Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep289 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Association of nutritional support with in-hospital mortality in malnourished medical inpatients – a population-based cohort study

Kutz Alexander , Nina Kaegi-Braun , Marlena Mueller , Beat Mueller , Philipp Schuetz

Background: Malnutrition has been associated with increased adverse clinical outcomes and affects a considerable proportion of hospitalized medical patients. While recent evidence from clinical trials revealed a survival benefit from nutritional support, data from a large real-world population is still missing.Methods: In this population-based cohort study, using a Swiss administrative claims database from January 2012 to December 2017, we created a medi...

ea0063gp257 | Thyroid Nodules and Cancer 2 | ECE2019

Effects of hospital volume on clinical outcomes after thyroidectomy - a Swiss nation-wide study

Ebrahimi Fahim , Kutz Alexander , Christ Emanuel , Schuetz Philipp , Mueller Beat

Background: Epidemiologocal data suggest an continuous increase in thyroid carcinoma diagnosis. Therefore, thyroidectomy rates are projected to increase world-wide in exponential scale. In Switzerland, the institutional number of thyroidectomies varies, however there is no data yet on the association between institutional thyroidectomy volume and clinical outcome.Methods: Cross-sectional analysis of adult inpatients in Swiss hospitals using a nation-wide...

ea0063p797 | Thyroid 2 | ECE2019

Gender-specific variations of clinical outcomes after thyroidectomy

Kutz Alexander , Ebrahimi Fahim , Christ Emanuel , Schuetz Philipp , Mueller Beat

Background: Incidence of thyroidectomies and awareness to postoperative quality measures have both increased in the last decade. Gender-specific indications and variations in clinical outcomes of patients undergoing thyroidectomy in Switzerland are of interest.Methods: We cross-sectionally compared administrative nationwide patient-level data for length of hospital stay (LOS), intensive care unit (ICU) admission, 30-day readmissions rates, and other qual...

ea0020p28 | Adrenal | ECE2009

Prior dexamethasone suppression test predicts development of adrenal insufficiency after a 14 days’ course of oral prednisone in healthy male volunteers

Neidert Stefanie , Schuetz Philipp , Mueller Beat , Christ-Crain Mirjam

Background: Neither dosage nor duration of systemic glucocorticoid therapy are reliable indicators of subsequent adrenal insufficiency. The dexamethasone suppression test is a measure of feedback sensitivity of the hypothalamic–pituitary–adrenal axis to cortisol. We hypothesized that this test predicts the later development of an adrenal insufficiency after a 14 days’ course of oral prednisone in healthy volunteers.Methods: We analyzed dat...

ea0063oc5.5 | Adrenal 1 | ECE2019

Impact of adrenal insufficiency on patient-centred health care outcomes in adult medical inpatients

Widmer Andrea , Ebrahimi Fahim , Wagner Ulrich , Mueller Beat , Schuetz Philipp , Christ-Crain Mirjam , Kutz Alexander

Background: Patients with adrenal insufficiency suffer from increased morbidity and mortality. Quantitative evidence on the health-care burden of either primary (PAI) or secondary adrenal insufficiency (SAI) among hospitalized medical patients is scarce.Methods: In this observational cohort study, we analysed nationwide acute care hospitalizations from patients with PAI or SAI, respectively, between 2011 and 2015 using prospective administrative data. Pa...

ea0063p1013 | Interdisciplinary Endocrinology 2 | ECE2019

Burden of hyponatremia on clinical outcomes in hospitalized adult medical inpatients

Kutz Alexander , Ebrahimi Fahim , Aghlmandi Soheila , Wagner Ulrich , Schuetz Philipp , Mueller Beat , Christ-Crain Mirjam

Background: Hyponatremia is the most prevalent electrolyte disorder in hospitalized adult medical patients and is associated with a significant healthcare resource burden. However, evidence remains scarce whether hyponatremia is a marker of disease severity or whether it has an independent effect on clinical outcomes.Methods: In this nationwide cohort study, we analyzed medical inpatients with hyponatremia diagnosed between January 2009 through December ...

ea0049ep687 | Obesity | ECE2017

Effects of IL-1β on the hypothalamic-pituitary-gonadal axis in men with obesity and metabolic syndrome – A randomized, double-blind, placebo-controlled trial

Ebrahimi Fahim , Schuetz Philipp , Mueller Beat , Urwyler Sandrine A , Donath Marc Y , Christ-Crain Mirjam

Background: Low testosterone levels in men appear to be an independent cardiovascular risk factor closely associated with the metabolic syndrome. Reciprocally, the metabolic syndrome leads to a decrease in testosterone levels, suggesting a bidirectional relationship. It has been hypothesized that increased inflammation is causative for the development of obesity-associated hypogonadism. However, clinical evidence supporting this hypothesis is lacking. The aim of the present st...

ea0020oc3.6 | Reproduction/Stress/Endocrine Disruptors | ECE2009

Cortisol as a prognostic marker of outcome in acute ischemic cerebrovascular events

Neidert Stefanie , Katan Mira , Fluri Felix , Morgenthaler Nils , Schuetz Philipp , Mueller Beat , Christ-Crain Mirjam

Background: Stroke is the second commonest reason of mortality worldwide and a major cause of long term disability. Early prediction of outcome is important for allocation of therapeutic strategies. Endocrine alterations of the hypothalamus–pituitary–axis (HPA) are one of the first stress-induced alterations after cerebral ischemia. We evaluated the prognostic value of cortisol for outcome in acute ischemic cerebrovascular events.Method: In an ...

ea0063gp44 | Metabolic Syndrome and Hypoglycaemia | ECE2019

Effects of anti-inflammatory treatment on fibroblast growth factor-21 in obesity and metabolic syndrome

Ebrahimi Fahim , Urwyler Sandrine , Betz Matthias , Christ Emanuel , Schuetz Philipp , Mueller Beat , Donath Marc , Mirjam Christ-Crain

Background: Fibroblast growth factor-21 (FGF21), which has recently been identified as a central regulator of metabolism, is known to be increased in conditions of obesity, insulin resistance, and fatty liver. Likewise, there is evidence that FGF21 increases with systemic inflammation. The aim of this study was to evaluate whether chronic low-grade inflammation might be the underlying mechanism and whether an anti-inflammatory treatment decreases FGF21 levels in metabolic diso...

ea0063gp133 | Obesity | ECE2019

Effect of IL1-receptor antagonist on renin-angiotensin-aldosterone system and hemodynamics in obese individuals

Urwyler Sandrine , Ebrahimi Fahim , Burkard Thilo , Schuetz Philipp , Poglitsch Marko , Beat Mueller , Donath Marc Y , Christ-Crain Mirjam

Background: Interleukin (IL)-1 antagonism decreases systolic blood pressure in obese individuals. However, the underlying mechanism is unknown. Based on experimental data in animals we hypothesised a blood-pressure lowering effect of IL-1-antagonism via modulation of the renin-angiotensin-aldosterone system (RAAS).Methods: In this post-hoc explorative study, we examined short- (2 days) and long-term effects (4 weeks) of IL-1 antagonism (anakinra/Kineret<...