Endocrine Abstracts

Introduction: Fasting during Ramadan is an obligatory practice for adultMuslims. Although exemptions exist in certain conditions, including diabetes, the majority ofdiabetic patients fast despite this concession with the risk of complications mainly hypoglycemic accidents.The aim of this study is to establish the relationship between hypoglycemic accidents and drug treatment, therapeutic education, clinical and biological characteristics oftunisian diabe...

Introduction: The glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency in humans. In red blood cells, the pentose phosphate pathway is the only source of nicotinamide adenine dinucleotide (NADPH), and defense mechanisms against oxidative damage are highly dependent on G6PD activity. The occurrence of acute haemolysis in patient with G6PD deficiency and diabetes has been reported and ascribed to various mechanisms. Her we report a case of pat...

Introduction: Insulin therapy ( IT) in type 2 diabetes( T2D) is an integral Pharmacologic Approache because of the progressive nature of the disease. Insulin improves glycemic control and reduces the risk of microvascular complications. It’s however associated with weight gain as a side effect which promotes insulinoresistance and cardiovascular morbi–mortality.In this work we evaluated long–term weight gain in insulin–treated pat...

Introduction: Diabetes is the leading cause of end-stage renal disease in Europe (12 to 30%). In the United States, it is the cause of more than half of the cases of this disease. Renal disease is a cardiovascular morbidity and mortality preacher which is three times more common in diabetic patients with diabetic nephropathy (DN). The aim of our study was to describe the factors of cardiovascular risk associated with ND in a group of type 2 diabetes (T2D) Tunisians.<p clas...

Background: Aging patients with type 2 diabetes mellitus have a higher risk of developing hypoglycemia. Many studies show the effect of beta-blockers in hiding hypoglycemia symptoms and therefore the occurrence of a severe hypoglycemia. These agents are commonly used in diabetic patients with coronary heart disease. The aim of this study was to assess whether the use of beta-blockersdeteriorates the glycemic control.Methods: We conducted a retrospective ...

Background: The management of diabetic foot starts with prevention, mainly based on the early detection of peripheral neuropathy and peripheral arterial disease, called podiatric risk assessment. This risk must be evaluated in all type 2 diabetics since the discovery. The aim of this study was the assessment of diabetic foot ulcer risk according to International Working Group on the Diabetic Foot (IWGDF) and the identification of risk factors for developing foot lesions.<p...

Background: The management of gestational diabetes mellitus (GDM) is based on nutrition therapy associated to insulin therapy in second intention if glycemic targets are not achieved. The aim of this study was to assess predictive factors of insulin requirement in a group of pregnant women with GDM.Methods: We conducted a retrospective study at the Outpatient Department and functional explorations, in the National Institute of Nutrition of Tunis, between...

Introduction: Obesity is a major health problem through its numerous complications especially metabolic complications associated with cardiovascular risk. The aim of our work was to describe the clinico-metabolic profile of obese Tunisian adults.Methods: This was a descriptive cross-sectional study involved 174 obese patients who consulted between July and December 2020 at the Obesity Unit of the National Institute of Nutrition in Tunis. ResultsThe avera...

Introduction: Insulin therapy remains a treatment of last resort for type 2 diabetic patients with uncontrolled diabetes with oral antidiabetic. The aim of this study was to find a correlation between the initial dose of insulin and the glycated hemoglobin (A1c) level.Methods: We conducted a cross sectional study. We included 63 patients with type 2 diabetes hospitalized for a switching to insulin in the C department of diabetology and nutrition at the N...

Introduction: Obesity is the disease of modern society whose prevalence continues to increase.The aim of this study was to compare the cardio-metabolic profile of morbid obesity with that of moderate to severe obesity.Methods: It was a retrospective study conducted at the obesity unit of the national institute of nutrition in Tunis including 174 obese patients We divided the population into two groups. Group 1 (G1) with morbid obes...