Searchable abstracts of presentations at key conferences in endocrinology

ea0022p221 | Clinical case reports and clinical practice | ECE2010

Two therapeutic approaches for thyrotropin-secreting pituitary adenomas

Sambo Marcel , Garcia Rogelio , Fernandez Elisa , Andia Victor , Lezcano Diego , Alvarez Pilar , Rodriguez Paloma

Case 1: Thirty-eight year woman consulted to gynecologist for oligomenorrhea in the last 4 years; PRL 51 μg/l and TSH 8.4 mU/l were discovered, initiating treatment with levotiroxine (f-T4). She got pregnant, persisting elevated levels of TSH and increasing f-T4, with normal campimetry. With the diagnostic of hyperthyroidism due to inadequate TSH secretion, treatment with PTU was initiated. After normal delivery, MRI showed a 22 mm. hypophisary macroadenoma and a transesp...

ea0022p328 | Diabetes | ECE2010

Follow up of type 1 diabetic patients treated with insulin continuous s.c. infusion

Andia Victor M , Fernandez Elisa , Jara Antonino , Garcia Rogelio , Sambo Marcel , Lezcano Diego A

Insulin continuous s.c. infusion (ICSI) is an alternative therapy in selected diabetic patients when a good metabolic control is not achieved with multiple insulin doses (MID). We report the follow-up of patients with ICSI at least during 1 year in our centre.Patients and methods: Twenty-five patients (16 females, 9 males), with median age 38.4±12.5 years and diabetes evolution mean time 16.8±7.8 years, were changed from MID to ICSI due to defi...

ea0020p579 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Empty sella and primary autoimmune hypothyroidism

Garcia-Centeno Rogelio , Suarez-Llanos Jose-Pablo , Fernandez-Fernandez Elisa , Andia-Melero Victor , Sambo Marcel , Sanchez Petra , Jara-Albarran Antonino

Objective: To assess the association between empty sella (ES) and primary autoimmune hypothyroidism, and the possibility of a common pathogenesis.Patients and methods: We retrospectively studied all patients with presumed ES diagnosed in the last 20 years, most of whom were treated and followed up by our Endocrinology Department. Subjects with a known aetiology were excluded. Incomplete records or those with a doubtful diagnosis were also excluded. A tot...

ea0056p138 | Endocrine tumours and neoplasia | ECE2018

Evaluation of neurofibromatosis type 1 and gastroenteropancreatic neuroendocrine tumors.

Percovich Juan Carlos , Atencia Jose , Garcia Rogelio , Sambo Marcel , Blanco Montserrat , Rotger Amanda , Lopez Dolores , Olmedilla Yoko , Picallo Maria , Velez Marian , Agreda Javier , Brox Noemi , Monereo Susana

Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant condition with an incidence of 1 in 2600 to 3000 individuals. Patients with this disorder are characterized by multiple neurofibromas, caf-au-lait macules, axillary freckling, optic gliomas, iris hamartomas, and skeletal abnormalities. Overall risk of developing neoplasms is approximately 2 to 4-fold higher in patients with NF1, with a risk of malignancy estimated between 5 and 15%. Endocrinopathies are some...

ea0081ep695 | Pituitary and Neuroendocrinology | ECE2022

Epidemiological description of 20 years of experience in the management of insulinomas in a third level hospital

Maricel Rivas Montenegro Alejandra , Ramos Roberto Jose An ez , Belinchon Sergio Santos , Gonzalez Fernandez Laura , Moreno Diego Mun oz , Fernandez Fernandez Elisa , Salas Marcel Sambo , Hualpa Juan Carlos Percovich , Gonzalez Albarran Olga , Garcia Centeno Rogelio

Introduction: Insulinoma, despite its low incidence of 0.4%, it is the most common functioning pancreatic neuroendocrine tumor. Most are benign, solitary and sporadic. Around 10% can be malignant and 5-10% are part of MEN-1. On certain occasions, the differential diagnosis is difficult when there is a history of Diabetes Mellitus (DM). Our objective was to describe clinical-epidemiological data and its diagnostic-therapeutic management.Materials and Meth...

ea0049ep1030 | Pituitary - Clinical | ECE2017

Hormone and tumor responses to primary or pre-operative therapy with somatostatin analogs in acromegaly and the relation with T2-weighted MRI signal

Picallo Maria , Centeno Rogelio Garcia , Guerra Aurelio Lopez , Olmedilla Yoko Lucia , Arnoriaga Maria , Requena Maria , Agreda Javier , Andia Victor , Sambo Marcel , Monereo Susana , Velez Maria Angeles , Weber Bettina , Atencia Jose

Objective: Study of the efficacy of SSA in the biochemical and tumour control and the relation between the T2-weighted MRI signal intensity and the response to SSA.Material and methods: 16 patients with GH-secreting pituitary adenomas (7♂/9♀) that received primary or pre-operative treatment with SSA. We classified them according to baseline T2-weighted MRI sequences as Hypo-intense (Ha) and No-Hypo-intense adenomas (no-Ha). Results expressed ...

ea0035p237 | Clinical case reports Pituitary/Adrenal | ECE2014

Hyperprolactinemia secondary to primary hypothyroidism with hyperplasia pituitary

Centeno Rogelio Garcia , Melero Victor Andia , Fernandez Elisa Fernandez , Salas Marcel Sambo , Gonzalez-Antiguedad Cynthia , de la Camara Marta Motilla , Solis Diego Lezcano , Gonzalez Javier , Rivadeneira Lenin , Requena Maria , Ramirez Maria Laura , Olmedilla Yoko , Arnoriaga Maria

Introduction: Although the most common causes of hyperprolactinemia are prolactinoma and iatrogenic, another possible cause is severe primary hypothyroidism, in which the increase of prolactin is a cause of pituitary stimulation by TRH, and can be presented with pituitary hyperplasia.Case report: A 31-year-old woman who comes to endocrinology clinic for hyperprolactinemia, which was detected by symptoms of amenorrhea–galactorrhea. After normal pregn...

ea0035p445 | Diabetes complications | ECE2014

Autoimmune pancreatitis after intravenous insulin desensitization in a diabetic patient allergic to insulin without pancreatic reserve

Salas Marcel Sambo , Melero Victor Andia , Ishishi Yoko Olmedilla , Centeno Rogelio Garcia , Ramirez Maria Laura , Motilla Marta , Antiguedad Cynthia Gonzalez , Requena Maria , Lopez Javier Gonzalez , Rivadeneira Lenin , Arnoriaga Maria

Introduction: Allergy is an uncommon side-effect of insulin treatment in which desensitization represents an alternative when initial approaches are not effective. Autoimmune pancreatitis (AIP) is an even more rare disease that generally has a successful response to corticosteroids. The case of a 50-year-old diabetic man who developed both processes sequentially is presented.Case report: The patient was admitted for acute diabetes mellitus (DM) decompens...

ea0070aep953 | Thyroid | ECE2020

Diagnostic patterns of relapsed differentiated thyroid cancer (DTC) and the efficacy of rescue therapies (ERUDIT Study)

Sambo Marcel , Navarro Elena , Aller Javier , Guadalix Sonsoles , Zafón Carlos , González Cristina , Santamaría Javier , González Marcelino , Puig Manel , Galofré Juan C. , Argüelles Iñaki , Vallejo Juan A. , Pubul Virginia , Santos Rita , Llanos Marta , Crespo Guillermo , Segura Ángel , Navarro Miguel , Gajate Pablo , Valdivia Javier , López Carlos , Castelo Beatriz , Villanueva María J. , Araujo Fábia , Orcajo Lorenzo , Rodríguez-Villanueva Julio

Introduction: Advanced differentiated thyroid carcinoma (aDTC) – herein defined as locally unresectable or metastatic disease – is one of the most common late-stage endocrine neoplasias. However, available data about its natural history is limited. ERUDIT is a multicenter, observational, retrospective study of patients diagnosed with aDTC in Spain and Portugal. The study describes its natural history from the initial diagnosis until the advanced stages of disease, ...

ea0073aep871 | Late Breaking | ECE2021

Relapsed Differentiated Thyroid Cancer, clinical presentation, treatment, and prognostic factors (ERUDIT Study)

Sambo Marcel , Elena Navarro González , Aller Pardo Javier , Guadalix Iglesias Sonsoles , Carles Zafón Llopis , Cintia González Blanco , Javier Santamaría Sandi , Marcelino Gómez Balaguer , Puig Domingo Manel , Juan C. Galofré Ferrater , Iñaki Argüelles Jiménez , Santos Rita , Marta Llanos Muñoz , Juan Antonio Vallejo Casas , Virginia Pubul Núñez , Crespo Herrero Guillermo , Ángel Segura Huerta , Miguel Navarro Martín , Gajate Borau Pablo , Valdivia Bautista Javier , Beatriz Castelo Fernández , Carlos López López , María J. Villanueva Silva , Orcajo Lorenzo , Julio Rodríguez-Villanueva García

Advanced differentiated thyroid carcinoma (aDTC), herein defined as locally unresectable and/or metastatic, is one of the most common late-stage endocrine neoplasias. However, available data about its natural history are limited. ERUDIT is a multicenter, observational, retrospective study of patients diagnosed with aDTC in Spain and Portugal. The study describes its natural history from the initial diagnosis until the advanced stages, focusing on specific characteristics of th...