Searchable abstracts of presentations at key conferences in endocrinology

ea0063p87 | Calcium and Bone 1 | ECE2019

Heterogenous clinical presentation of primary hyperparathyroidism in Romania

Grigorie Daniel , Sucaliuc Alina

Introduction: In the last decades, primary hyperparathyroidism (PHPT) has changed in its clinical presentation, being mostly asymptomatic in western countries; in Romania is still common to see various clinical presentations.Objective: To characterize a retrospective cohort of PHPT Romanian patients.Patients and methods: 271 patients were included: 88% women, ratio F/M 7.5/1, mean age 60.6±12 yrs (15–83), mean BMI 26.3&#1...

ea0081ep181 | Calcium and Bone | ECE2022

Small and foudroyant parathyroid carcinoma with lung metastasis and no local invasion at diagnosis

Grigorie Daniel , Ghemigian Mircea , Ioachim Dumitru , Florescu Cristina , Sucaliuc Alina

Parathyroid carcinoma (PC) rarely presents with metastasis at diagnosis and usually in patients also having gross local invasion.Case presentation: We report the case of a 51-year-old postmenopausal woman presenting at our institution in June 2019 with symptomatic hypercalcemia (fatigue, polyuria, constipation and bone pain), but with a surprisingly good general condition. She had been treated with bisphosphonates for osteoporosis (DXA: LS T score &#8722...

ea0049ep240 | Bone & Osteoporosis | ECE2017

Trabecular bone score is negatively associated with bone resorbtion markers in patients with primary hyperparathyroidism

Grigorie Daniel , Ivan Mirela , Caragheorgheopol Andra , Paun Diana , Sucaliuc Alina

Objectives: Mean TBS (Trabecular Bone Score) values are generally lower in PHPT (primary hyperparathyroidism) patients than controls. The aim of this study was to assess TBS from spine DXA images in patients with PHPT and look at its correlates.Methods: This was a cross-sectional study conducted in an osteoporosis referral center. One hundred and thirty six patients with PHPT were selected from our database (2010–2016) if they had a valid LS DXA sca...

ea0037ep259 | Calcium and Vitamin D metabolism | ECE2015

Rapid and profound decrease in resorbtion markers preceded early and profound increase in BMD after successful surgery in osteitis fibrosa cystica

Grigorie Daniel , Caragheorgheopol Andra , Iacob Maria , Sucaliuc Alina

Introduction: Successful parathyroid surgery in patients with OFC leads to early and marked improvements in BMD but data on very early changes in bone markers are missing.Case report: A 20-year-old girl was hospitalised because of severe bone pains and multiple pathological fractures (left humerus and left proximal femur) after minimal trauma. She had lost weight, was amenorrhoeic for the last 12 months and was bleeding from brown tumours in her mouth. S...

ea0037ep1213 | Clinical Cases–Pituitary/Adrenal | ECE2015

5 years complete clinical remission after single adrenalectomy for severe occult ACTH-dependent Cushing's syndrome

Grigorie Daniel , Caragheorgheopol Andra , Hortopan Dan , Sucaliuc Alina

Introduction: Complete long-term clinical remission in occult ectopic ACTH syndrome after a single adrenalectomy is unexpected.Case report: 5 year ago, a 54-year-old man was admitted because of resistant HTA, multiple severe vertebral fractures, muscle weakness and cushingoid features of at least 1 year. Adrenal tests were diagnostic of ACTH-dependent Cushing’syndrome: ACTH=263 pg/ml, high plasma (62 μg/dl) and urinary free cortisol (UFC=1256 &...

ea0022p91 | Bone/Calcium | ECE2010

Long-term follow-up of the changes in serum 25-hydroxivitamin D to oral treatment with vitamin D3 in patients with postmenopausal osteoporosis

Grigorie Daniel , Sucaliuc Alina , Ivan Mirela , Neacsu Elena , Diaconescu Alina

The oral dosing with cholecalciferol needed to achieve and maintain optimal serum concentration 25-hydroxyvitamin D (25OHD) is still controversial.This study reports on the efficacy of supplementation with oral vitamin D3 1000 U/day for 3–18 months on serum 25OHD levels in 87 ambulatory patients with postmenopausal osteoporosis (mean age 63.5 years). Serum 25OHD, parathyroid hormone (PTH), calcium (serum, urine), phosphate, alkaline phosphatase and ...

ea0073aep134 | Calcium and Bone | ECE2021

FGF23 secreting mesenchymal tumor of the foot: Localizing pitfalls

Sucaliuc Alina , Diana Anghel , Cristescu Ioan , Grigorie Daniel

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of chronic hypophosphatemia caused by the production of FGF23 in a typically small, benign, mesenchymal tumor. The diagnosis is often delayed and finding the tumor is sometimes challenging. We present a case of a 50 yrs old woman with TIO, referred to our clinic for progressive muscle weakness, diffuse bone pain and fractures, extensively investigated for 3 years. 2 years before admission she had a vertebroplas...

ea0073aep757 | Thyroid | ECE2021

Fetal and neonatal thyrotoxicosis after 12 years from thyroid surgical ablation for Graves disease

Bohaltea Roxana , Sucaliuc Alina , Szini Elena , Grigoriu Corina , Badiu Corin

Clinical fetal thyrotoxicosis is a rare disease occurring in 1-5% of pregnancies with Graves disease. Although transplacental passage of maternal TSH receptor stimulating autoantibodies (TRab) to the fetus does occur early in gestation, the fetal concentration is low until the end of second trimester, but reaches maternal levels in the last period of pregnancy. The mortality of fetal thyrotoxicosis is 12–20% mainly due to heart failure. We present a case of fetal and neo...

ea0090p321 | Calcium and Bone | ECE2023

Severe persistent hypocalcemia and hungry bone syndrome after parathyroidectomy in a patient with giant parathyroid adenoma and concurrent osteoblastic bone metastasis from prostate cancer

Nicoleta Dumitru Alida , Sucaliuc Alina , Alexandrescu Octavian , Pena Catalina , Grigorie Daniel

Introduction: Hungry bone syndrome (HBS) is a rare condition that can appear after surgery for hyperparathyroidism, characterized by hypocalcemia, hypophosphatemia, low calciuria, especially in patients with severe primary hyperparathyroidism, bone lesions and elevated alkaline phosphatase. We present a case of severe persistent hypocalcemia after resection of a giant parathyroid adenoma in a patient with concurrent osteoblastic bone metastasis from prostate cancer.<p clas...

ea0090ep590 | Endocrine-related Cancer | ECE2023

Incidental diagnosis of MEN2a in a patient with concurrent ovarian carcinoma presenting with cervical lymphadenopathies

Pena Catalina , Sucaliuc Alina , Mircea Ghemigian , Iulian Brezean , Nicoleta Dumitru Alida , Daniel Grigorie

Introduction: Multiple endocrine neoplasia type 2A is an autosomal dominant disorder which is characterized by the occurrence of medullary thyroid carcinoma in association with pheochromocytoma and parathyroid tumors.Case report: We present the case of a 64-year-old woman, with familial history of thyroid carcinoma, renal lithiasis and personal history of right nephrectomy for renal lithiasis, who presented for the investigation of a left lateral cervica...