Searchable abstracts of presentations at key conferences in endocrinology

ea0020p244 | Bone/Calcium | ECE2009

Effect of one year treatment with strontium ranelate on bone mineral density in women with established osteoporosis previously treated with teriparatide

Anastasilakis Athanasios , Polyzos Stergios , Avramidis Avraam , Papatheodorou Athanasios , Terpos Evagellos

Teriparatide (TPTD – recombinant human parathyroid hormone 1–34) markedly increases bone mineral density (BMD) and reduces fracture risk. Sequential treatment with an antiresorptive agent is believed to preserve or further increase BMD. Strontium ranelate (SR) is thought to uncouple bone remodeling resulting in increased BMD and reduced fracture risk. In this prospective study, we aimed to evaluate the effect of SR on BMD in women with established osteoporosis previo...

ea0056p229 | Calcium & Vitamin D metabolism | ECE2018

Timely and dose assessment of serum parathormone and calcium levels by cinacalcet in patients with primary hyperparathyroidism: an individualized approach

Duntas Leonidas , Tanteles Savvas , Boutsiadis Anastasios , Polyzos Stergios

Objective: To assess the regulation of parathormone (PTH) and serum calcium (s-Ca) in patients, on follow-up over a long time period of four years, who have primary hyperparathyroidism (pHPT) and whose condition is non-operable or who are not willing to undergo surgery.Methods: Initially, 17 patients with documented pHPT were recruited and treated with calcimimetic cinacalcet at a dose calculated according to s-Ca levels (≤11 mg/dl or >11 mg/dl...

ea0063p467 | Calcium and Bone 2 | ECE2019

Discovery of a novel NOTCH2 mutation causing Hajdu Cheney Syndrome in a kindred with remarkable phenotypic diversity

Efstathiadou Zoe , Kostoulas Charilaos , Polyzos Stergios , Kalograni Fani , Tirkalas Sotirios , Adamidou Fotini , Georgiou Ioannis , Kita Marina

Introduction: Hajdu Cheney Syndrome (HCS) is a rare genetic autosomal dominant disorder affecting multiple organ systems, characterized by distinctive facial features, acroosteolysis and severe osteoporosis. In a limited number of cases, the disease appears in association with polycystic kidney disease (PKD) or Crohn’s disease (CD). Splenomegaly has also been reported. Heterozygous gain-of-function mutations in NOTCH2 gene have been confirmed to be the cause of H...

ea0022p58 | Adrenal | ECE2010

Long-term follow-up of patients with adrenal incidentalomas: a single center experience

Anagnostis Panagiotis , Efstathiadou Zoe , Polyzos Stergios , Tsolakidou Konstantina , Litsas Ioannis , Panagiotou Athanasios , Kita Marina

Introduction: Adrenal incidentalomas (AIs) constitute an emerging clinical entity due to the increased use of abdominal imaging for diagnostic purposes.Objective: To investigate the morphological and hormonal alterations of AIs in a cohort of patients, who were followed-up in a single centre.Methods: Sixty-four patients (22 males and 42 females; mean age 61.6±1.2 years), with AIs and follow-up of 3.1±0.4 years (range 0&#1...

ea0016p94 | Bone and calcium | ECE2008

Scintigraphic, biochemical and clinical response to zoledronic acid treatment in patients with Paget's disease of bone

Avramidis Avraam , Polyzos Stergios , Moralidis Efstratios , Arsos Georgios , Efstathiadou Zoe , Karakatsanis Konstantinos , Grollios Georgios , Kita Marina

Introduction: Bisphosponates have long been used with success in the treatment of Paget’s disease of bone (PDB). The aim of this study was to evaluate the early (up to three months) and late (at twelve months) scintigraphic, biochemical and clinical response to a single intravenous infusion of zoledronic acid (ZOL) in patients with PDB serially assessed for one year.Materials and methods: Nine patients with 30 bone lesions due to PDB were prospectiv...

ea0016p678 | Steroid receptors | ECE2008

Association of estrogen receptor alpha and beta gene polymorphisms with sex steroid levels in men

Sakka Christina , Efstathiadou Zoe , Polyzos Stergios , Goutou Maria , Stakias Nikolaos , Koukoulis George

Estrogens play an important role in male physiology. We investigated the possible association of four single nucleotide polymorphisms in estrogen receptor α (ER1) and Estrogen Receptor β (ER2) genes with circulating levels of sex steroids and Sex Hormone Binding Globulin (SHBG) in men.SHBG, total and calculated free testosterone (TT and cal FT), estradiol (E2) and free estradiol (FE2) were determined in a population based cohort of 170 apparent...

ea0070ep562 | Hot topics (including COVID-19) | ECE2020

A comparative evaluation of late effects of Orthodox religious fasting vs time restricted eating on metabolic profiles of overweight adults

Karras Spyridon , Koufakis Theocharis , Adamidou Lilian , Grammatiki Maria , Polyzos Stergios , Karalazou Paraskevi , Thisiadou Katerina , Zebekakis Pantelis , Makedou Kali , Kotsa Kalliopi

Background: Previous research has demonstrated positive effects of Orthodox fasting (OF) and time restricted eating (TRE) on body weight (BW). However, little is known about the late, metabolic effects of the two diets.Methods: 29 overweight adults followed a hypocaloric diet based on OF. A hypocaloric, TRE plan (eating between 08:00 to 16:00 h) was followed by 16 BW-matched participants. Anthropometric, glycemic and inflammation markers and serum lipids...

ea0032p208 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Comparative effects of atorvastatin and rosuvastatin on vitamin D levels, glucose metabolism and systematic inflammation in non-diabetic patients with dyslipidaemia: a prospective randomised open-label study

Anagnostis Panagiotis , Adamidou Fotini , Slavakis Arisitidis , Polyzos Stergios , Panagiotou Athanasios , Selalmatzidou Despina , Karathanasi Eleni , Poulasouchidou Maria , Kita Marina

Introduction: Low levels of 25-hydroxy-vitamin D [25(OH)D] have been recognized as a new cardiovascular disease risk factor. Conflicting data exist regarding the effect of statins on 25(OH)D levels and glucose metabolism.Methods/design: This was an open-label randomized prospective comparative study evaluating the effects of atorvastatin and rosuvastatin at equivalent doses on 25(OH)D levels, glucose homeostasis and systemic inflammation in non-diabetic ...

ea0032p370 | Diabetes | ECE2013

Serum vaspin levels in women with and without gestational diabetes mellitus during pregnancy and postpartum

Gkiomisi Athina , Makedou Kali , Anastasilakis Athanasios , Polyzos Stergios , Kourtis Anargyros , Gerou Spyridon , Gavana Elpida , Dagklis Themistoklis , Rousso David , Giannoulis Charalambos

Although vaspin is regarded an insulin-sensitizing adipokine, its role in gestational diabetes mellitus (GDM) is currently unknown. We aimed to evaluate serum vaspin levels and their correlation with insulin resistance in women with and without GDM. Forty-four women with GDM (GDM Group 20 managed with diet only (GDM-diet) and 24 with diet plus insulin (GDM-insulin)) and 44 age-matched pregnant women with normal glucose tolerance (control group) were studied. Serum glucose, lip...

ea0016p802 | Thyroid | ECE2008

Serum thyrotropin concentration as a biochemical predictor of thyroid malignancy in patients presenting with thyroid nodules

Polyzos Stergios , Kita Marina , Efstathiadou Zoe , Poulakos Pavlos , Slavakis Aristidis , Sofianou Danae , Flaris Nikolaos , Leontsini Maria , Kourtis Anargyros , Avramidis Avraam

Background: Fine-needle aspiration biopsy is the ‘gold standard’ in the preoperative management of thyroid nodules.Aim: The aim of this study was to investigate whether serum TSH is a predictor of thyroid malignancy in patients presenting with thyroid nodules.Subjects and methods: About 565 patients without overt thyroid dysfunction, who presented with palpable thyroid nodule(s) between 1988 and 2004 and underwent at leas...