Searchable abstracts of presentations at key conferences in endocrinology

ea0081p732 | Thyroid | ECE2022

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in advanced thyroid cancer (TC) patients; single-center experience

Simeakis George , Paschou Stavroula A. , Alevizaki Maria , Saltiki Katerina

Objectives: Patients suffering from pulmonary or/and neoplastic disease are at higher risk of developing serious illness from SARS-CoV-2. TC patients with lung metastases are classified as high-risk for severe CoV-2 disease. Aim of this study was to investigate SARS-CoV-2 prevalence and severity in this particular subgroup of patients.Methods: Out of 28 patients with metastatic Differentiated Thyroid Cancer (DTC) and 21 patients with met...

ea0067o2 | Oral Presentations | EYES2019

Occurrence of second primary malignancy in medullary thyroid cancer (MTC) patients

Simeakis George , Saltiki Katerina , Zapanti Evangelia , Kassis Evanthia , Alevizaki Maria

Objectives: Coexistence of two different malignancies is frequently reported. Sometimes occurs in the context of well-established syndromes like MEN2. Rearranged during transfection (RET), is an oncogenic driver activated in different kinds of neoplasias such as: MTC, Differentiated Thyroid Cancer (DTC), Non-Small Cell Lung Cancer (NSCLC). We have previously reported an increased prevalence of DTC in familial MTC patients carrying the RET (G533C) mutation. Ai...

ea0067gp3 | Poster Presentations | EYES2019

Medullary Thyroid Carcinoma (MTC); unusual metastatic sites: Two case reports

Kazakou Paraskevi , Simeakis George , Alevizaki Maria , Saltiki Katerina

Background: MTC tends to metastasize early in the course of the disease affecting usually regional lymph nodes; in 7–23% of patients distant metastases may be present at diagnosis (common metastatic sites:liver, lungs, bone). We present two MTC cases with unusual metastases to the breast, pancreas and mandible.Case presentation: Patient No 1: a 48-year-old female was diagnosed with MTC in 1990. Total thyroidectomy was performed followed by neck diss...

ea0063gp90 | Thyroid Nodules and Cancer | ECE2019

Treatment modalities in DTC patients with neck disease persistence. Second surgical intervention is more beneficial than only radioiodine (RAI) treatment

Saltiki Katerina , Simeakis George , Konstantakatou Panagiota , Sapounas Spyros , Alevizaki Maria

Objectives: DTC has a favorable clinical course. A small percentage of patients undergoing surgery and RAI ablation may have local disease persistence and further therapeutic interventions may be needed such as further RAI administration following or not a second surgery. We investigated whether additional therapeutic interventions may be beneficial for the clinical course in DTC patients with disease persistence.Methods: 812 DTC patients (men 25.7%, age...

ea0070aep956 | Thyroid | ECE2020

Medullary Thyroid Carcinoma (MTC); unusual metastatic sites. Two case reports

Kazakou Paraskevi , Simeakis George , Alevizaki Maria , Saltiki Katerina

Background: MTC tends to metastasize early in the course of the disease affecting usually regional lymph nodes; in 7–23% of patients distant metastases may be present at diagnosis (common metastatic sites:liver, lungs, bone). We present two MTC cases with unusual metastases to the breast, pancreas and mandible.Case presentation: Patient No 1A 48-year-old female was diagnosed with MTC in 1990. Total thyroidectomy was performed...

ea0049gp230 | Thyroid Cancer | ECE2017

Radioiodine (RAI) refractory differentiated thyroid cancer (DTC): outcome and prognostic factors for DISEASE progression

Saltiki Katerina , Simeakis George , Anagnostou Elli , Apostolakis Michalis , Zapanti Evangelia , Anastasiou Eleni , Alevizaki Maria

Introduction: Patients diagnosed with DTC have excellent prognosis. A small percentage of patients with disease persistence do not respond to treatment with RAI (RAI-refractory DTC) and have low median survival (3.5 years). We investigated the prognostic factors and the disease course in patients with RAI-refractory DTC.Methods: Of all DTC patients (n=1160) followed-up in our department in recent years, 800 received RAI treatment and were classified in 2...

ea0049ep1411 | Thyroid (non-cancer) | ECE2017

Clinical features of medullary thyroid carcinoma (MTC) in simultaneous occurrence with differentiated thyroid cancer (DTC)

Simeakis George , Saltiki Katerina , Anagnostou Elli , Apostolakis Michalis , Vasileiou Vasiliki , Alevizaki Maria

Objective: Simultaneous occurrence of MTC and DTC is frequently found. It is unclear whether there is a common pathogenic mechanism. Aim of our study was to characterize clinical features of MTC when coexisting with DTC.Methods: Of 273 MTC patients followed-up in our department 39 (14.3%) had MTC simultaneously with DTC. They were divided in 4 subgroups according to size. Clinical histopathological data were recorded.Results: The p...

ea0041gp237 | Thyroid Cancer (1) | ECE2016

The origin of patients with inherited medullary thyroid cancer, who are carriers of the rare exon 8 mutation (G533C) of the RET gene in Greece

Saltiki Katerina , Anagnostou Elli , Angelopoulou Anastasia , Kouki Sofia , Apostolakis Michail , Sarika Lida , Papathoma Alexandra , Alevizaki Maria

Introduction: Mutations in the ret gene are responsible for the transmission of inherited medullary thyroid cancer (MTC). In recent years a high prevalence of the ‘rare’ exon 8 mutation (G533C) has been found in patients with inherited MTC in Greece. The aim of this study was to record with more detail the place of origin of these families in the country.Design: We analysed the details of 44 patients belonging to 22 families who were c...

ea0037gp.23.08 | Thyroid – diagnosis | ECE2015

Clinical characteristics in sporadic and familial medullary thyroid carcinomas: worse outcome in sporadic cases even when disease stage at diagnosis is similar

Saltiki Katerina , Spanou Loukia , Kouki Sofia , Rentziou Gianna , Vasileiou Vasiliki , Anastasiou Eleni , Alevizaki Maria

Objectives: Medullary thyroid carcinoma (MTC) has varying clinical course with familial cases (fMTC) diagnosed earlier than sporadic ones (sMTC). We examined the presentation of these entities in our centre.Methods: 223 MTC patients (familial: 42.6%, males: 36.8%) were followed for 0.9–30 years (mean 6.23±5.9, median 4.0 years). 44 (19.7%) fMTC patients were operated after genetic screening.Results: Median age at diagnosi...

ea0037gp.27.03 | Thyroid – hyperthyroidism and treatment | ECE2015

Clinical and biochemical factors affecting prognosis of disease persistence in micro papillary thyroid carcinomas

Saltiki Katerina , Apostolakis Michael , Kouki Sophia , Spanou Loukia , Athanasiadou Anastasia , Zapanti Evangelia , Alevizaki Maria

Introduction: In recent years, micro papillary thyroid carcinomas (mPTCs; ≤1.0 cm) are increasingly diagnosed. Although clinical course is usually favourable, disease persistence may occur and multiple treatments needed. We examined factors that could be predictors of clinical behaviour and disease persistence.Patients and methods: 478 mPTC patients (78.9% females) followed-up for 0.6–10 years were classified according to tumour size in group ...