Searchable abstracts of presentations at key conferences in endocrinology

ea0063oc6.4 | Obesity | ECE2019

Fat mass impact of sirolimus after clinical islet transplantation, a case control study

Jannin Arnaud , Espiard Stephanie , Hoth-Guechot Helene , Kerr-Conte Julie , Pattou Francois , Vantyghem Marie-Christine

Introduction: Sirolimus, a mTOR (mechanistic Target of Rapamycin) inhibitor, is well known for its impact on glucides and lipids metabolism. These effects vary according to factors such as dose and treatment duration, species, cell types and environmental factors. In vitro and in vivo, sirolimus inhibits adipogenesis by decreasing adipocytes number and size, as well as pre-adipocytes differentiation, leading to subcutaneous and visceral fat mass decrease in m...

ea0037gp.14.05 | Diabetes and obesity – Clinical diabetes | ECE2015

The effect of Roux-en-Y gastric bypass, sleeve gastrectomy and adjustable gastric banding on renal function and remission of metabolic disease: a five-year longitudinal study

Neff Karl , Baud Gregory , Raverdy Violeta , Roux Carel le , Pattou Francois

Introduction: There are few data on renal function following bariatric surgery. We evaluated the effect of Roux-en-Y gastric bypass (RYGB), adjustable gastric banding (AGB) and sleeve gastrectomy (SG) on renal function over a 5-year post-operative period. We also evaluate the effect of these procedures on remission of diabetes and hypertension.Methods: Analysis of a prospectively collected database at Lille University Hospital. Patients were assessed pre...

ea0035oc11.3 | Diabetes and Obesity 2 | ECE2014

Improvement or stabilization of retinopathy and visual acuity after islet transplantation: a 5-year prospective study

Vantyghem Marie-Christine , Quintin Delphine , Labalette Pierre , Kerr-Conte Julie , Pattou Francois

This study describes the evolution of retinopathy 5 years after islet transplantation (IT) with the Edmonton protocol in type 1 diabetic patients. Before IT and then yearly for 5 years, 21 patients (13 islet-alone (ITA), 8 islet-after-kidney (IAK)) underwent monitoring of laboratory parameters, continuous 24 h mean blood pressure (24h BP) and 72 h glucose (CGM), as well as complete ophthalmologic examination. Ten of the 21 patients (48%) were insulin-independent 5 years post-I...

ea0090p536 | Late-Breaking | ECE2023

Role of insulin therapy in weight gain: lessons from islet transplantation in type1 diabetes

Romain Bulois , Jannin Arnaud , Defrance Frederique , Mapihan Kristell Le , Mikael Chetboun , Julie Kerr-Conte , Francois Pattou , Vantyghem Marie-Christine

Background: Weight gain in type 1 diabetes (T1D) patients has become a clinical problem due to less strict diets and more stringent glycemic targets. Thus, the number of overweight T1D in the USA increased from 3.4% in 1988 to 22.7% in 2007. Hyperinsulinism is involved in the genesis of obesity but in T1D, the impact of insulin therapy in weight gain is not established. Islet transplantation, now reimbursed in France, makes it possible to interrupt insulin. The aim of this wor...

ea0041ep6 | Adrenal cortex (to include Cushing's) | ECE2016

Bilateral adrenalectomy is a safe long-term procedure

Coralie Moutarde , Robert Caiazzo , Catherine Bauters , Christine Cortet , Christine Do Cao , Jean-Louis Wemeau , Francois Pattou , Marie-Christine Vantyghem

The aim of this retrospective study was to compare the long-term evolution of adrenal insufficiency (AI) due to bilateral adrenal surgery (S) or medical cause (M).Seventy AI patients (mean age 41±16 years; 60% female, similar in both groups) were followed during a mean 6-year period (2–16); 38 were AI after bilateral adrenalectomy (60% Cushing), 32 AI of medical origin (62% polyglandular autoimmune syndrome). BMI, blood pressure (BP), fasting b...

ea0035p144 | Calcium and Vitamin D metabolism | ECE2014

Recurrent post-surgical hyperparathyroidism: think of CYP 24A1 mutations!

Loyer Camille , Leroy Clara , Huglo Damien , Boury Samuel , Molin Arnaud , Kottler Marie-Laure , Pattou Francois , Vantyghem Marie-Christine

CYP24A1 gene encodes 24-hydroxylase that inactivates 1-25-OHvitaminD. Mutations induce infantile hypercalcemia, with high 1-25-OHvitaminD, contrasting with low PTH levels. Adult phenotypes are not well known yet. We report two cases of post-surgical persistent hypercalcemia, related to CYP24A1 mutations. Two unrelated patients, a 40-year-old female (#1) and 54-year old male (#2), were referred for nephrolithiasis, enthesis and hypertension in both, associated...

ea0032oc6.4 | Diabetes & Obesity | ECE2013

Reduction of fat mass with the mTOR inhibitor, sirolimus, in humans: from transplantation to lipodystrophies

Parent Emilie , Pattou Francois , Ernst Olivier , Lion Georges , Wolowczuk Isabelle , Dharancy Olivier , Noel Christian , Kerr-Conte Julie , Vantyghem Marie-Christine

Objectives: Sirolimus inhibits adipocyte differentiation (Yeh PNAS 1995). This study compares weight and fat markers in two groups of patients treated or not with sirolimus, before and after transplantation.Patients and method: Nineteen islet-alone transplanted patients treated with sirolimus and 7 islet-alone or liver-transplanted patients NOT treated with sirolimus were compared 1 year after transplantation in terms of weight, fat mass (equation of bod...

ea0022p404 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Ectopic insulin secretion from distant metastasis or ectopic metaplasia after total pancreatectomy for ACTH-secreting endocrine pancreatic tumor revealing a Von Hippel Lindau disease

Vantyghem Marie-Christine , Wild Damian , Neraud Barbara , Nghi-Beron Amandine , Raverdy Violeta , Steinling Marc , Wemeau Jean-Louis , Pattou Francois

Von Hippel Lindau disease (VHL) induces tumors of kidneys, central nervous system, pancreas and paragangliomas We report one case where ectopic Cushing syndrome revealed VHL. A 19-year old was referred for hirsutism and spaniomenorrhea revealing an ACTH-dependent Cushing syndrome. Mineralocorticoids, calcium metabolism, chromogranine A, calcitonine, pancreatic hormones and urinary 5-HIA were normal. Blood nor- and metanephrine were 5.12 μg/l (n<5) and 0.92 &#95...

ea0063gp1 | Adrenal and Neuroendocrine - Tumour | ECE2019

68Ga-exendin-4 PET/CT detects insulinomas in patients with hypoglycemia in multiple endocrine neoplasia type 1

Antwi Kwadwo , Nicolas Guillaume , Fanis Melpomeni , Heye Tobias , Pattou Francois , Grossman Ashley , Chanson Philippe , Reubi Jean Claude , Perren Aurel , Gloor Beat , Vogt Deborah , Wild Damian , Christ Emanuel

Context: Surgical intervention is advised in patients with multiple endocrine neoplasia type-1 (MEN-1) with non-functioning pancreatic neuroendocrine tumors (PanNET) and a size ≥20 mm. However, functioning PanNET such as patients with endogenous hyperinsulinemic hypoglycemia (EHH) due to (one or multiple) insulinomas should be treated surgically independent of size. Reliable preoperative localization of insulinomas is critical for surgical strategy.<p class="abstext"...

ea0041oc3.2 | Diabetes prediction &amp; complications | ECE2016

Glucose-dependent insulinotropic peptide (GIP) stimulates Glucagon-like peptide (GLP)-1 from human and mouse pancreatic islets partly via alpha-cell-derived IL-6

Timper Katharina , Dalmas Elise , Dror Erez , Rutti Sabine , Thienel Constanze , Sauter Nadine S. , Bouzakri Karim , Bedat Benoit , Pattou Francois , Kerr-Conte Julie , Boni-Schnetzler Marianne , Donath Marc Y.

Introduction: Glucose-dependent insulinotropic peptide (GIP) induces the cytokine interleukin (IL)-6 in adipocytes. IL-6 enhances insulin secretion from β-cells via L- and α-cell-derived GLP-1.Therefore we hypothesized that GIP regulates Glucagon-like peptide (GLP)-1 as well as glucose control via IL-6.Methods/Design: Basic research study on isolated human and mouse pancreatic islets and FACS-sorted human α-and β-cells that were treat...