Endocrine Abstracts

Thyrotoxic periodic paralysis (TPP) is uncommon complication of Graves’ disease mainly observed in young males of Asian origin. It is rarely seen among white hyperthyroid patients (0.1–0.2%), usually presented as lower extremities muscle weakness of sudden onset, probably cause by hypokalemia. Possible mechanism of hypokalemia is an increased sodium–potassium–adenosine triphosphatase pump activity with consequent massive shift og potassium from extracellula...

Aim/hypothesis: Chronic renal failure maintenance hemodialysis (HD) patients are at risk for low bone mineral density (BMD) and fractures. Parathyroid hormone (iPTH) plays a pivotal role in the pathophysiology of uremic bone disease, but in healthy population body weight and particularly body composition are more important determinants of bone mass.Patients and methods: We studied BMD (results were recorded as g/cm2) and T score using D...

Background/Aims: High level of inflammatory cytokines was present within malnourished and chronic renal failure maintenance hemodialysis (MHD) patients, but there were conflicting data about the role of inflammation on development of insulin resistance (IR) in non-obese and overweight MHD patients.Methods: We selected 23 well-nourished and 20 middle- to moderate-malnourished, sex and age-matched, stable MHD patients, 23 male and 20 female, with median di...

Background: We know that lipid profile is disturbed in both subclinical hypothyroidism (SH) and metabolic syndrome (MetSy). In this study we observed lipid profile in newly diagnosed patients with SH and MetSy.Materials and methods: We chose 70 patients (all females) with newly discovered SH and 20 healthy controls, mean age 51.1 (±6.79). The parameters that we determined are: TSH, FT4, anti-TPO-At, triglycerides, whole, LDL and HDL chole...

Introduction: Ectopic thyroid tissue is a rare developmental abnormality with the prevalence of 1 per 100.000–300.000 persons in the general population. It is most commonly detected in younger women and presented as lingual thyroid. Here we report a rare case of ectopic thyroid tissue in the left adrenal gland.Case report: A 29-year old female without previous medical history was incidentally diagnosed with left adrenal gland mass detected on routi...

Background: Recently many authors are questioning the existing of elements of metabolic syndrome (MetSy) in patients with subclinical hypothyroidism (SH). In this cross sectional study we observed glycemia, as an element of MetSy, in newly diagnosed patients with SH.Materials and methods: Seventy females participated in study. Among them there were 50 patients with SH, mean age 58.3 (±8.53), and 20 controls without SH, mean age 51.1 (±6.79). We...

Introduction: By using insulin analogue, it is expected to improve glycemic regulation in poorly controlled type 2 diabetes (t2DM). The aim of the study was to examine the quality of glycemic control and quality of life (QoL) of patients managed with insulin analogues, previously treated with human insulin.Materials and methods: The pilot study included 30 t2DM outpatients, divided into two groups (15 subjects) – the first group was treated with hum...

Background and aim: Iron overload and inflammation might participate in the pathogenesis of insulin resistance in community. The improvement of insulin resistance in hemodialysis (HD) patients is frequently seen after correction of anemia. The aim of this study was to investigate the influence of recobinant humam erythropoietin (Epo) treatment on insulin resistance in non-diabetic HD patients.Patients and methods: We investigated the effects of 6 months-...

Introduction: Subclinical and clinical primary hypothyroidism potentially makes a negative influence on the patient’s quality of life. Present study examined the level of hypothyroid symptoms and signs expression as well patient’s quality of life before levothyroxine and after substitutionally-induced laboratory euthyroidism.Material and methods: Prospective case–control study consisted of 75 female patients divided into three groups based...

Objective: Hyperthyroidism is accompanied by low bone mass. Because the reference range of TSH levels is defined statistically, some individuals with high-normal TSH levels (TSH <10 mU/l), may have mild hypothyroidism (subclinical hypothyroidism) and reduced bone mass. We therefore determined whether serum TSH levels correlate with bone mineral density (BMD) in persons with subclinical hypothyroidism.Design: A cross-sectional study.<p class="abst...