

Background: Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant disorder characterized by the presence of endocrine and nonendocrine tumors. Until recently, more than 450 different germline mutations have been reported in MEN1 patients involving frameshift deletions, insertions, as well as nonsense mutations.Aim: To report a novel mutation in MEN1 gene in a young female with persisting primary hyperparathyroidism.<p class="ab...

ea0016p39 | Adrenal | ECE2008

Impaired endothelial morphology and function in patients with subclinical Cushing's syndrome due to single adrenocortical adenomas

Androulakis Ioannis , Kollias Georgios , Markou Athina , Gouli Aggeliki , Anagnostou Tilemachos , Stamatelopoulos Kimon , Papamichael Christos , Piaditis Georgios , Kaltsas Gregory

Background: Subclinical Cushing’s syndrome (SCS) due to incidentally discovered adrenal adenomas (AI) has been associated with increased prevalence of hypertension, obesity, and impaired glucose tolerance which are established risk factors for cardiovascular morbidity. Although functional and morphological (structural) changes of endothelium have been correlated with cardiovascular morbidity this has not been looked into detail in patients with adrenal incidentalomas....