Endocrine Abstracts

Background: British Association of Thyroid and Endocrine Surgeons defines post-operative hypocalcaemia as adjusted calcium of < 2.0 mmol/l; ‘late hypocalcaemia’ as the ongoing requirement for calcium/Vitamin D supplements at 6 months; permanent post-surgical hypoparathyroidism (PSHP) at 12 months. The incidence rates of late hypocalcaemia are 6.5–12.1% and PSHP is 0.9%–4.5%.Objective: To evaluate PSHP incidence rate in total thyro...

Introduction: Eating habits may contribute to longevity. Consumption of red meat, source of saturated fatty acids and cholesterol may be associated with increased risks of diabetes, cardiovascular disease (CVD), and mortality risk.Methods: We studied 521 subjects, both genders, 253 centenarians (CENT) (100.26±1.98 age) and 268 controls (67.51±3.25 age), both low (LCR) and high cardiovascular risk (HCR), calculated based on QRISK®2-2016. An...

Introduction: Differentiated thyroid cancer (DTC) is one of the most frequent forms of malignancy. Because of its favourable outcome and low mortality rates, identifying prognostic factors has been a challenge. Several risk stratification systems have been developed. Most of them include demographic and tumour specific features, as well as extrathyroidal extension. Our objective was to compare clinical characteristics between DTC patients with and without remission.<p clas...

Insulin autoimmune syndrome (IAS) is a very rare cause of hypoglycaemia in western countries. One proposed mechanism is anti-insulin antibody capture of prandial insulin followed by the dissociation of insulin from anti-insulin antibody. The first objective was to study the relationship between glucose, insulin and C-peptide during a prolonged glucose load in two patients with active IAS. The second was to study the variation of these parameters between the active and the reco...

Introduction: Bariatric surgery (BS) candidates display several nutritional deficiencies that can aggravate after surgery. Metabolic syndrome (MS) is a cluster of cardiovascular risk factors with several disturbed metabolic pathways. Therefore, individuals with MS submitted to BS are probably more prone to nutritional deficiencies.Objective: To evaluate the prevalence of nutritional deficiencies and eventual differences between BS candidates with and wit...

Background: Sleeve gastrectomy (SG) has effective results on weight loss, which should result from fat mass loss and efforts should be made to preserve lean mass. Few studies have evaluated body composition (BC) changes after SG for periods >2 years.Objective: To investigate the impact of SG on weight and BC, comparing by gender.Materials and methods: Retrospectively, databases of patients who underwent SG between 2011 and 2013...

Introduction: Fat-free mass has a functional significance in aging. The objective of this study was to evaluate the prevalence of underweight in a Portuguese population of centenarians and their relationship with dehydration or sarcopenia.Methods/design: Anthropometric data were obtained using standard procedures from 252 centenarians (100.26±1.99 years), 77.8% women (W). Body composition was assessed by tetrapolar bioimpedance. It was considered de...

Paediatric Graves’ disease (PGD) is an uncommon autoimmune disorder with a multifactorial origin. Although, in some autoimmune endocrinophaties the seasonality of month of birth (MOB) distribution differed from the general population, this association has not been study in PGD. The aim of this work was to analyse the impact of seasonality of MOB on PGD incidence in Portugal.In 2013, the Portuguese Paediatric Society of Diabetes and Endocrinology und...

Spindle cell oncocytoma (SCO) is a rare entity with just 18 cases reported in the literature. It was first described in 2002 and was codified as a separate diagnostic entity in the 2007 WHO classification of brain tumours. SCO is a nonadenomatous sellar neoplasm with rich vascularization and intra and supra-sellar infiltration. Usual clinical presentation consists of headache, visual field defects and pan-hypopituitarism. The preoperative diagnosis is difficult due to a lack o...

Introduction: Adult growth hormone deficiency (AGHD) is associated with lower bone mass and likely with increased risk of fragility fractures. GH replacement leads to increase in bone mineral density (BMD) and trabecular bone score (TBS). The effect of adequate levels of vitamin D during GH replacement is important to provide effect on TBS.Aim: To assess long–term effectof recombinant GH replacement on BMD and TBS with regards to vitamin D levels d...