Searchable abstracts of presentations at key conferences in endocrinology

ea0067o2 | Oral Presentations | EYES2019

Occurrence of second primary malignancy in medullary thyroid cancer (MTC) patients

Simeakis George , Saltiki Katerina , Zapanti Evangelia , Kassis Evanthia , Alevizaki Maria

Objectives: Coexistence of two different malignancies is frequently reported. Sometimes occurs in the context of well-established syndromes like MEN2. Rearranged during transfection (RET), is an oncogenic driver activated in different kinds of neoplasias such as: MTC, Differentiated Thyroid Cancer (DTC), Non-Small Cell Lung Cancer (NSCLC). We have previously reported an increased prevalence of DTC in familial MTC patients carrying the RET (G533C) mutation. Ai...

ea0032p1038 | Thyroid (non-cancer) | ECE2013

Relationship of benign thyroid disorders with histological alterations of breast tissue. (Preliminary results of an observational study conducted in Greece)

Angelousi Anna , Zapanti Evangelia , Prokopiou Maria , Kouraklis Grigorios , Kontzoglou Konstantinos

Introduction: The association of thyroid disorders including autoimmune thyroiditis with the risk for breast cancer is controversial (1–4). A recent study found that triidothyronine (T3) levels are positively associated with breast cancer specific mortality (5). Experimental studies have shown that T3 mimics the effects of estrogen in human breast cell lines and induces the expression of progesterone receptors (6).Purpose: The ...

ea0049gp80 | Diabetes & complications 1 | ECE2017

Trace elements as an oxidative stress marker in women with gestational diabetes and their neonates

Boutzios Georgios , Koukoulioti Eleni , Papoutsis Ioannis , Athanaselis Sotirios , Tsourouflis Gerasimos , Zapanti Evangelia

Background and aims: Gestational diabetes (GD) is closely related to unbalanced zinc (Zn) and cooper (Cu) serum levels. The aim of this study was to investigate serum zinc and cooper levels in relation to the metabolic profile, and the impact on fetal development in a cohort of gestational diabetes GD(N) neonates and their mothers GD(M) compared to normal pregnancies.Material and Methods: Prospective controlled study in a tertiary Academic medical center...

ea0049gp230 | Thyroid Cancer | ECE2017

Radioiodine (RAI) refractory differentiated thyroid cancer (DTC): outcome and prognostic factors for DISEASE progression

Saltiki Katerina , Simeakis George , Anagnostou Elli , Apostolakis Michalis , Zapanti Evangelia , Anastasiou Eleni , Alevizaki Maria

Introduction: Patients diagnosed with DTC have excellent prognosis. A small percentage of patients with disease persistence do not respond to treatment with RAI (RAI-refractory DTC) and have low median survival (3.5 years). We investigated the prognostic factors and the disease course in patients with RAI-refractory DTC.Methods: Of all DTC patients (n=1160) followed-up in our department in recent years, 800 received RAI treatment and were classified in 2...

ea0037gp.27.03 | Thyroid – hyperthyroidism and treatment | ECE2015

Clinical and biochemical factors affecting prognosis of disease persistence in micro papillary thyroid carcinomas

Saltiki Katerina , Apostolakis Michael , Kouki Sophia , Spanou Loukia , Athanasiadou Anastasia , Zapanti Evangelia , Alevizaki Maria

Introduction: In recent years, micro papillary thyroid carcinomas (mPTCs; ≤1.0 cm) are increasingly diagnosed. Although clinical course is usually favourable, disease persistence may occur and multiple treatments needed. We examined factors that could be predictors of clinical behaviour and disease persistence.Patients and methods: 478 mPTC patients (78.9% females) followed-up for 0.6–10 years were classified according to tumour size in group ...

ea0022p315 | Diabetes | ECE2010

Vitamin D deficiency and isolated fasting hyperglycemia in pregnancy

Vasileiou Vasiliki , Athanasiadou Anastasia , Giakoumi Athanasia , Papageorgiou George , Zapanti Evangelia , Alevizaki Maria , Anastasiou Eleni

Introduction: The relation between vitamin D deficiency and gestational diabetes mellitus (GDM) has been rarely addressed in the literature with conflicting results. The aim is to determine the association between maternal serum 25(OH)D and glucose metabolism in Caucasian pregnant women.Patients and methods: In a prospective study 157 pregnant women aged 31.2±5.8 years underwent a 100 g OGTT in the third trimester of pregnancy, during which serum 25...

ea0020p304 | Clinical case reports and clinical reports | ECE2009

Double primary ovarian malignancies in a patient with bipolar disease complicating Swyer syndrome

Zapanti Evangelia , Giakioumi Athanasia , Terzidis Konstantinos , Thomakos Nikolaos , Rodolakis Alexandros , Grigori P , Alevizaki Maria

Background: Swyer syndrome is a type of pure gonadal dysgenesis 46 XY caryotype in phenotypically female patients. A rare case of Swyer syndrome complicated by dysgerminoma and Retiform Sertoli-Leydig cell’s tumor is reported.Case presentation: A 20-year-old phenotypically female patient presented to our department with primary amenorrhea. She was 1.68 m and weighed 82 kg (BMI 28). She presented with minimal breast development, sparse axillary and p...

ea0056gp264 | Thyroid non cancer - Autoimmune Thyroid disease/pregnancy | ECE2018

Thyroid function in pregnant women; relation to Gestational Diabetes Mellitus (GDM) and Body Mass Index (BMI)

Simeakis George , Vogiatzi Evangelia , Konstantakou Panagiota , Zapanti Evangelia , Saltiki Katerina , Alevizaki Maria , Anastasiou Eleni

Objectives: The interplay between thyroid function and metabolic state has been studied in many population subgroups. For pregnant women thyroid and metabolic parameters, including glucose homeostasis, are of great importance for a successful outcome. We examined aspects of thyroid function in relation to GDM and BMI in pregnant women referred to our Department.Methods: We studied 520 women during 24th – 32nd gestation week. De...

ea0056p1097 | Thyroid (non-cancer) | ECE2018

Primary thyroidal paraganglioma in a 60 years old female with thyroid goiter

Sapounas Spyridon , Manthakos Christos , Pissia Maria , Saltiki Katerina , Anastasiou Eleni , Zapanti Evangelia

Primary Paraganglioma of Thyroid Gland is an extremely rare neuroendocrine tumor. Less than 50 cases have been reported up to date and its rarity is the reason why it’s often mistaken for thyroid nodule or other thyroid neoplasms. In this case we describe the misleading results of ultrasonography followed by FNA-biopsy, which led to a total delay of two years until final diagnosis. A 60 year old female presented with a 38 mm right-sided thyroid module. An ultrasound guide...

ea0056p1143 | Thyroid cancer | ECE2018

The significance of postoperative calcitonin (CT) levels in the evaluation of disease course in medullary thyroid cancer (MTC) patients

Saltiki Katerina , Simeakis George , Vogiatzi Evangelia , Kassi Eva , Zapanti Evangelia , Alevizaki Maria

Aim: Postoperative calcitonin (postCT) is a prognostic factor for disease progression in MTC patients. We evaluated the disease course in patients with persistently elevated post-CT.Methods: Of all MTC patients (n=273) followed-up in our Unit (for 1–37, median 7 years), 140 (39.3% men, 67.1% sporadicMTCs) had persistently elevated postCT (≥2.0 pg/ml). Clinical and biochemical data were recorded. Patients were classified in four groups...