Endocrine Abstracts

Introduction: Sensitive neuropathy is a degenerative complication of diabetes, precipitated by chronic glycemic imbalance. It is estimated that it is present in 50% of diabetics, and that it requires treatment in 10 to 20% of cases.This study aimedto assess the prevalence of sensitive neuropathy and to identify the factors associated with it in a population of patients with diabetes.Patients and Methods: This is a descriptive and a...

Aims: To assess the knowledge of diabetic patients on the health of their feetand to identify the associated factors with good knowledge, while providing podiatric advice.Methodology: It was a descriptive and analytical transversal prospective studyabout 100 diabetic patients (44 men, 56 women; age range 29–87 years). They had an evaluation of their knowledge on the diabetic foot, using a pre-established questionnaire as well as a metabolic evaluat...

Introduction: The American Diabetes Association (ADA) recommends an annual foot screening of patients podiatric risk for ulceration and amputation, to take effective preventive measures. However, the gradation of the podiatric risk remains insufficient, particularly in Tunisia, where epidemiological references remain missing. The aim of this study was to classify a population of diabetic patients according to the grade of podiatric risk by referring to the recommendations of t...

Introduction: Autotaxin (ATX)[Ectonucleotide Pyrophosphatase /Phosphodiesterase family member 2 (ENPP2)] is a lysophospholipase D stimulating cell migration, metastasis and angiogenesis. ATX hydrolizes lysophosphatidylcholine (LPC) and produces bioactive lysophosphatidic acid(LPA). There are some clues about ATX–LPA pathway modulation may unlock the gate of metabolic derangement including diabetes formation or may impact formation of cardiovascular diseases via LPA’s...

The study presents the outcome of determination of serum VEGF and sVCAM in 58 patients (43 women and 15 men aged 20–76 years) with adrenal tumors: adrenal cortical adenoma (34), adrenal cortical carcinoma (12), pheochromocytoma (9), myelolipoma (2) and lymphangioma (1). Control group comprised 25 practically healthy volunteers (13 women and 12 men aged 17–67 years). Serum VEGF was measured by enzyme immunoassay using reactants from ‘R&D’ (USA), sVCAM &#...

Objective: C-reactive protein (CRP) is a nontraditional risk factor that predicts cardiovascular disease but its relationship between diabetes and insulin resistance is not well documented. We evaluated the association of CRP levels and insulin resistance in a group of patients at high risk for diabetes.Materials and methods: In this study we evaluated 22 first degree relatives of type 2 diabetic patients with impaired glucose tolerance test (Group 1) an...

BackgroundPrecise diagnostics for postprandial reactive hypoglycaemic syndrome (PRHS) after gastric bypass surgery (GBS) are lacking. Oral glucose tolerance tests are advocated but might cause early dumping in this population and often cause hypoglycaemic values in a normal population.AimTo evaluate glycaemic responses during liquid and solid mixed meal tolerance tests (LMMTT and SMMTT) in a post-GBS populati...

Introduction: The etiology of gender dysphoria is still unclear. Although prior studies have shown trans men have higher androgen levels than cisgender women, they all concluded unselected populations. Our purpose to perform this study is to evaluate transmen’s hormone profile and metabolic status to compare cisgender women in a more selected population. This is the first case-controlled study to compare anthropometric, metabolic, and endocrinological parameters of drug-n...

Purpose: Thyroid autoimmune diseases occur more frequently in women than men. A previous study reveals that exogenous testosterone may have a protective effect on thyroid autoimmunity in men with Hashimoto’s thyroiditis. But no study has determined whether sex hormones produce any effect on thyroid antibody titreş in women. The primary study aim was to assess whether exogenous testosterone affects thyroid autoimmunity in trans-men with increasing testosterone levels....

Background and aim: The role of derangements of nitric oxide (NO) metabolism in the pathogenesis of complications of type 1 diabetes mellitus (T1D) is not sufficiently clear. There is little data on simultaneous measurements of NO metabolites nitrite and nitrate (NO2/NO3) in urine and serum in T1D. Data about the measurement of NO production by electronparamagnetic spectroscopy (EPR) in whole blood in T1D were never published. To fill this gap we have cha...