Endocrine Abstracts

Introduction: Hypertension is a very common chronic disease worldwide. Its imbalance is one of the main causes of cardiovascular and neurodegenerative complications.Patients and Methods: We collected data from hypertensive patients who voluntarily presented for screening on both diabetes and hypertension screening days.Poor blood pressure control was defined as systolic blood pressure (SBP) greater than or equal to 140 mmHg and/or diastolic blood pressur...

We aimed to identify causal mutation(s) in 13 patients with thyroid dyshormonogenesis (TD) from three consanguineous Tunisian families. A 12-year clinical follow-up showed phenotypic variability ranging from the presence to the absence of goiter, sensorineural deafness, and mental retardation. Genetic analysis using microsatellite markers within two candidate genes (TPO and PDS) gave evidence of linkage with the TPO gene. Sequencing of its 17 exons and their flanking intron-ex...

Introduction: Anemia is defined by the World Health Organization as a hemoglobin concentration less than 120 g/l in women outside of pregnancy, and less than 130 g/l in men over 15 years of age. It is common in diabetics. It can be due to an autoimmune disease associated with type 1 diabetes, whereas the inflammatory cause is the primary cause in type 2 diabetes.Observation: This is a 75 year old patient, type 2 diabetic for 21 years on insulin analogues...

Intoduction: Pitiutary tumor is considered as the first etiology responsable of secondary hypopituitarism. Hypogonadotropic hypogonadism is the most commonly reported lesion.Meterials and methods: It is a retrospective study including 77 cases of prolactinoma. The data collection was done over 17 years, between 2000 and 2017.Results: Gonadotropic deficiency was confirmed in 48 patients (63.6%). A significant negative correlation wa...

Introduction: Subclinical Cushing’s syndrome refers to autonomous cortisol secretion in patients who do not have the typical signs and symptoms of hypercortisolism. This study was undertaken to describe clinical, biological and radiological features of this disease and to evaluate the clinical outcome after surgical and medical treatment.Methods: Retrospective study conducted over a period of 12 years and including 17 patients hospitalised in our de...

Introduction: Diabetic foot infection (DFI) is a major public health problem, both for its morbid clinical consequences mainly ulcers and the economic social cost due to repeated hospitalisations and the high rate of amputation.Objectives: Analyse the clinical presentation of DFI, study risk factors of developing this infection and describe the therapeutic management.Materials and methods: Retrospective study spread over 8 years ol...

IntroductionThe association of type 1 diabetes with other autoimmune diseases is well known due to a common genetic terrain of varied clinical expressions. However, the occurrence of systemic diseases in diabetic patient, whatever the type of diabetes, is poorly studied. The objective of this study is to describe autoimmune and inflammatory diseases associated with diabetes.Materials and methodsIt ’ s a ...

IntroductionNon-functioning pituitary adenomas (NFPA) present approximately 15% to 30% of all pituitary adenomas. They are most commonly misdiagnosed, until they are large enough to lead to mass effect and hypopituitrasm. The present study was carried out with the aim of studying the clinical and biological characteristics of patients who are followed for NFA.Patients and methodsThis is a retrospective study ...

Introduction: Congenital adrenal hyperplasia (CAH) in its classical form is an early-onset and challenging-to-treat condition with long-term evolution associated with significant morbidity, typically involving metabolism, bone, and gonadal aspects. Through this specific case study, we illustrate one of the rare complications of CAH in adulthood.Case Report: A 24-year-old patient, born of consanguineous parents, has been monitored since birth for classica...

Introduction: Obesity is recognized as a risk factor for cardiovascular diseases. She can be associated with cardio-metabolic diseases. The objective of our study was to determine the metabolic profile of our obese adults.Materials and methods: This is a descriptive cross-sectional study involving obese adults consulting the service of Endocrinology of Sfax, Hedi Chaker University Hospital in 2023.Results: We recruited 40 obese pat...