Endocrine Abstracts

Introduction: Co-production refers to working in partnership with service-users to improve provision of services. Increasing evidence highlights that co-production can improve health care and result in financial savings. Service-users are involved in defining the problem or need, creating the solution, delivering it, and evaluating it. This approach demands longer-term engagement by service-providers but leads to sustainable change. Graphic facilitation is the use of large-sca...

Background: Excess adipose tissue accumulation and obesity are characterised by a chronic, low-grade, systemic inflammation that contributes to obesity-related cardio-metabolic disease. Nestfatin-1 is a neuropeptide derived from the precursor protein nucleobindin-2 (NUCB2), which was initially reported to exert anorexigenic effects. We have previously shown that NUCB2/Nesfatin-1 is highly expressed in human and mouse subcutaneous white adipose tissue (Sc-WAT) and that circulat...

Section 1: Case history: 75 year old female diagnosed with Grade 1 pNET (Ki-67 index 70%) in 2018. Treated with subtotal pancreatectomy but 8 months post-surgery a follow up scan showed new liver metastases, at which point she was commenced on lanreotide. 3 months later she presented with an 8 week history of episodic weakness, sweating and confusion consistent with hypoglycaemia. These episodes initially improved with eating but had become more severe and unresponsive to carb...

Introduction: Recent randomised controlled trials have demonstrated the efficacy of very low calorie diets (VLCD) in carefully selected patients with type 2 diabetes mellitus (T2DM). However, there is paucity of evidence regarding the efficacy of VLCD in the real-world setting. We evaluated outcomes in obese T2DM patients who underwent VLCD at our institution.Methods: This retrospective observational study included all patients who had undergone VLCD fro...

Introduction: Insulinoma is a rare tumor of the beta cells of the pancreas. The clinical manifestation is diverse with hypoglycemia and autonomic neurological symptoms. For diagnosis the Whipple’s triad needs to be present: signs of hypoglycemia, glucose level under 3 mmol/l and the cessation of symptoms after administration of iv. glucose. The fasting test confirms the diagnosis. The most commonly used imaging techniques that may localize the tumor are the abdominal ult...

Neonatal Cushing syndrome (CS) is a rather rare disease. The majority of these few cases are of ACTH dependent origin or caused by a unilateral adrenal tumour (carcinoma or adenoma), however ACTH independent bilateral hyperplasias stand for only a few percent of all cases. The management of neonatal CS depends on the underlying cause – if found in time - of the disease. In the past the survival rate of children with CS was low, new and renewed medical attempts have improv...

Introduction: Factitious thyrotoxicosis is caused by intentional and surreptitious ingestion of thyroid hormone and can be a challenge in the differential diagnosis with other pathologies.Case report: Female, 35 years old, referred to our department for suspected subacute thyroiditis after COVID-19. The patient had previous medical history of hysterectomy, bilateral oophorectomy, 2 galactophorectomies with right breast reconstruction, depressive syndrome...

Background: Septo-optic dysplasia (SOD), also known as de-Morsier syndrome, is a rare congenital disorder characterized by any combination of optic nerve hypoplasia, pituitary dysfunction and midline abnormalities of the brain. Clinical diagnosis requires the presence of at least two of the features. This disorder is equally prevalent in males and females, with a reported incidence of 1/10,000 live births. There is wide variation in the severity of the clinical features found....

Introduction: Multiple endocrine neoplasia (MEN) is a rare genetic syndrome characterized by occurrence of tumors involving two or more endocrine glands. Four types are described: MEN1, MEN2, MEN3 and the recently identi&#-1279;ed MEN4. Due to the complexity of the syndromes, it is difficult to manage these patients. Our objective was to describe the clinical features of individuals from 7 families with a diagnosis of MEN1 or MEN2 and identify current challenges in clinical pr...

Introduction: In the area of Immunotherapy, immunological checkpoints, such as CTLA-4, PD-1 or PD-L1, are membrane proteins involved in the immune response that, when inhibited, cause an increase in T cell activity and a consequent anti-tumor effect. However, this inhibition can also cause adverse effects, including endocrinopathies, such as thyroid dysfunction and hypophysitis.Clinical case: 59-year-old man, diagnosed with lung cancer, treated with nivo...