Endocrine Abstracts

Objective: Cardiovascular diseases are the most common comorbidities in acromegaly. Potential parameters in pathology of cardiovascular comorbidities are changes in levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) as well as body composition parameters.Purpose: The aim of this study was to examine morphological and functional parameters of the cardiovascular system by echocardiography and to assess its relationship with disease acti...

Background: The aim of our study was to asses changes in the cross sectional area (CSA) of the median nerve by ultrasound in newly diagnosed acromegalic patients 1 year after treatment of acromegaly (transsphenoidal surgery, somatostatine analogues).Patients and methods: The study included 30 newly diagnosed acromegalic patients (18 females and 12 males) and 30 healthy controls (18 females and 12 males) matched for age, gender and body mass index. Clinic...

Background: If the laboratory results are not compatible with the patient’s clinical symptoms, the presence of possible test interference should be considered. Despite the excellent quality of immunoassays, it is currently estimated that they may be susceptible to several types of interference that may lead to patient misdiagnosis.Case report: In our case report we present a 71-year-old woman with confirmation of macro-adrenocorticotropic hormone (m...

Cushing’s syndrome (CS) is a relatively rare disease characterized by autonomous hypersecretion of cortisol. The incidence of CS is estimated to be equal to 2–3 cases per million inhabitants per year.The incidence of acromegaly is 3–4 patients per 1 000000 per year. The disease is caused by hypersecretion of growth hormone which is mainly caused by benign tumour of the pituitary gland. In our case report we present a 41 - year - old woman suffering from both Cus...

Acromegaly is a rare disease, which is mainly caused by benign tumour of the pituitary gland. Long-term presence of elevated growth hormone (GH) and insulin like growth factor 1 (IGF-1) levels accompanying this disease is associated with rheumatologic, cardiovascular, pulmonary and metabolic complications. Cardiovascular complications of acromegaly include a cardiomyopathy, arterial hypertension, arrhytmias, valvulopathy as well as endothelial dysfunction. Cardiovascular disea...

Acromegaly is a rare disorder usually caused by a benign tumour of the pituitary gland. Long-term presence of elevated growth hormone (GH) and insulin like growth factor I (IGF-I) levels accompanying this disease is associated with complications such as heart failure, cerebrovascular disease, diabetes mellitus, sleep apnoea and arthropathy. Incidence of acromegaly is 3-5 patients per million per year. Klinefelter syndrome is ...

Introduction: Patients with acromegaly, despite normal or even high bone mineral density (BMD), have prevalent vertebral fractures (VFs). HR-pQCT studies in acromegaly have proposed that impaired trabecular bone microarchitecture possibly plays a role in fragility fracture development. As such, we hypothesized that trabecular bone score (TBS) would be low in patients with acromegaly.Aim of the study: To compare BMD and TBS in acromegaly patients with and...

Introduction: Patients suffering from acromegaly, despite normal or even higher bone mineral density (BMD), have prevalent vertebral fractures (VFs). Impaired bone microarchitecture is involved fragility fracture development, but vitamin D status could be involved in this impairment.Aim of the study: Comparison of bone parameters such as BMD, trabecular bone score (TBS) and 3D-SHAPER parameters in acromegaly patients according to level of 25(OH)D3.<p...

Introduction: Acromegaly is associated with higher prevalence of vertebral fractures (VFx) and bone microarchitecture potentially play a role in fracture development. Trabecular bone score (TBS), a novel indicator of bone microstructure could provide additional information.Objectives: Assessment of BMD, TBS and bone turnover markers (BTM) in acromegaly patients in comparison to healthy controls with regard to gender, hypogonadism and disease activity.</p...

Combination of Turner syndrome (TS) and classical congenital adrenal hyperplasia (CAH) is rare worldwide. Incidence of CAH - autosomal recessive disorders characterized by enzyme defect of steroidogenic pathway, of which 90% ocuurs in the CYP21A2 gene coding 21-hydroxylase is 1:10000-16000. Incidencie of Turner syndrome is 1:2500 worldwide. Phenotypically, females with TS may present with a wide spectrum of clinical features. They may exhibit short stature, virilization, prema...